TECT3_MOUSE
ID TECT3_MOUSE Reviewed; 595 AA.
AC Q8R2Q6; Q8CDF3; Q9CRC5;
DT 04-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 03-AUG-2022, entry version 121.
DE RecName: Full=Tectonic-3;
DE Flags: Precursor;
GN Name=Tctn3; Synonyms=Tect3;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC STRAIN=C57BL/6J;
RX PubMed=16357211; DOI=10.1101/gad.1363606;
RA Reiter J.F., Skarnes W.C.;
RT "Tectonic, a novel regulator of the Hedgehog pathway required for both
RT activation and inhibition.";
RL Genes Dev. 20:22-27(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
RC STRAIN=C57BL/6J; TISSUE=Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=FVB/N; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP INTERACTION WITH MKS1.
RX PubMed=21565611; DOI=10.1016/j.cell.2011.04.019;
RA Sang L., Miller J.J., Corbit K.C., Giles R.H., Brauer M.J., Otto E.A.,
RA Baye L.M., Wen X., Scales S.J., Kwong M., Huntzicker E.G., Sfakianos M.K.,
RA Sandoval W., Bazan J.F., Kulkarni P., Garcia-Gonzalo F.R., Seol A.D.,
RA O'Toole J.F., Held S., Reutter H.M., Lane W.S., Rafiq M.A., Noor A.,
RA Ansar M., Devi A.R., Sheffield V.C., Slusarski D.C., Vincent J.B.,
RA Doherty D.A., Hildebrandt F., Reiter J.F., Jackson P.K.;
RT "Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes
RT and pathways.";
RL Cell 145:513-528(2011).
RN [5]
RP FUNCTION, SUBCELLULAR LOCATION, AND IDENTIFICATION IN THE TECTONIC-LIKE
RP COMPLEX.
RX PubMed=21725307; DOI=10.1038/ng.891;
RA Garcia-Gonzalo F.R., Corbit K.C., Sirerol-Piquer M.S., Ramaswami G.,
RA Otto E.A., Noriega T.R., Seol A.D., Robinson J.F., Bennett C.L.,
RA Josifova D.J., Garcia-Verdugo J.M., Katsanis N., Hildebrandt F.,
RA Reiter J.F.;
RT "A transition zone complex regulates mammalian ciliogenesis and ciliary
RT membrane composition.";
RL Nat. Genet. 43:776-784(2011).
CC -!- FUNCTION: Part of the tectonic-like complex which is required for
CC tissue-specific ciliogenesis and may regulate ciliary membrane
CC composition. May be involved in apoptosis regulation (By similarity).
CC Necessary for signal transduction through the sonic hedgehog (Shh)
CC signaling pathway. {ECO:0000250, ECO:0000269|PubMed:21725307}.
CC -!- SUBUNIT: Part of the tectonic-like complex (also named B9 complex).
CC {ECO:0000269|PubMed:21725307}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q8R2Q6-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8R2Q6-2; Sequence=VSP_017769, VSP_017770;
CC Name=3;
CC IsoId=Q8R2Q6-3; Sequence=VSP_017767, VSP_017768;
CC -!- SIMILARITY: Belongs to the tectonic family. {ECO:0000305}.
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DR EMBL; DQ278871; ABB90563.1; -; mRNA.
DR EMBL; AK015861; BAB30004.1; -; mRNA.
DR EMBL; AK016982; BAB30537.1; -; mRNA.
DR EMBL; AK030156; BAC26813.1; -; mRNA.
DR EMBL; BC027335; AAH27335.1; -; mRNA.
DR EMBL; BC080805; AAH80805.1; -; mRNA.
DR CCDS; CCDS29804.1; -. [Q8R2Q6-1]
DR RefSeq; NP_080536.2; NM_026260.2. [Q8R2Q6-1]
DR AlphaFoldDB; Q8R2Q6; -.
DR BioGRID; 212298; 1.
DR CORUM; Q8R2Q6; -.
DR IntAct; Q8R2Q6; 2.
DR STRING; 10090.ENSMUSP00000025981; -.
DR GlyGen; Q8R2Q6; 2 sites.
DR iPTMnet; Q8R2Q6; -.
DR PhosphoSitePlus; Q8R2Q6; -.
DR MaxQB; Q8R2Q6; -.
DR PaxDb; Q8R2Q6; -.
DR PRIDE; Q8R2Q6; -.
DR ProteomicsDB; 262853; -. [Q8R2Q6-1]
DR ProteomicsDB; 262854; -. [Q8R2Q6-2]
DR ProteomicsDB; 262855; -. [Q8R2Q6-3]
DR Antibodypedia; 30655; 204 antibodies from 31 providers.
DR DNASU; 67590; -.
