TEDM1_HUMAN
ID TEDM1_HUMAN Reviewed; 273 AA.
AC Q5T9Z0; Q8IVJ0;
DT 23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 21-DEC-2004, sequence version 1.
DT 03-AUG-2022, entry version 103.
DE RecName: Full=Transmembrane epididymal protein 1;
DE AltName: Full=Human epididymis-specific protein 9;
DE Short=He9;
GN Name=TEDDM1; Synonyms=HE9;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Epididymis;
RA Davies B., Davies M., Obermann H., Spiess A.N., Kirchhoff C.;
RT "Novel epididymis-specific mRNAs down-regulated by HE6/Gpr64 receptor gene
RT disruption.";
RL Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the TMEM45 family. {ECO:0000305}.
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DR EMBL; AJ515384; CAD56348.2; -; mRNA.
DR EMBL; AL139344; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471067; EAW91123.1; -; Genomic_DNA.
DR CCDS; CCDS30953.1; -.
DR RefSeq; NP_741997.3; NM_172000.3.
DR AlphaFoldDB; Q5T9Z0; -.
DR SMR; Q5T9Z0; -.
DR BioGRID; 126075; 1.
DR STRING; 9606.ENSP00000356536; -.
DR BioMuta; TEDDM1; -.
DR DMDM; 74745756; -.
DR MassIVE; Q5T9Z0; -.
DR PaxDb; Q5T9Z0; -.
DR PeptideAtlas; Q5T9Z0; -.
DR PRIDE; Q5T9Z0; -.
DR DNASU; 127670; -.
DR Ensembl; ENST00000367565.2; ENSP00000356536.1; ENSG00000203730.3.
DR GeneID; 127670; -.
DR KEGG; hsa:127670; -.
DR MANE-Select; ENST00000367565.2; ENSP00000356536.1; NM_172000.4; NP_741997.3.
DR UCSC; uc001gpe.3; human.
DR CTD; 127670; -.
DR GeneCards; TEDDM1; -.
DR HGNC; HGNC:30233; TEDDM1.
DR HPA; ENSG00000203730; Tissue enriched (epididymis).
DR neXtProt; NX_Q5T9Z0; -.
DR OpenTargets; ENSG00000203730; -.
DR PharmGKB; PA142670818; -.
DR VEuPathDB; HostDB:ENSG00000203730; -.
DR eggNOG; ENOG502QS1R; Eukaryota.
DR GeneTree; ENSGT00940000161715; -.
DR HOGENOM; CLU_059568_1_0_1; -.
DR InParanoid; Q5T9Z0; -.
DR OMA; MGKFIGH; -.
DR OrthoDB; 1297629at2759; -.
DR PhylomeDB; Q5T9Z0; -.
DR TreeFam; TF328673; -.
DR PathwayCommons; Q5T9Z0; -.
DR BioGRID-ORCS; 127670; 12 hits in 1062 CRISPR screens.
DR GenomeRNAi; 127670; -.
DR Pharos; Q5T9Z0; Tdark.
DR PRO; PR:Q5T9Z0; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q5T9Z0; protein.
DR Bgee; ENSG00000203730; Expressed in corpus epididymis and 14 other tissues.
DR Genevisible; Q5T9Z0; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR006904; DUF716.
DR Pfam; PF04819; DUF716; 1.
PE 2: Evidence at transcript level;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..273
FT /note="Transmembrane epididymal protein 1"
FT /id="PRO_0000307129"
FT TRANSMEM 34..54
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 72..92
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 96..116
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 129..149
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 158..178
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 195..215
FT /note="Helical"
FT /evidence="ECO:0000255"
FT VARIANT 130
FT /note="Y -> H (in dbSNP:rs6674281)"
FT /id="VAR_035356"
FT CONFLICT 7
FT /note="L -> V (in Ref. 1; CAD56348)"
FT /evidence="ECO:0000305"
FT CONFLICT 21
FT /note="A -> S (in Ref. 1; CAD56348)"
FT /evidence="ECO:0000305"
FT CONFLICT 27
FT /note="A -> S (in Ref. 1; CAD56348)"
FT /evidence="ECO:0000305"
FT CONFLICT 43
FT /note="Y -> N (in Ref. 1; CAD56348)"
FT /evidence="ECO:0000305"
FT CONFLICT 50
FT /note="G -> S (in Ref. 1; CAD56348)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 273 AA; 31315 MW; 26F702808C5EA5E5 CRC64;
MILKGCLLYP LCSPRNKQRC ARLWKIAYGG LLKIVTGSLL TFYVVLCLDG GMVLMRKQVP
SRFMYPKEWQ HLTMFILLTL NGCVDFMSKN VLPQRCVGLE KGTLVLIIYE LLLLMVSHVK
DSEGVELHVY SLLILVVFLL LLVLTAELWA PNMCHLQLME TFLILMMGSW LMQAGFILYR
PVSGYPWQDD DISDIMFVTT FFCWHVMINA SFLLGIYGFS SFWYHCFRPS LKLTGPKEAP
YYASTPGPLY KLLQEVEQSE KEDQALLLPK SSP
