ID   TEDC2_BOVIN             Reviewed;         443 AA.
AC   Q3ZBU3;
DT   15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   15-MAY-2007, sequence version 2.
DT   25-MAY-2022, entry version 63.
DE   RecName: Full=Tubulin epsilon and delta complex protein 2 {ECO:0000305};
GN   Name=TEDC2 {ECO:0000250|UniProtKB:Q7L2K0};
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Hypothalamus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Acts as a positive regulator of ciliary hedgehog signaling.
CC       Required for centriole stability. {ECO:0000250|UniProtKB:Q6GQV0}.
CC   -!- SUBUNIT: Interacts with TEDC1. Found in a complex with TEDC1, TEDC2,
CC       TUBE1 and TUBD1. {ECO:0000250|UniProtKB:Q6GQV0}.
CC   -!- SUBCELLULAR LOCATION: Cell projection, cilium
CC       {ECO:0000250|UniProtKB:Q6GQV0}. Cytoplasm, cytoskeleton, microtubule
CC       organizing center, centrosome, centriole
CC       {ECO:0000250|UniProtKB:Q6GQV0}.
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DR   EMBL; BC103103; AAI03104.2; -; mRNA.
DR   RefSeq; NP_001192308.1; NM_001205379.1.
DR   AlphaFoldDB; Q3ZBU3; -.
DR   SMR; Q3ZBU3; -.
DR   STRING; 9913.ENSBTAP00000034529; -.
DR   PaxDb; Q3ZBU3; -.
DR   PRIDE; Q3ZBU3; -.
DR   GeneID; 616898; -.
DR   KEGG; bta:616898; -.
DR   CTD; 80178; -.
DR   eggNOG; ENOG502S5GP; Eukaryota.
DR   OrthoDB; 1494810at2759; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005814; C:centriole; ISS:UniProtKB.
DR   GO; GO:0005929; C:cilium; ISS:UniProtKB.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0045880; P:positive regulation of smoothened signaling pathway; ISS:UniProtKB.
DR   InterPro; IPR031518; DUF4693.
DR   PANTHER; PTHR14870; PTHR14870; 1.
DR   Pfam; PF15764; DUF4693; 1.
PE   2: Evidence at transcript level;
KW   Cell projection; Coiled coil; Cytoplasm; Cytoskeleton; Reference proteome.
FT   CHAIN           1..443
FT                   /note="Tubulin epsilon and delta complex protein 2"
FT                   /id="PRO_0000286556"
FT   REGION          45..72
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          93..146
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          8..33
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        106..130
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   443 AA;  48028 MW;  C8ED81B725CF07F2 CRC64;
     MLPAECSRRL VAELRDALDS CAERQRQLEQ SLRVSRRLLR VWEPAETPAP EPTPGSEINK
     EAPSSACPPS PQDLKELELL TQALEKAVRV RKGLSKAGEG VKARSLKSGS ASTATKASAP
     PSTSRCTGSR APETKPPRGV HHPWVPAKDL PGHRLLLVGD GAHMGQGAGA NKPEAGLRDQ
     QIVPQAASQV PEAFTLKDKG ALLRLPEAFR KAASRNARLP MCASSLWAQL SSMQTRDSVD
     AAAATAKTQF LQKMQTAAGL PSSMLSAAEV GRLQKACSML RLRMREELTA DPKDWTQEYR
     SLLTLEGLQA LAGQCLHRLQ ELQELRSAVV EQPQGPWPEG PPRAALPCGG GADPVWSPQL
     LLYSSTQELQ TLAALRLRVA MLDQQVHLEK VLMAELLPLL SEQEPLGRPW LALCRAAHCL
     LCEGGQRFLT VLQDEPADRL SPP