TEDC2_HUMAN
ID TEDC2_HUMAN Reviewed; 433 AA.
AC Q7L2K0; B4DXD7; Q96H61; Q9H872;
DT 15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 17-OCT-2006, sequence version 1.
DT 03-AUG-2022, entry version 111.
DE RecName: Full=Tubulin epsilon and delta complex protein 2 {ECO:0000305};
GN Name=TEDC2 {ECO:0000312|HGNC:HGNC:25849};
GN Synonyms=C16orf59 {ECO:0000312|HGNC:HGNC:25849};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Retinoblastoma, and Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RA Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.;
RT "Cloning of human full open reading frames in Gateway(TM) system entry
RT vector (pDONR201).";
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
RC TISSUE=Leiomyosarcoma, and Skin;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-159, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma, and Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
CC -!- FUNCTION: Acts as a positive regulator of ciliary hedgehog signaling.
CC Required for centriole stability. {ECO:0000250|UniProtKB:Q6GQV0}.
CC -!- SUBUNIT: Interacts with TEDC1. Found in a complex with TEDC1, TEDC2,
CC TUBE1 and TUBD1. {ECO:0000250|UniProtKB:Q6GQV0}.
CC -!- INTERACTION:
CC Q7L2K0; Q7Z3Y8: KRT27; NbExp=3; IntAct=EBI-8465456, EBI-3044087;
CC Q7L2K0; P60409: KRTAP10-7; NbExp=3; IntAct=EBI-8465456, EBI-10172290;
CC Q7L2K0; P60411: KRTAP10-9; NbExp=3; IntAct=EBI-8465456, EBI-10172052;
CC Q7L2K0; Q99750: MDFI; NbExp=3; IntAct=EBI-8465456, EBI-724076;
CC Q7L2K0; Q9NYP9: MIS18A; NbExp=3; IntAct=EBI-8465456, EBI-1104552;
CC Q7L2K0; Q7Z3S9: NOTCH2NLA; NbExp=3; IntAct=EBI-8465456, EBI-945833;
CC -!- SUBCELLULAR LOCATION: Cell projection, cilium
CC {ECO:0000250|UniProtKB:Q6GQV0}. Cytoplasm, cytoskeleton, microtubule
CC organizing center, centrosome, centriole
CC {ECO:0000250|UniProtKB:Q6GQV0}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q7L2K0-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q7L2K0-2; Sequence=VSP_025086;
CC Name=3;
CC IsoId=Q7L2K0-3; Sequence=VSP_025086, VSP_025087, VSP_025088;
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DR EMBL; AK023971; BAB14745.1; -; mRNA.
DR EMBL; AK301929; BAG63349.1; -; mRNA.
DR EMBL; CR457319; CAG33600.1; -; mRNA.
DR EMBL; CH471112; EAW85507.1; -; Genomic_DNA.
DR EMBL; BC008882; AAH08882.1; -; mRNA.
DR EMBL; BC018719; AAH18719.2; -; mRNA.
DR CCDS; CCDS10468.2; -. [Q7L2K0-1]
DR RefSeq; NP_079384.2; NM_025108.2. [Q7L2K0-1]
DR AlphaFoldDB; Q7L2K0; -.
DR BioGRID; 123160; 25.
DR IntAct; Q7L2K0; 10.
DR MINT; Q7L2K0; -.
DR STRING; 9606.ENSP00000355022; -.
DR iPTMnet; Q7L2K0; -.
DR PhosphoSitePlus; Q7L2K0; -.
DR BioMuta; TEDC2; -.
DR DMDM; 121944421; -.
DR EPD; Q7L2K0; -.
DR jPOST; Q7L2K0; -.
DR MassIVE; Q7L2K0; -.
DR MaxQB; Q7L2K0; -.
DR PaxDb; Q7L2K0; -.
DR PeptideAtlas; Q7L2K0; -.
DR PRIDE; Q7L2K0; -.
DR ProteomicsDB; 68763; -. [Q7L2K0-1]
DR ProteomicsDB; 68764; -. [Q7L2K0-2]
DR ProteomicsDB; 68765; -. [Q7L2K0-3]
DR Antibodypedia; 62154; 22 antibodies from 10 providers.
DR DNASU; 80178; -.
DR Ensembl; ENST00000361837.9; ENSP00000355022.4; ENSG00000162062.15. [Q7L2K0-1]
DR Ensembl; ENST00000483320.5; ENSP00000456478.1; ENSG00000162062.15. [Q7L2K0-2]
DR GeneID; 80178; -.
