TEDC2_MOUSE
ID TEDC2_MOUSE Reviewed; 436 AA.
AC Q6GQV0; Q9DAZ6;
DT 15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 19-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 105.
DE RecName: Full=Tubulin epsilon and delta complex protein 2 {ECO:0000303|PubMed:29459677};
GN Name=Tedc2 {ECO:0000312|MGI:MGI:1919266};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=C57BL/6J; TISSUE=Embryonic liver, and Placenta;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=C57BL/6J; TISSUE=Embryonic brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP SUBCELLULAR LOCATION, FUNCTION, INTERACTION WITH TEDC1, SUBUNIT, AND
RP IDENTIFICATION BY MASS SPECTROMETRY.
RX PubMed=29459677; DOI=10.1038/s41588-018-0054-7;
RA Breslow D.K., Hoogendoorn S., Kopp A.R., Morgens D.W., Vu B.K.,
RA Kennedy M.C., Han K., Li A., Hess G.T., Bassik M.C., Chen J.K.,
RA Nachury M.V.;
RT "A CRISPR-based screen for Hedgehog signaling provides insights into
RT ciliary function and ciliopathies.";
RL Nat. Genet. 50:460-471(2018).
CC -!- FUNCTION: Acts as a positive regulator of ciliary hedgehog signaling.
CC Required for centriole stability. {ECO:0000269|PubMed:29459677}.
CC -!- SUBUNIT: Interacts with TEDC1 (PubMed:29459677). Found in a complex
CC with TEDC1, TEDC2, TUBE1 and TUBD1 (PubMed:29459677).
CC {ECO:0000269|PubMed:29459677}.
CC -!- SUBCELLULAR LOCATION: Cell projection, cilium
CC {ECO:0000269|PubMed:29459677}. Cytoplasm, cytoskeleton, microtubule
CC organizing center, centrosome, centriole {ECO:0000269|PubMed:29459677}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q6GQV0-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q6GQV0-2; Sequence=VSP_025089;
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DR EMBL; AK005395; BAB23999.1; -; mRNA.
DR EMBL; AK146539; BAE27244.1; -; mRNA.
DR EMBL; BC072612; AAH72612.1; -; mRNA.
DR CCDS; CCDS28479.1; -. [Q6GQV0-1]
DR RefSeq; NP_082332.1; NM_028056.1. [Q6GQV0-1]
DR RefSeq; XP_011244935.1; XM_011246633.1.
DR RefSeq; XP_017173142.1; XM_017317653.1.
DR AlphaFoldDB; Q6GQV0; -.
DR SMR; Q6GQV0; -.
DR BioGRID; 215094; 201.
DR STRING; 10090.ENSMUSP00000024930; -.
DR iPTMnet; Q6GQV0; -.
DR PhosphoSitePlus; Q6GQV0; -.
DR PaxDb; Q6GQV0; -.
DR PRIDE; Q6GQV0; -.
DR ProteomicsDB; 263100; -. [Q6GQV0-1]
DR ProteomicsDB; 263101; -. [Q6GQV0-2]
DR Antibodypedia; 62154; 22 antibodies from 10 providers.
DR DNASU; 72016; -.
DR Ensembl; ENSMUST00000024930; ENSMUSP00000024930; ENSMUSG00000024118. [Q6GQV0-1]
DR GeneID; 72016; -.
DR KEGG; mmu:72016; -.
DR UCSC; uc008ava.1; mouse. [Q6GQV0-1]
DR CTD; 80178; -.
DR MGI; MGI:1919266; Tedc2.
DR VEuPathDB; HostDB:ENSMUSG00000024118; -.
DR eggNOG; ENOG502S5GP; Eukaryota.
DR GeneTree; ENSGT00390000011149; -.
DR HOGENOM; CLU_052591_0_0_1; -.
DR InParanoid; Q6GQV0; -.
DR OMA; KDWMQEY; -.
DR OrthoDB; 1494810at2759; -.
DR PhylomeDB; Q6GQV0; -.
DR TreeFam; TF337397; -.
DR BioGRID-ORCS; 72016; 12 hits in 74 CRISPR screens.
DR ChiTaRS; Tedc2; mouse.
DR PRO; PR:Q6GQV0; -.
DR Proteomes; UP000000589; Chromosome 17.
DR RNAct; Q6GQV0; protein.
DR Bgee; ENSMUSG00000024118; Expressed in left lobe of liver and 160 other tissues.
DR ExpressionAtlas; Q6GQV0; baseline and differential.
DR Genevisible; Q6GQV0; MM.
DR GO; GO:0005814; C:centriole; IDA:UniProtKB.
DR GO; GO:0005929; C:cilium; IDA:UniProtKB.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0045880; P:positive regulation of smoothened signaling pathway; IMP:UniProtKB.
DR InterPro; IPR031518; DUF4693.
DR PANTHER; PTHR14870; PTHR14870; 1.
DR Pfam; PF15764; DUF4693; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Cell projection; Cytoplasm; Cytoskeleton;
KW Phosphoprotein; Reference proteome.
FT CHAIN 1..436
FT /note="Tubulin epsilon and delta complex protein 2"
FT /id="PRO_0000286558"
FT REGION 53..76
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 94..191
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 102..118
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 151..169
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 170..191
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 161
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q7L2K0"
FT VAR_SEQ 1..185
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_025089"
SQ SEQUENCE 436 AA; 47848 MW; C85B2137E6A9AA8D CRC64;
MLGVKGNYLL PADCAHRLVA ELQGALDSCA DRQRQLERSL RVSRRLLQVW EPARTPSPVP
ETKEEDPSPA CAPSSQDLEE LELLTQALEK AVRVRKGVSN AGQRDRTPTL TSKAATSGAA
AASHPRAPSR GGSRVLGTRS TKGIQRATAP PKDYPEHRLR SKGDKTHVRT QDQTTGYGPD
LRDQQMTPSS AHHTTELFAL KEKGTLLQLP EDFRKAVSRN SCLWAQLNSA RTNDSTDATR
AAKTQFLHKL QMASGCSSHR PSATEVEAHA RILRKACMLL RLRMQKELAI APTDWMQEYR
CLLTLEGLQT VVGQCLHRIQ VLQAAVTEQL PGECLAETRT QASSVCGGEV DSACSPELLL
YASTEELQTL ATLKLQVALL HQQIHLEKVL MAELLPLINT QDPGGPPWLA LCRAAYSLLC
EGGERFLTVL RDDPAD
