TEDC1_MOUSE
ID TEDC1_MOUSE Reviewed; 420 AA.
AC Q3UK37; E9Q930; Q3TK97;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 27-JUL-2011, sequence version 2.
DT 03-AUG-2022, entry version 92.
DE RecName: Full=Tubulin epsilon and delta complex protein 1 {ECO:0000303|PubMed:29459677};
DE AltName: Full=Uncharacterized protein C14orf80 homolog;
GN Name=Tedc1 {ECO:0000312|MGI:MGI:2144738};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J, and DBA/2J;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP SUBCELLULAR LOCATION, FUNCTION, INTERACTION WITH TEDC2, SUBUNIT, AND
RP IDENTIFICATION BY MASS SPECTROMETRY.
RX PubMed=29459677; DOI=10.1038/s41588-018-0054-7;
RA Breslow D.K., Hoogendoorn S., Kopp A.R., Morgens D.W., Vu B.K.,
RA Kennedy M.C., Han K., Li A., Hess G.T., Bassik M.C., Chen J.K.,
RA Nachury M.V.;
RT "A CRISPR-based screen for Hedgehog signaling provides insights into
RT ciliary function and ciliopathies.";
RL Nat. Genet. 50:460-471(2018).
CC -!- FUNCTION: Acts as a positive regulator of ciliary hedgehog signaling.
CC Required for centriole stability (PubMed:29459677). May play a role in
CC counteracting perturbation of actin filaments, such as after treatment
CC with the actin depolymerizing microbial metabolite Chivosazole F (By
CC similarity). {ECO:0000250|UniProtKB:Q86SX3,
CC ECO:0000269|PubMed:29459677}.
CC -!- SUBUNIT: Interacts with TEDC2 (PubMed:29459677). Found in a complex
CC with TEDC1, TEDC2, TUBE1 and TUBD1 (PubMed:29459677).
CC {ECO:0000269|PubMed:29459677}.
CC -!- SUBCELLULAR LOCATION: Cell projection, cilium
CC {ECO:0000269|PubMed:29459677}. Cytoplasm, cytoskeleton, microtubule
CC organizing center, centrosome, centriole {ECO:0000269|PubMed:29459677}.
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DR EMBL; AK146189; BAE26965.1; -; mRNA.
DR EMBL; AK167092; BAE39248.1; -; mRNA.
DR EMBL; AC161112; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS49196.1; -.
DR RefSeq; NP_598802.2; NM_134041.3.
DR AlphaFoldDB; Q3UK37; -.
DR SMR; Q3UK37; -.
DR BioGRID; 222690; 1.
DR STRING; 10090.ENSMUSP00000035351; -.
DR iPTMnet; Q3UK37; -.
DR PhosphoSitePlus; Q3UK37; -.
DR PaxDb; Q3UK37; -.
DR PRIDE; Q3UK37; -.
DR ProteomicsDB; 263029; -.
DR Antibodypedia; 48308; 57 antibodies from 13 providers.
DR Ensembl; ENSMUST00000049271; ENSMUSP00000035351; ENSMUSG00000037466.
DR GeneID; 104732; -.
DR KEGG; mmu:104732; -.
DR UCSC; uc007pga.2; mouse.
DR CTD; 283643; -.
DR MGI; MGI:2144738; Tedc1.
DR VEuPathDB; HostDB:ENSMUSG00000037466; -.
DR eggNOG; ENOG502RXA4; Eukaryota.
DR GeneTree; ENSGT00390000011474; -.
DR HOGENOM; CLU_052124_0_0_1; -.
DR InParanoid; Q3UK37; -.
DR OMA; SVCTCED; -.
DR OrthoDB; 1248596at2759; -.
DR TreeFam; TF330945; -.
DR BioGRID-ORCS; 104732; 10 hits in 74 CRISPR screens.
DR ChiTaRS; Tedc1; mouse.
DR PRO; PR:Q3UK37; -.
DR Proteomes; UP000000589; Chromosome 12.
DR RNAct; Q3UK37; protein.
DR Bgee; ENSMUSG00000037466; Expressed in humerus cartilage element and 137 other tissues.
DR ExpressionAtlas; Q3UK37; baseline and differential.
DR Genevisible; Q3UK37; MM.
DR GO; GO:0005814; C:centriole; IDA:UniProtKB.
DR GO; GO:0005929; C:cilium; IDA:UniProtKB.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0045880; P:positive regulation of smoothened signaling pathway; IMP:UniProtKB.
DR InterPro; IPR043535; TEDC1.
DR InterPro; IPR027996; TEDC1_dom.
DR PANTHER; PTHR35076; PTHR35076; 1.
DR Pfam; PF14970; TEDC1; 1.
PE 1: Evidence at protein level;
KW Cell projection; Coiled coil; Cytoplasm; Cytoskeleton; Reference proteome.
FT CHAIN 1..420
FT /note="Tubulin epsilon and delta complex protein 1"
FT /id="PRO_0000330693"
FT REGION 342..369
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 276..340
FT /evidence="ECO:0000255"
FT COILED 377..409
FT /evidence="ECO:0000255"
FT CONFLICT 34
FT /note="I -> V (in Ref. 1; BAE26965)"
FT /evidence="ECO:0000305"
FT CONFLICT 146
FT /note="P -> L (in Ref. 1; BAE26965)"
FT /evidence="ECO:0000305"
FT CONFLICT 152
FT /note="E -> K (in Ref. 1; BAE26965)"
FT /evidence="ECO:0000305"
FT CONFLICT 201
FT /note="Q -> R (in Ref. 1; BAE26965)"
FT /evidence="ECO:0000305"
FT CONFLICT 229
FT /note="S -> G (in Ref. 1; BAE26965)"
FT /evidence="ECO:0000305"
FT CONFLICT 260
FT /note="P -> H (in Ref. 1; BAE26965)"
FT /evidence="ECO:0000305"
FT CONFLICT 271
FT /note="F -> V (in Ref. 1; BAE26965)"
FT /evidence="ECO:0000305"
FT CONFLICT 274
FT /note="E -> A (in Ref. 1; BAE26965)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 420 AA; 46797 MW; 69C309A2DCEBD66E CRC64;
MRRRRSRVEG AARALPEAVA ALSRCLPAGP SPEIFRRAKF DRPEAAPVLW QLLLRVLSPL
AANNTWTDLA PEAQACVVKS ALGSQGYPRS VLLQFPDGSS QGSRELLLAL SWLLARGPLL
EQLLAQTRVQ LGDQLPQWEA PTSPGPPAPF VEPKSPVDLR LVEWLMGRLR FRWRCLISSQ
QEQCILLSKI HLYTQGCHSQ QSLGHLSVAE TEMLRDPESG QQLLQALESE NIRLEAALEW
RRRELVFWQW MDTVLDTCSP ETPAVTSQPT FLPEISEGGL GELESVKQEL QALQEELREV
SEPRRAAWEA RVGGLGQGPE WSNSRKALQE AVQQELAALQ GSWEQSSTPG QPQRPHRLVR
SKDGAPRPQG LQAAEVIRTL SAKEACLKKA LHQLQRQCQQ ELARLAGALP GLIWILPPEH
