ID   TECT2_RAT               Reviewed;         700 AA.
AC   Q3B7D3;
DT   04-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT   22-NOV-2005, sequence version 1.
DT   03-AUG-2022, entry version 88.
DE   RecName: Full=Tectonic-2;
DE   Flags: Precursor;
GN   Name=Tctn2; Synonyms=Tect2;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Prostate;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Component of the tectonic-like complex, a complex localized
CC       at the transition zone of primary cilia and acting as a barrier that
CC       prevents diffusion of transmembrane proteins between the cilia and
CC       plasma membranes. Required for hedgehog signaling transduction (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Part of the tectonic-like complex (also named B9 complex).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC       membrane protein {ECO:0000305}. Cytoplasm, cytoskeleton, cilium basal
CC       body {ECO:0000250}. Note=Localizes at the transition zone, a region
CC       between the basal body and the ciliary axoneme. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the tectonic family. {ECO:0000305}.
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DR   EMBL; BC107658; AAI07659.1; -; mRNA.
DR   RefSeq; NP_001074251.1; NM_001080782.1.
DR   AlphaFoldDB; Q3B7D3; -.
DR   STRING; 10116.ENSRNOP00000001349; -.
DR   GlyGen; Q3B7D3; 5 sites.
DR   PhosphoSitePlus; Q3B7D3; -.
DR   PRIDE; Q3B7D3; -.
DR   Ensembl; ENSRNOT00000084553; ENSRNOP00000072568; ENSRNOG00000052704.
DR   GeneID; 689779; -.
DR   KEGG; rno:689779; -.
DR   UCSC; RGD:1591895; rat.
DR   CTD; 79867; -.
DR   RGD; 1591895; Tctn2.
DR   eggNOG; KOG2189; Eukaryota.
DR   GeneTree; ENSGT00940000154642; -.
DR   HOGENOM; CLU_025134_0_0_1; -.
DR   InParanoid; Q3B7D3; -.
DR   OrthoDB; 446525at2759; -.
DR   Reactome; R-RNO-5620912; Anchoring of the basal body to the plasma membrane.
DR   PRO; PR:Q3B7D3; -.
DR   Proteomes; UP000002494; Chromosome 12.
DR   Bgee; ENSRNOG00000052704; Expressed in jejunum and 19 other tissues.
DR   ExpressionAtlas; Q3B7D3; baseline and differential.
DR   Genevisible; Q3B7D3; RN.
DR   GO; GO:0035869; C:ciliary transition zone; ISO:RGD.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-KW.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0036038; C:MKS complex; ISS:UniProtKB.
DR   GO; GO:0060271; P:cilium assembly; ISS:UniProtKB.
DR   GO; GO:1904491; P:protein localization to ciliary transition zone; ISO:RGD.
DR   GO; GO:0007224; P:smoothened signaling pathway; ISS:UniProtKB.
DR   InterPro; IPR040354; Tectonic.
DR   InterPro; IPR011677; Tectonic_dom.
DR   PANTHER; PTHR14611; PTHR14611; 1.
DR   Pfam; PF07773; DUF1619; 1.
PE   2: Evidence at transcript level;
KW   Cell projection; Cilium biogenesis/degradation; Cytoplasm; Cytoskeleton;
KW   Glycoprotein; Membrane; Reference proteome; Signal; Transmembrane;
KW   Transmembrane helix.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000255"
FT   CHAIN           26..700
FT                   /note="Tectonic-2"
FT                   /id="PRO_0000229800"
FT   TOPO_DOM        26..665
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        666..682
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        683..700
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        76
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        82
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        146
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        156
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        389
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   700 AA;  77301 MW;  D11C5B9C3CC4EE1D CRC64;
     MGSLSPLSFL WGLLLLQGVL RPLRGDPVFI PPFIRMSSPE VRASLVGGSE DVTVSLTPLQ
     IKEGVLPVPT CGGLRNETGD WNLTVSPQAN MLEVTVRWKR GLDWCSPDET ASFSEAPCIV
     QTLLVSASHN ASCLAHLLIQ VEIYPNTSVT HNASENMTVI PNQVYQPLGP CPCDLTAKAC
     DIRCCCDQDC QPELRELFER FCFSGVFGGY VSPPSHHRCA ARTTHQTPDW FPFLCVQSPP
     STSPFLGHFY HGAISPRHSP GFETHSHLDL RDFFADASYK QGDPIMTTNG YFTIPQASLA
     GQCLQDAPVA FLRNFHSVCT TDLEVQERDR LIPEDMRIRT TGGLVTPTVT YEEATDLDKL
     ITSPDTILSA GSAPRNVTVE EHYVFRWQNN SISSLDITII RAEINAHQRG TMTQRFTVKF
     LSPNSGGEKE FSGNPGYQLG KPVRALHTDG MNVTTLHLWQ PAGRGLCTSA ALRPVLFGED
     ASSGCLLEVG IKENCTQLRE NVLQRLDLLI QATHVARRGN SDYGDLSDGW LEVIRVDAPD
     AGADLPLSSA NGMCPEVPTH VTIRILTAEA GAVEGEAQRE ILAVETRFST VTWQYQCGLT
     CEEDKADLLP LSASVKFINI PAQMPRPTRF QINFTEYDCT RNELCWPQLL YPLTQYYQGE
     PRPQCVAKGL MLLSLLMLAI LLRHPWVGMC KAWSSASIQH