ID   TECT3_MACFA             Reviewed;         608 AA.
AC   Q4R9E0;
DT   04-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 1.
DT   03-AUG-2022, entry version 47.
DE   RecName: Full=Tectonic-3;
DE   Flags: Precursor;
GN   Name=TCTN3; Synonyms=TECT3; ORFNames=QtsA-10216;
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RG   International consortium for macaque cDNA sequencing and analysis;
RT   "DNA sequences of macaque genes expressed in brain or testis and its
RT   evolutionary implications.";
RL   Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Part of the tectonic-like complex which is required for
CC       tissue-specific ciliogenesis and may regulate ciliary membrane
CC       composition. May be involved in apoptosis regulation (By similarity).
CC       Necessary for signal transduction through the sonic hedgehog (Shh)
CC       signaling pathway (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Part of the tectonic-like complex (also named B9 complex).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC       membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the tectonic family. {ECO:0000305}.
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DR   EMBL; AB168156; BAE00281.1; -; mRNA.
DR   RefSeq; NP_001271887.1; NM_001284958.1.
DR   AlphaFoldDB; Q4R9E0; -.
DR   STRING; 9541.XP_005566115.1; -.
DR   GeneID; 101865925; -.
DR   CTD; 26123; -.
DR   eggNOG; ENOG502RKDI; Eukaryota.
DR   OrthoDB; 446525at2759; -.
DR   Proteomes; UP000233100; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR   GO; GO:0060271; P:cilium assembly; ISS:UniProtKB.
DR   GO; GO:0007224; P:smoothened signaling pathway; ISS:UniProtKB.
DR   InterPro; IPR040354; Tectonic.
DR   InterPro; IPR011677; Tectonic_dom.
DR   PANTHER; PTHR14611; PTHR14611; 1.
DR   Pfam; PF07773; DUF1619; 1.
PE   2: Evidence at transcript level;
KW   Apoptosis; Cilium biogenesis/degradation; Glycoprotein; Membrane;
KW   Reference proteome; Signal; Transmembrane; Transmembrane helix.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   CHAIN           23..608
FT                   /note="Tectonic-3"
FT                   /id="PRO_0000229801"
FT   TOPO_DOM        23..586
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        587..607
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        608
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          23..58
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        78
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        179
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        347
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   608 AA;  66083 MW;  279F60D659AE3470 CRC64;
     MRTPQLALLQ VFLLMFPDGV RPQPSSSPSG AVPTSLDLQP GTVGGTLQSS SEATATRPAM
     PGISTVVPTL VTPSAPGNRT VDLFPVLPIC VCDLTPGACD INCCCDRDCY LLHPRTVFSF
     CLPGSVRSSS WVCVDNSLIF RSNSPFPSRV FMDSNGIRQF CVHVNNSKLN YFQKLQKVNA
     TNFQDLAAEF GGESFTSTFQ TQSPPSFYRA GDPILTYFPK WSVISLLRQP AGVGAAGLCA
     ESNPAGFLES KSTTCTRFFK NLASSCTLDS ALNAASYYNF TVLKVPRGMT DPQNMEFQVP
     VTLTSQANAP LLAGNTCQNV VSQVTYEIET NGTFGIQKVS VSLGQTNLTV EPGASLQQHF
     ILHFRAFQQS TAASITSPRS GNPGYIVGKP LLALTGDVSY SMTLLRSQGN GSCSVNRHEV
     QFGVNAISGC KLRLKKADCS YLQQEIYQTL HGRPRPQHVA IFGNADPAQK GGWTRILNRH
     CNISAIICTS CCLIPVSLEI QVLWAYVGLL SNPQAHVSGV RFLYQCQSVR DSQQVTEVSL
     TTIVNFVDIT QKPEPPRGQP KMDWKLPFDF FFPFRVAFSR GVSSQKCSVS PVLILCLLLL
     GVLNLETT