DR Ensembl; ENSMUST00000025981; ENSMUSP00000025981; ENSMUSG00000025008. [Q8R2Q6-1]
DR Ensembl; ENSMUST00000135795; ENSMUSP00000123461; ENSMUSG00000025008. [Q8R2Q6-2]
DR GeneID; 67590; -.
DR KEGG; mmu:67590; -.
DR UCSC; uc008hla.1; mouse. [Q8R2Q6-1]
DR UCSC; uc008hlb.1; mouse. [Q8R2Q6-2]
DR UCSC; uc008hlc.1; mouse. [Q8R2Q6-3]
DR CTD; 26123; -.
DR MGI; MGI:1914840; Tctn3.
DR VEuPathDB; HostDB:ENSMUSG00000025008; -.
DR eggNOG; ENOG502RKDI; Eukaryota.
DR GeneTree; ENSGT00570000079101; -.
DR HOGENOM; CLU_016974_1_0_1; -.
DR InParanoid; Q8R2Q6; -.
DR OMA; KVQFGVN; -.
DR OrthoDB; 446525at2759; -.
DR PhylomeDB; Q8R2Q6; -.
DR TreeFam; TF329169; -.
DR Reactome; R-MMU-5620912; Anchoring of the basal body to the plasma membrane.
DR BioGRID-ORCS; 67590; 3 hits in 72 CRISPR screens.
DR ChiTaRS; Tctn3; mouse.
DR PRO; PR:Q8R2Q6; -.
DR Proteomes; UP000000589; Chromosome 19.
DR RNAct; Q8R2Q6; protein.
DR Bgee; ENSMUSG00000025008; Expressed in fourth ventricle and 230 other tissues.
DR ExpressionAtlas; Q8R2Q6; baseline and differential.
DR Genevisible; Q8R2Q6; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; ISO:MGI.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR GO; GO:0060271; P:cilium assembly; IMP:UniProtKB.
DR GO; GO:0043065; P:positive regulation of apoptotic process; ISO:MGI.
DR GO; GO:0007224; P:smoothened signaling pathway; ISO:MGI.
DR InterPro; IPR040354; Tectonic.
DR InterPro; IPR011677; Tectonic_dom.
DR PANTHER; PTHR14611; PTHR14611; 1.
DR Pfam; PF07773; DUF1619; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Apoptosis; Cilium biogenesis/degradation;
KW Glycoprotein; Membrane; Reference proteome; Signal; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT CHAIN 23..595
FT /note="Tectonic-3"
FT /id="PRO_0000229802"
FT TOPO_DOM 23..575
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 576..594
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 595
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 23..62
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 167
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 336
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 355..392
FT /note="AFQQRKAAAPAAPRSGNPGYLTGKPLLVLTGDTSHSMT -> VSSLPSERVQ
FT RLSPRNSTLQSQYPHCLSVCLSEYLLFL (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_017767"
FT VAR_SEQ 393..595
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_017768"
FT VAR_SEQ 474..492
FT /note="AVNCTSCCLIPVSLEIQVL -> VRKEATTAWWLVFHLCNYA (in
FT isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_017769"
FT VAR_SEQ 493..595
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_017770"
SQ SEQUENCE 595 AA; 64824 MW; B317AF1E20F4CDF1 CRC64;
MCTLQLHLLL LVVLMLSETA RPQPSSTARA FPTSWGLEPV TPEVPTSAPP DSSESPTPWT
LSMPVNATTD PFPALPICVC DLTPGTCDLN CCCDKDCDLL HPRTVFSFCL PGSVRSSSWV
CVDNSLMFRS NSPFPSRVFT DSSGTTQFCV RVNNSKANYF QKLQTVNATN FQALAAEFGG
QSFPSMPPET QPPVLFYRAG DPILTYYPSW SVVSLLRQPA AVGAGGLCAE SNPAGFLESK
STTCPRFFRD LASSCTSEPA LDAASYYNFR VLKVPRGVTD LQNMKFQVPV TLASQASPPL
LAGNTCQNIV SQVVYEIETN GTFGIQKVSV SFRQTNLTVK PGVSLQQDFI VHFRAFQQRK
AAAPAAPRSG NPGYLTGKPL LVLTGDTSHS MTLLQSEGNG LCSAKRHAVQ FGVNAVSGCQ
LRPREVNCSH LQEEVYQTLH GRPRPEHVAV FGNADPAQRG GWTRILSRDC SVSAVNCTSC
CLIPVSLEIQ VLWAHLGLQS NPQAHVAGAR FLYQCKSVQE HQRGIEVSLT TLVNFVDITQ
KPEPPRDQPR IDWKLPFDFF FPFKAALSRG ASVQKDSLVL ILCVLLLGLL NSQTK
