TEDC1_HUMAN
ID TEDC1_HUMAN Reviewed; 495 AA.
AC Q86SX3; B5MDG3; E9PAQ4; Q86TT3; Q86TT4; Q86TT5; Q96B41; Q9H7H4;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 29-APR-2008, sequence version 2.
DT 03-AUG-2022, entry version 129.
DE RecName: Full=Tubulin epsilon and delta complex protein 1 {ECO:0000305};
GN Name=TEDC1 {ECO:0000312|HGNC:HGNC:20127};
GN Synonyms=C14orf80 {ECO:0000312|HGNC:HGNC:20127};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2; 3 AND 5).
RC TISSUE=Cervix carcinoma, and Placenta;
RA Li W.B., Gruber C., Jessee J., Polayes D.;
RT "Full-length cDNA libraries and normalization.";
RL Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12508121; DOI=10.1038/nature01348;
RA Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C.,
RA Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A.,
RA Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H.,
RA Du H., Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T.,
RA Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B.,
RA Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D.,
RA Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R.,
RA Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S.,
RA Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C.,
RA Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S.,
RA Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C.,
RA Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P.,
RA Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M.,
RA Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V.,
RA Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J.,
RA Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F.,
RA Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F.,
RA Waterston R., Hood L., Weissenbach J.;
RT "The DNA sequence and analysis of human chromosome 14.";
RL Nature 421:601-607(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
RC TISSUE=Uterus;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 327-495.
RC TISSUE=Spleen;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [6]
RP FUNCTION.
RX PubMed=28796488; DOI=10.1021/acschembio.7b00385;
RA Filipuzzi I., Thomas J.R., Pries V., Estoppey D., Salcius M., Studer C.,
RA Schirle M., Hoepfner D.;
RT "Direct Interaction of Chivosazole F with Actin Elicits Cell Responses
RT Similar to Latrunculin A but Distinct from Chondramide.";
RL ACS Chem. Biol. 12:2264-2269(2017).
CC -!- FUNCTION: Acts as a positive regulator of ciliary hedgehog signaling.
CC Required for centriole stability (By similarity). May play a role in
CC counteracting perturbation of actin filaments, such as after treatment
CC with the actin depolymerizing microbial metabolite Chivosazole F
CC (PubMed:28796488). {ECO:0000250|UniProtKB:Q3UK37,
CC ECO:0000269|PubMed:28796488}.
CC -!- SUBUNIT: Interacts with TEDC2. Found in a complex with TEDC1, TEDC2,
CC TUBE1 and TUBD1. {ECO:0000250|UniProtKB:Q3UK37}.
CC -!- SUBCELLULAR LOCATION: Cell projection, cilium
CC {ECO:0000250|UniProtKB:Q3UK37}. Cytoplasm, cytoskeleton, microtubule
CC organizing center, centrosome, centriole
CC {ECO:0000250|UniProtKB:Q3UK37}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=6;
CC Name=1;
CC IsoId=Q86SX3-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q86SX3-2; Sequence=VSP_033065;
CC Name=3;
CC IsoId=Q86SX3-3; Sequence=VSP_033063, VSP_033065;
CC Name=4;
CC IsoId=Q86SX3-4; Sequence=VSP_033062, VSP_033064, VSP_033066;
CC Name=5;
CC IsoId=Q86SX3-5; Sequence=VSP_045690, VSP_033065;
CC Name=6;
CC IsoId=Q86SX3-6; Sequence=VSP_033066;
CC -!- SEQUENCE CAUTION:
CC Sequence=CAD62351.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC Sequence=CAD62363.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC Sequence=CAD62611.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; BX161477; CAD61932.1; -; mRNA.
DR EMBL; BX248038; CAD62351.1; ALT_INIT; mRNA.
DR EMBL; BX248074; CAD62363.1; ALT_INIT; mRNA.
DR EMBL; BX248283; CAD62611.1; ALT_INIT; mRNA.
DR EMBL; AL928654; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471061; EAW81929.1; -; Genomic_DNA.
