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BR2_PELPV
ID   BR2_PELPV               Reviewed;          33 AA.
AC   P32424;
DT   01-OCT-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1993, sequence version 1.
DT   25-MAY-2022, entry version 61.
DE   RecName: Full=Brevinin-2;
OS   Pelophylax porosus brevipodus (Nagoya Daruma pond frog) (Rana brevipoda
OS   porosa).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Neobatrachia; Ranoidea; Ranidae; Pelophylax.
OX   NCBI_TaxID=88447;
RN   [1]
RP   PROTEIN SEQUENCE, AND DISULFIDE BOND.
RC   TISSUE=Skin secretion;
RX   PubMed=1449472; DOI=10.1016/0006-291x(92)91542-x;
RA   Morikawa N., Hagiwara K., Nakajima T.;
RT   "Brevinin-1 and -2, unique antimicrobial peptides from the skin of the
RT   frog, Rana brevipoda porsa.";
RL   Biochem. Biophys. Res. Commun. 189:184-190(1992).
CC   -!- FUNCTION: Shows antibacterial activity against representative Gram-
CC       negative and Gram-positive bacterial species, and a very high hemolytic
CC       activity.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed by the skin glands.
CC   -!- SIMILARITY: Belongs to the frog skin active peptide (FSAP) family.
CC       Brevinin subfamily. {ECO:0000305}.
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DR   PIR; JC1356; JC1356.
DR   AlphaFoldDB; P32424; -.
DR   SMR; P32424; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   GO; GO:0044179; P:hemolysis in another organism; IEA:UniProtKB-KW.
DR   InterPro; IPR012521; Antimicrobial_frog_2.
DR   Pfam; PF08023; Antimicrobial_2; 1.
PE   1: Evidence at protein level;
KW   Amphibian defense peptide; Antibiotic; Antimicrobial; Cytolysis;
KW   Direct protein sequencing; Disulfide bond; Hemolysis; Secreted.
FT   PEPTIDE         1..33
FT                   /note="Brevinin-2"
FT                   /id="PRO_0000044646"
FT   DISULFID        27..33
FT                   /evidence="ECO:0000269|PubMed:1449472"
SQ   SEQUENCE   33 AA;  3254 MW;  BCD5D32E27DBCB96 CRC64;
     GLLDSLKGFA ATAGKGVLQS LLSTASCKLA KTC
 
 
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