TEFF1_MOUSE
ID TEFF1_MOUSE Reviewed; 372 AA.
AC Q6PFE7; A2AJN3; Q8BRP7; Q8C536; Q9JJS1;
DT 01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 134.
DE RecName: Full=Tomoregulin-1;
DE Short=TR-1;
DE AltName: Full=M7365;
DE AltName: Full=Transmembrane protein with EGF-like and one follistatin-like domain;
DE Flags: Precursor;
GN Name=Tmeff1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=C57BL/6J;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 28-372 (ISOFORM 2), TISSUE SPECIFICITY, AND
RP DEVELOPMENTAL STAGE.
RC TISSUE=Brain;
RX PubMed=11025219; DOI=10.1016/s0925-4773(00)00426-3;
RA Eib D.W., Holling T.M., Zwijsen A., Dewulf N., de Groot E.,
RA van den Eijnden-van Raaij A.J.M., Huylebroeck D., Martens G.J.M.;
RT "Expression of the follistatin/EGF-containing transmembrane protein M7365
RT (tomoregulin-1) during mouse development.";
RL Mech. Dev. 97:167-171(2000).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 118-372 (ISOFORM 2), AND
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 125-372 (ISOFORM 3).
RC STRAIN=C57BL/6J; TISSUE=Brain cortex, and Spinal cord;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [5]
RP TISSUE SPECIFICITY.
RX PubMed=11165370; DOI=10.1016/s0169-328x(00)00257-6;
RA Kanemoto N., Horie M., Omori K., Nishino N., Kondo M., Noguchi K.,
RA Tanigami A.;
RT "Expression of TMEFF1 mRNA in the mouse central nervous system: precise
RT examination and comparative studies of TMEFF1 and TMEFF2.";
RL Brain Res. Mol. Brain Res. 86:48-55(2001).
RN [6]
RP DEVELOPMENTAL STAGE.
RX PubMed=11404089; DOI=10.1016/s0925-4773(01)00362-8;
RA Morais da Silva S., Gates P.B., Eib D.W., Martens G.J.M., Brockes J.P.;
RT "The expression pattern of tomoregulin-1 in urodele limb regeneration and
RT mouse limb development.";
RL Mech. Dev. 104:125-128(2001).
CC -!- FUNCTION: May inhibit NODAL and BMP signaling during neural patterning.
CC {ECO:0000250}.
CC -!- SUBUNIT: May interact with ST14. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type I
CC membrane protein {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q6PFE7-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q6PFE7-2; Sequence=VSP_024960;
CC Name=3;
CC IsoId=Q6PFE7-3; Sequence=VSP_024960, VSP_024961;
CC -!- TISSUE SPECIFICITY: Expressed in brain, neurointermediate lobe, pars
CC distalis, pancreas, ovary and testis. {ECO:0000269|PubMed:11025219,
CC ECO:0000269|PubMed:11165370}.
CC -!- DEVELOPMENTAL STAGE: At 8.5 dpc, highly expressed in the first
CC branchial arch, somites, splanchnic mesoderm and ventral foregut
CC epithelium. At 9.5 dpc, highly expressed in motor neurons and
CC superficial neurons from the neural tube, and in the dorsal part of
CC diencephalon and mesencephalon. At 11.5 dpc and 12.5 dpc, expressed in
CC limbs. At 15.5 dpc, highly expressed in brain and spinal cord.
CC {ECO:0000269|PubMed:11025219, ECO:0000269|PubMed:11404089}.
CC -!- SIMILARITY: Belongs to the tomoregulin family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAB90827.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AL772151; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL807771; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC057598; AAH57598.1; -; mRNA.
DR EMBL; AJ400622; CAB90827.1; ALT_INIT; mRNA.
DR EMBL; AK043792; BAC31655.1; -; mRNA.
DR EMBL; AK079633; BAC37709.1; -; mRNA.
