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TEE6_STRP6
ID   TEE6_STRP6              Reviewed;         537 AA.
AC   P18481; Q5XE68;
DT   01-NOV-1990, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 2.
DT   25-MAY-2022, entry version 128.
DE   RecName: Full=Trypsin-resistant surface T6 protein;
DE   AltName: Full=T6 antigen;
DE   Flags: Precursor;
GN   Name=tee6; OrderedLocusNames=M6_Spy0160;
OS   Streptococcus pyogenes serotype M6 (strain ATCC BAA-946 / MGAS10394).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=286636;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=D471 / Serotype M6;
RX   PubMed=2188957; DOI=10.1128/jb.172.6.3310-3317.1990;
RA   Schneewind O., Jones K.F., Fischetti V.A.;
RT   "Sequence and structural characteristics of the trypsin-resistant T6
RT   surface protein of group A streptococci.";
RL   J. Bacteriol. 172:3310-3317(1990).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=11854196; DOI=10.1128/iai.70.3.1159-1167.2002;
RA   Bessen D.E., Kalia A.;
RT   "Genomic localization of a T serotype locus to a recombinatorial zone
RT   encoding extracellular matrix-binding proteins in Streptococcus pyogenes.";
RL   Infect. Immun. 70:1159-1167(2002).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-946 / MGAS10394;
RX   PubMed=15272401; DOI=10.1086/422697;
RA   Banks D.J., Porcella S.F., Barbian K.D., Beres S.B., Philips L.E.,
RA   Voyich J.M., DeLeo F.R., Martin J.M., Somerville G.A., Musser J.M.;
RT   "Progress toward characterization of the group A Streptococcus metagenome:
RT   complete genome sequence of a macrolide-resistant serotype M6 strain.";
RL   J. Infect. Dis. 190:727-738(2004).
CC   -!- INTERACTION:
CC       P18481; Q5XE69: M6_Spy0159; NbExp=2; IntAct=EBI-5260395, EBI-5260633;
CC   -!- SUBCELLULAR LOCATION: Secreted, cell wall {ECO:0000255|PROSITE-
CC       ProRule:PRU00477}; Peptidoglycan-anchor {ECO:0000255|PROSITE-
CC       ProRule:PRU00477}.
CC   -!- MISCELLANEOUS: More than 25 serologically different T antigens are
CC       found to be expressed independently of M protein, but certain T
CC       proteins occur only in association with specific M serotypes (i.e. T6
CC       protein is always found on M6 streptococcal strains).
CC   -!- MISCELLANEOUS: The T protein is exposed on the cell surface when
CC       fibrillar M protein is enzymatically removed.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAT86295.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; M32978; AAA27019.1; -; Genomic_DNA.
DR   EMBL; AY049087; AAL11467.1; -; Genomic_DNA.
DR   EMBL; CP000003; AAT86295.1; ALT_INIT; Genomic_DNA.
DR   PIR; A35400; A35400.
DR   RefSeq; WP_021340359.1; NC_006086.1.
DR   PDB; 4P0D; X-ray; 1.90 A; A=21-508.
DR   PDBsum; 4P0D; -.
DR   AlphaFoldDB; P18481; -.
DR   SMR; P18481; -.
DR   IntAct; P18481; 1.
DR   EnsemblBacteria; AAT86295; AAT86295; M6_Spy0160.
DR   KEGG; spa:M6_Spy0160; -.
DR   HOGENOM; CLU_028873_3_0_9; -.
DR   Proteomes; UP000001167; Chromosome.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.10; -; 1.
DR   InterPro; IPR032334; GramPos_pilinBB.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR019931; LPXTG_anchor.
DR   InterPro; IPR041033; Prealbumin-like.
DR   InterPro; IPR041184; T6_Ig-like.
DR   Pfam; PF00746; Gram_pos_anchor; 1.
DR   Pfam; PF16569; GramPos_pilinBB; 1.
DR   Pfam; PF17802; SpaA; 1.
DR   Pfam; PF18002; T6_Ig_like; 1.
DR   PROSITE; PS50847; GRAM_POS_ANCHORING; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Cell wall; Peptidoglycan-anchor; Secreted; Signal.