DR EMBL; BC016028; AAH16028.1; -; mRNA.
DR EMBL; AK024506; BAB15796.1; -; mRNA.
DR CCDS; CCDS45180.1; -. [Q86SX3-5]
DR CCDS; CCDS45181.1; -. [Q86SX3-6]
DR CCDS; CCDS45182.1; -. [Q86SX3-2]
DR CCDS; CCDS55955.1; -. [Q86SX3-3]
DR RefSeq; NP_001128347.1; NM_001134875.1. [Q86SX3-6]
DR RefSeq; NP_001128348.1; NM_001134876.1. [Q86SX3-2]
DR RefSeq; NP_001128349.1; NM_001134877.1. [Q86SX3-5]
DR RefSeq; NP_001185912.1; NM_001198983.1. [Q86SX3-3]
DR AlphaFoldDB; Q86SX3; -.
DR BioGRID; 129629; 231.
DR DIP; DIP-62062N; -.
DR IntAct; Q86SX3; 21.
DR iPTMnet; Q86SX3; -.
DR PhosphoSitePlus; Q86SX3; -.
DR BioMuta; TEDC1; -.
DR DMDM; 187470846; -.
DR EPD; Q86SX3; -.
DR jPOST; Q86SX3; -.
DR MassIVE; Q86SX3; -.
DR MaxQB; Q86SX3; -.
DR PaxDb; Q86SX3; -.
DR PeptideAtlas; Q86SX3; -.
DR PRIDE; Q86SX3; -.
DR ProteomicsDB; 19061; -.
DR ProteomicsDB; 6174; -.
DR ProteomicsDB; 69642; -. [Q86SX3-1]
DR ProteomicsDB; 69643; -. [Q86SX3-2]
DR ProteomicsDB; 69644; -. [Q86SX3-3]
DR ProteomicsDB; 69645; -. [Q86SX3-4]
DR Antibodypedia; 48308; 57 antibodies from 13 providers.
DR DNASU; 283643; -.
DR Ensembl; ENST00000329886.11; ENSP00000333010.7; ENSG00000185347.18. [Q86SX3-3]
DR Ensembl; ENST00000334656.11; ENSP00000333959.8; ENSG00000185347.18. [Q86SX3-4]
DR Ensembl; ENST00000354560.10; ENSP00000346568.6; ENSG00000185347.18. [Q86SX3-2]
DR Ensembl; ENST00000392522.7; ENSP00000376307.3; ENSG00000185347.18. [Q86SX3-6]
DR Ensembl; ENST00000392523.9; ENSP00000376308.4; ENSG00000185347.18. [Q86SX3-1]
DR Ensembl; ENST00000392527.5; ENSP00000376312.1; ENSG00000185347.18. [Q86SX3-5]
DR Ensembl; ENST00000450383.1; ENSP00000391436.1; ENSG00000185347.18. [Q86SX3-4]
DR GeneID; 283643; -.
DR KEGG; hsa:283643; -.
DR MANE-Select; ENST00000392523.9; ENSP00000376308.4; NM_001367178.1; NP_001354107.1.
DR UCSC; uc001yrj.4; human. [Q86SX3-1]
DR CTD; 283643; -.
DR DisGeNET; 283643; -.
DR GeneCards; TEDC1; -.
DR HGNC; HGNC:20127; TEDC1.
DR HPA; ENSG00000185347; Low tissue specificity.
DR neXtProt; NX_Q86SX3; -.
DR OpenTargets; ENSG00000185347; -.
DR PharmGKB; PA134885988; -.
DR VEuPathDB; HostDB:ENSG00000185347; -.
DR eggNOG; ENOG502RXA4; Eukaryota.
DR GeneTree; ENSGT00390000011474; -.
DR HOGENOM; CLU_052124_0_0_1; -.
DR InParanoid; Q86SX3; -.
DR OMA; SVCTCED; -.
DR OrthoDB; 1248596at2759; -.
DR PhylomeDB; Q86SX3; -.
