TECT3_MACFA
ID TECT3_MACFA Reviewed; 608 AA.
AC Q4R9E0;
DT 04-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT 19-JUL-2005, sequence version 1.
DT 03-AUG-2022, entry version 47.
DE RecName: Full=Tectonic-3;
DE Flags: Precursor;
GN Name=TCTN3; Synonyms=TECT3; ORFNames=QtsA-10216;
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RG International consortium for macaque cDNA sequencing and analysis;
RT "DNA sequences of macaque genes expressed in brain or testis and its
RT evolutionary implications.";
RL Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Part of the tectonic-like complex which is required for
CC tissue-specific ciliogenesis and may regulate ciliary membrane
CC composition. May be involved in apoptosis regulation (By similarity).
CC Necessary for signal transduction through the sonic hedgehog (Shh)
CC signaling pathway (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Part of the tectonic-like complex (also named B9 complex).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the tectonic family. {ECO:0000305}.
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DR EMBL; AB168156; BAE00281.1; -; mRNA.
DR RefSeq; NP_001271887.1; NM_001284958.1.
DR AlphaFoldDB; Q4R9E0; -.
DR STRING; 9541.XP_005566115.1; -.
DR GeneID; 101865925; -.
DR CTD; 26123; -.
DR eggNOG; ENOG502RKDI; Eukaryota.
DR OrthoDB; 446525at2759; -.
DR Proteomes; UP000233100; Unplaced.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR GO; GO:0060271; P:cilium assembly; ISS:UniProtKB.
DR GO; GO:0007224; P:smoothened signaling pathway; ISS:UniProtKB.
DR InterPro; IPR040354; Tectonic.
DR InterPro; IPR011677; Tectonic_dom.
DR PANTHER; PTHR14611; PTHR14611; 1.
DR Pfam; PF07773; DUF1619; 1.
PE 2: Evidence at transcript level;
KW Apoptosis; Cilium biogenesis/degradation; Glycoprotein; Membrane;
KW Reference proteome; Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT CHAIN 23..608
FT /note="Tectonic-3"
FT /id="PRO_0000229801"
FT TOPO_DOM 23..586
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 587..607
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 608
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 23..58
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 78
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 179
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 347
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 608 AA; 66083 MW; 279F60D659AE3470 CRC64;
MRTPQLALLQ VFLLMFPDGV RPQPSSSPSG AVPTSLDLQP GTVGGTLQSS SEATATRPAM
PGISTVVPTL VTPSAPGNRT VDLFPVLPIC VCDLTPGACD INCCCDRDCY LLHPRTVFSF
CLPGSVRSSS WVCVDNSLIF RSNSPFPSRV FMDSNGIRQF CVHVNNSKLN YFQKLQKVNA
TNFQDLAAEF GGESFTSTFQ TQSPPSFYRA GDPILTYFPK WSVISLLRQP AGVGAAGLCA
ESNPAGFLES KSTTCTRFFK NLASSCTLDS ALNAASYYNF TVLKVPRGMT DPQNMEFQVP
VTLTSQANAP LLAGNTCQNV VSQVTYEIET NGTFGIQKVS VSLGQTNLTV EPGASLQQHF
ILHFRAFQQS TAASITSPRS GNPGYIVGKP LLALTGDVSY SMTLLRSQGN GSCSVNRHEV
QFGVNAISGC KLRLKKADCS YLQQEIYQTL HGRPRPQHVA IFGNADPAQK GGWTRILNRH
CNISAIICTS CCLIPVSLEI QVLWAYVGLL SNPQAHVSGV RFLYQCQSVR DSQQVTEVSL
TTIVNFVDIT QKPEPPRGQP KMDWKLPFDF FFPFRVAFSR GVSSQKCSVS PVLILCLLLL
GVLNLETT