DR KEGG; hsa:80178; -.
DR MANE-Select; ENST00000361837.9; ENSP00000355022.4; NM_025108.3; NP_079384.2.
DR UCSC; uc002cqh.4; human. [Q7L2K0-1]
DR CTD; 80178; -.
DR DisGeNET; 80178; -.
DR GeneCards; TEDC2; -.
DR HGNC; HGNC:25849; TEDC2.
DR HPA; ENSG00000162062; Tissue enhanced (bone marrow, testis).
DR neXtProt; NX_Q7L2K0; -.
DR OpenTargets; ENSG00000162062; -.
DR PharmGKB; PA143485396; -.
DR VEuPathDB; HostDB:ENSG00000162062; -.
DR eggNOG; ENOG502S5GP; Eukaryota.
DR GeneTree; ENSGT00390000011149; -.
DR HOGENOM; CLU_052591_0_0_1; -.
DR InParanoid; Q7L2K0; -.
DR OMA; KDWMQEY; -.
DR OrthoDB; 1494810at2759; -.
DR PhylomeDB; Q7L2K0; -.
DR TreeFam; TF337397; -.
DR PathwayCommons; Q7L2K0; -.
DR SignaLink; Q7L2K0; -.
DR BioGRID-ORCS; 80178; 242 hits in 1060 CRISPR screens.
DR GenomeRNAi; 80178; -.
DR Pharos; Q7L2K0; Tdark.
DR PRO; PR:Q7L2K0; -.
DR Proteomes; UP000005640; Chromosome 16.
DR RNAct; Q7L2K0; protein.
DR Bgee; ENSG00000162062; Expressed in mucosa of transverse colon and 93 other tissues.
DR ExpressionAtlas; Q7L2K0; baseline and differential.
DR Genevisible; Q7L2K0; HS.
DR GO; GO:0005814; C:centriole; ISS:UniProtKB.
DR GO; GO:0005929; C:cilium; ISS:UniProtKB.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0045880; P:positive regulation of smoothened signaling pathway; ISS:UniProtKB.
DR InterPro; IPR031518; DUF4693.
DR PANTHER; PTHR14870; PTHR14870; 1.
DR Pfam; PF15764; DUF4693; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Cell projection; Cytoplasm; Cytoskeleton;
KW Phosphoprotein; Reference proteome.
FT CHAIN 1..433
FT /note="Tubulin epsilon and delta complex protein 2"
FT /id="PRO_0000286557"
FT REGION 45..69
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 95..169
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 326..345
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 107..124
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 159
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT VAR_SEQ 1..167
FT /note="Missing (in isoform 2 and isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:15489334, ECO:0000303|Ref.2"
FT /id="VSP_025086"
FT VAR_SEQ 323..362
FT /note="VAEQPPRPCPVGRPPGASPSCGGRAEPAWSPQLLVYSSTQ -> PRSCRPWR
FT PSSCEWLCWTSRSTWKRCFWKRRWGCNRGPQP (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_025087"
FT VAR_SEQ 363..433
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_025088"
FT VARIANT 346
FT /note="R -> K (in dbSNP:rs34948268)"
FT /id="VAR_032115"
SQ SEQUENCE 433 AA; 46402 MW; 2B3C8B18D497D728 CRC64;
MLPAGCSRRL VAELQGALDA CAQRQLQLEQ SLRVCRRLLH AWEPTGTRAL KPPPGPETNG
EDPLPACTPS PQDLKELEFL TQALEKAVRV RRGITKAGER DKAPSLKSRS IVTSSGTTAS
APPHSPGQAG GHASDTRPTK GLRQTTVPAK GHPERRLLSV GDGTRVGMGA RTPRPGAGLR
DQQMAPSAAP QAPEAFTLKE KGHLLRLPAA FRKAASQNSS LWAQLSSTQT SDSTDAAAAK
TQFLQNMQTA SGGPQPRLSA VEVEAEAGRL RKACSLLRLR MREELSAAPM DWMQEYRCLL
TLEGLQAMVG QCLHRLQELR AAVAEQPPRP CPVGRPPGAS PSCGGRAEPA WSPQLLVYSS
TQELQTLAAL KLRVAVLDQQ IHLEKVLMAE LLPLVSAAQP QGPPWLALCR AVHSLLCEGG
ARVLTILRDE PAV