DR TreeFam; TF330945; -.
DR PathwayCommons; Q86SX3; -.
DR SignaLink; Q86SX3; -.
DR BioGRID-ORCS; 283643; 369 hits in 1077 CRISPR screens.
DR GenomeRNAi; 283643; -.
DR Pharos; Q86SX3; Tdark.
DR PRO; PR:Q86SX3; -.
DR Proteomes; UP000005640; Chromosome 14.
DR RNAct; Q86SX3; protein.
DR Bgee; ENSG00000185347; Expressed in tendon of biceps brachii and 103 other tissues.
DR ExpressionAtlas; Q86SX3; baseline and differential.
DR Genevisible; Q86SX3; HS.
DR GO; GO:0005814; C:centriole; ISS:UniProtKB.
DR GO; GO:0005929; C:cilium; ISS:UniProtKB.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0045880; P:positive regulation of smoothened signaling pathway; ISS:UniProtKB.
DR InterPro; IPR043535; TEDC1.
DR InterPro; IPR027996; TEDC1_dom.
DR PANTHER; PTHR35076; PTHR35076; 1.
DR Pfam; PF14970; TEDC1; 2.
PE 2: Evidence at transcript level;
KW Alternative splicing; Cell projection; Coiled coil; Cytoplasm;
KW Cytoskeleton; Reference proteome.
FT CHAIN 1..495
FT /note="Tubulin epsilon and delta complex protein 1"
FT /id="PRO_0000330692"
FT REGION 417..440
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 355..387
FT /evidence="ECO:0000255"
FT COILED 452..480
FT /evidence="ECO:0000255"
FT VAR_SEQ 1..126
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_033062"
FT VAR_SEQ 1..49
FT /note="MGRRRQRVDPAAGARAGALPEAIAALSRSLPSGPSPEIFRRAKFDRPEA ->
FT MSGQRGDWVQ (in isoform 3)"
FT /evidence="ECO:0000303|Ref.1"
FT /id="VSP_033063"
FT VAR_SEQ 1..49
FT /note="MGRRRQRVDPAAGARAGALPEAIAALSRSLPSGPSPEIFRRAKFDRPEA ->
FT MSGQRGDW (in isoform 5)"
FT /evidence="ECO:0000303|Ref.1"
FT /id="VSP_045690"
FT VAR_SEQ 144..195
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_033064"
FT VAR_SEQ 196..297
FT /note="Missing (in isoform 2, isoform 3 and isoform 5)"
FT /evidence="ECO:0000303|Ref.1"
FT /id="VSP_033065"
FT VAR_SEQ 229..297
FT /note="Missing (in isoform 4 and isoform 6)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_033066"
SQ SEQUENCE 495 AA; 54231 MW; 3E34FACE82E0EACF CRC64;
MGRRRQRVDP AAGARAGALP EAIAALSRSL PSGPSPEIFR RAKFDRPEAT SALWQLLFRV
LSPLPAGNAL ASLALEVQAR LVKSALCSQG YPRLALAQLP EDGSQGSREL LLALSWLLAR
GPVPEQMLAQ ARVPLGDEMT VCQCEALASP GPPAPHMEAE GPVDVRHVQW LMGKLRFRWR
QLVSSQQEQC ALLSKIHLYT RGCHSDQSLS HLSVTEAEML RDPEGGQQVS GAGAAQNLDL
AYPKCLHSFC TPGMGPRTFW NDLWLVCEQP GLLPGDWAAP LDPGGASACS LLSPFRALLR
TLERENQRLE AVLAWRRSEL VFWRWMDTVL GTCAPEVPAA ASQPTFLPWV PERGGGELDL
VVRELQALEE ELREAAERRR AAWEAKAGGC GRGPEWSAAR RASREAVEKE LGALQQCWER
DGGPAQPHGP HRLVRREDGA AGDRDLRAAV VIRTLRSQEA CLEAVLRRLQ GQCRQELARL
VGARPGLIWI PPPGR