FT   SIGNAL          1..22
FT   CHAIN           23..507
FT                   /note="Trypsin-resistant surface T6 protein"
FT                   /id="PRO_0000005671"
FT   PROPEP          508..537
FT                   /note="Removed by sortase"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00477"
FT                   /id="PRO_0000005672"
FT   REGION          310..330
FT                   /note="Hydrophilic"
FT   MOTIF           504..508
FT                   /note="LPXTG sorting signal"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00477"
FT   MOD_RES         507
FT                   /note="Pentaglycyl murein peptidoglycan amidated threonine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00477"
FT   CONFLICT        318
FT                   /note="K -> R (in Ref. 1 and 2)"
FT                   /evidence="ECO:0000305"
FT   STRAND          26..32
FT                   /evidence="ECO:0007829|PDB:4P0D"
FT   STRAND          39..50
FT                   /evidence="ECO:0007829|PDB:4P0D"
FT   STRAND          56..62
FT                   /evidence="ECO:0007829|PDB:4P0D"
FT   HELIX           75..87
FT                   /evidence="ECO:0007829|PDB:4P0D"
FT   STRAND          88..90
FT                   /evidence="ECO:0007829|PDB:4P0D"
FT   STRAND          93..98
FT                   /evidence="ECO:0007829|PDB:4P0D"
FT   STRAND          104..120
FT                   /evidence="ECO:0007829|PDB:4P0D"
FT   STRAND          131..136
FT                   /evidence="ECO:0007829|PDB:4P0D"
FT   STRAND          158..161
FT                   /evidence="ECO:0007829|PDB:4P0D"
FT   STRAND          168..175
FT                   /evidence="ECO:0007829|PDB:4P0D"
FT   STRAND          177..179
FT                   /evidence="ECO:0007829|PDB:4P0D"
FT   STRAND          182..184
FT                   /evidence="ECO:0007829|PDB:4P0D"
FT   STRAND          190..198
FT                   /evidence="ECO:0007829|PDB:4P0D"
FT   STRAND          211..216
FT                   /evidence="ECO:0007829|PDB:4P0D"
FT   STRAND          221..232
FT                   /evidence="ECO:0007829|PDB:4P0D"
FT   STRAND          244..247
FT                   /evidence="ECO:0007829|PDB:4P0D"
FT   STRAND          250..257
FT                   /evidence="ECO:0007829|PDB:4P0D"
FT   STRAND          259..266
FT                   /evidence="ECO:0007829|PDB:4P0D"
FT   HELIX           268..271
FT                   /evidence="ECO:0007829|PDB:4P0D"
FT   STRAND          277..284
FT                   /evidence="ECO:0007829|PDB:4P0D"
FT   STRAND          299..306
FT                   /evidence="ECO:0007829|PDB:4P0D"
FT   STRAND          316..318
FT                   /evidence="ECO:0007829|PDB:4P0D"
FT   STRAND          326..331
FT                   /evidence="ECO:0007829|PDB:4P0D"
FT   STRAND          334..336
FT                   /evidence="ECO:0007829|PDB:4P0D"
FT   STRAND          338..346
FT                   /evidence="ECO:0007829|PDB:4P0D"
FT   TURN            347..349
FT                   /evidence="ECO:0007829|PDB:4P0D"
FT   STRAND          357..362
FT                   /evidence="ECO:0007829|PDB:4P0D"
FT   STRAND          367..372
FT                   /evidence="ECO:0007829|PDB:4P0D"
FT   STRAND          377..380
FT                   /evidence="ECO:0007829|PDB:4P0D"
FT   STRAND          386..395
FT                   /evidence="ECO:0007829|PDB:4P0D"
FT   STRAND          407..412
FT                   /evidence="ECO:0007829|PDB:4P0D"
FT   TURN            413..415
FT                   /evidence="ECO:0007829|PDB:4P0D"
FT   STRAND          418..420
FT                   /evidence="ECO:0007829|PDB:4P0D"
FT   STRAND          428..431
FT                   /evidence="ECO:0007829|PDB:4P0D"
FT   HELIX           433..435
FT                   /evidence="ECO:0007829|PDB:4P0D"
FT   HELIX           437..439
FT                   /evidence="ECO:0007829|PDB:4P0D"
FT   STRAND          444..447
FT                   /evidence="ECO:0007829|PDB:4P0D"
FT   STRAND          450..453
FT                   /evidence="ECO:0007829|PDB:4P0D"
FT   HELIX           454..456
FT                   /evidence="ECO:0007829|PDB:4P0D"
FT   STRAND          464..470
FT                   /evidence="ECO:0007829|PDB:4P0D"
FT   STRAND          480..482
FT                   /evidence="ECO:0007829|PDB:4P0D"
FT   STRAND          487..491
FT                   /evidence="ECO:0007829|PDB:4P0D"
FT   STRAND          496..498
FT                   /evidence="ECO:0007829|PDB:4P0D"
SQ   SEQUENCE   537 AA;  57647 MW;  70F7251EEFDBF644 CRC64;
     MLACLAILAV VGLGMTRVSA LSKDDTAQLK ITNIEGGPTV TLYKIGEGVY NTNGDSFINF
     KYAEGVSLTE TGPTSQEITT IANGINTGKI KPFSTENVSI SNGTATYNAR GASVYIALLT
     GATDGRTYNP ILLAASYNGE GNLVTKNIDS KSNYLYGQTS VAKSSLPSIT KKVTGTIDDV
     NKKTTSLGSV LSYSLTFELP SYTKEAVNKT VYVSDNMSEG LTFNFNSLTV EWKGKMANIT
     EDGSVMVENT KIGIAKEVNN GFNLSFIYDS LESISPNISY KAVVNNKAIV GEEGNPNKAE
     FFYSNNPTKG NTYDNLDKKP DKGNGITSKE DSKIVYTYQI AFRKVDSVSK TPLIGAIFGV
     YDTSNKLIDI VTTNKNGYAI STQVSSGKYK IKELKAPKGY SLNTETYEIT ANWVTATVKT
     SANSKSTTYT SDKNKATDNS EQVGWLKNGI FYSIDSRPTG NDVKEAYIES TKALTDGTTF
     SKSNEGSGTV LLETDIPNTK LGELPSTGSI GTYLFKAIGS AAMIGAIGIY IVKRRKA
 
 
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