ID   BRA6_CHITH              Reviewed;         453 AA.
AC   P24243; Q8MPQ2;
DT   01-MAR-1992, integrated into UniProtKB/Swiss-Prot.
DT   06-DEC-2002, sequence version 2.
DT   25-MAY-2022, entry version 54.
DE   RecName: Full=Balbiani ring A 67 kDa protein;
DE   AltName: Full=p67;
DE   Flags: Precursor;
GN   Name=F6.2;
OS   Chironomus thummi thummi (Midge).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Chironomoidea; Chironomidae;
OC   Chironominae; Chironomus.
OX   NCBI_TaxID=7155;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND SEQUENCE REVISION.
RC   TISSUE=Salivary gland;
RA   Alieva E., Mayorov V., Elisafenko E., Adkison L., Blinov A.G.;
RT   "Analysis of structure and expression of F6.2 gene in Chironomus thummi and
RT   in related species.";
RL   Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-293.
RC   TISSUE=Salivary gland;
RX   PubMed=2269433; DOI=10.1016/0378-1119(90)90259-t;
RA   Bogachev S.S., Blinov A.G., Kolesnikov N.N., Scherbik S.V., Taranin A.V.,
RA   Sebeleva T.E., Baiborodin S.I., Kiknadze I.I.;
RT   "A tissue-specific puff (Balbiani ring a) in Chironomus thummi may contain
RT   a gene encoding a 67-kDa protein which exhibits non-tissue-specific
RT   expression.";
RL   Gene 96:241-247(1990).
CC   -!- FUNCTION: Used by the larvae to construct a supramolecular structure,
CC       the larval tube.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: The 67 kDa protein is not tissue-specific. Thus,
CC       the puff Balbiani ring, which is tissue-specific, contains at least one
CC       non-tissue-specific gene.
CC   -!- MISCELLANEOUS: This ORF may only constitute one exon for the 67 kDa
CC       protein.
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DR   EMBL; AF521043; AAM77906.1; -; Genomic_DNA.
DR   PIR; JH0365; JH0365.
DR   AlphaFoldDB; P24243; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   InterPro; IPR035241; DUF5442.
DR   Pfam; PF17514; DUF5442; 1.
PE   2: Evidence at transcript level;
KW   Secreted; Signal.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255"
FT   CHAIN           24..453
FT                   /note="Balbiani ring A 67 kDa protein"
FT                   /id="PRO_0000020829"
SQ   SEQUENCE   453 AA;  52691 MW;  D6409D541FC29780 CRC64;
     MKFIIRTILI ALFLIAIINE SQCRRDPRKF RLSRVFEKLI EKNSRHHENE RENEIGRAFD
     MDCVKNFFKL PQNGKMILKE TEEMVFMVAS GMKCSTEYKI FGAMFRDFVN EGLKEHLTCL
     KWQLKQYEPS AKLIENFEIT EAELKVCQEK FPIYNEMKGF QKDLEDLLGP LNTYTCGAVS
     EDGAKDFLIF VSKGAIVEYG DISEELKKTE KEKLKDYFKD ISIKTAECHI KRFENEPQAY
     QVNDTLNYYY KKDLVPTDPD QEDPNGYYQR LIKVEEAIDK DCVKQKLTLP ENGDKAFVEP
     EATILIASAK TKCIKIDQLE FSNLFIDFAL EDGQRHDRYY SCARYKLHQL DPNSQLAVIT
     SSDKSHEKHC RHIEIRLHPF SIPINGYAES VGKLNEATCG VLTDDIVNVV TLKTMLLYDV
     KDKELKINET KELYGLVTDK LQKLARLILE RVR