DR CCDS; CCDS18168.1; -. [Q6PFE7-1]
DR RefSeq; NP_067411.1; NM_021436.2. [Q6PFE7-1]
DR RefSeq; XP_006537899.1; XM_006537836.1.
DR RefSeq; XP_006537900.1; XM_006537837.1. [Q6PFE7-3]
DR AlphaFoldDB; Q6PFE7; -.
DR STRING; 10090.ENSMUSP00000030032; -.
DR MEROPS; I01.974; -.
DR MEROPS; I01.978; -.
DR GlyConnect; 2434; 1 N-Linked glycan (1 site). [Q6PFE7-2]
DR GlyGen; Q6PFE7; 1 site, 1 N-linked glycan (1 site).
DR iPTMnet; Q6PFE7; -.
DR PhosphoSitePlus; Q6PFE7; -.
DR MaxQB; Q6PFE7; -.
DR PaxDb; Q6PFE7; -.
DR PeptideAtlas; Q6PFE7; -.
DR PRIDE; Q6PFE7; -.
DR ProteomicsDB; 263156; -. [Q6PFE7-1]
DR ProteomicsDB; 263157; -. [Q6PFE7-2]
DR ProteomicsDB; 263158; -. [Q6PFE7-3]
DR Antibodypedia; 34902; 215 antibodies from 22 providers.
DR DNASU; 230157; -.
DR Ensembl; ENSMUST00000030032; ENSMUSP00000030032; ENSMUSG00000028347. [Q6PFE7-1]
DR Ensembl; ENSMUST00000123476; ENSMUSP00000115841; ENSMUSG00000028347. [Q6PFE7-1]
DR GeneID; 230157; -.
DR KEGG; mmu:230157; -.
DR UCSC; uc008svk.1; mouse. [Q6PFE7-1]
DR UCSC; uc008svl.1; mouse. [Q6PFE7-2]
DR CTD; 8577; -.
DR MGI; MGI:1926810; Tmeff1.
DR VEuPathDB; HostDB:ENSMUSG00000028347; -.
DR eggNOG; KOG3649; Eukaryota.
DR GeneTree; ENSGT00940000160714; -.
DR InParanoid; Q6PFE7; -.
DR OMA; DSTCRYG; -.
DR OrthoDB; 773030at2759; -.
DR PhylomeDB; Q6PFE7; -.
DR TreeFam; TF330868; -.
DR BioGRID-ORCS; 230157; 2 hits in 73 CRISPR screens.
DR ChiTaRS; Tmeff1; mouse.
DR PRO; PR:Q6PFE7; -.
DR Proteomes; UP000000589; Chromosome 4.
DR RNAct; Q6PFE7; protein.
DR Bgee; ENSMUSG00000028347; Expressed in cortical plate and 243 other tissues.
DR ExpressionAtlas; Q6PFE7; baseline and differential.
DR Genevisible; Q6PFE7; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR GO; GO:0009887; P:animal organ morphogenesis; IBA:GO_Central.
DR GO; GO:0007528; P:neuromuscular junction development; IBA:GO_Central.
DR GO; GO:0043113; P:receptor clustering; IBA:GO_Central.
DR GO; GO:0009888; P:tissue development; IBA:GO_Central.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR002350; Kazal_dom.
DR InterPro; IPR036058; Kazal_dom_sf.
DR Pfam; PF07648; Kazal_2; 2.
DR SMART; SM00280; KAZAL; 2.
DR SUPFAM; SSF100895; SSF100895; 2.
DR PROSITE; PS00022; EGF_1; 1.
DR PROSITE; PS01186; EGF_2; 1.
DR PROSITE; PS50026; EGF_3; 2.
DR PROSITE; PS51465; KAZAL_2; 2.
PE 2: Evidence at transcript level;
KW Alternative splicing; Cell membrane; Developmental protein; Disulfide bond;
KW EGF-like domain; Glycoprotein; Membrane; Reference proteome; Repeat;
KW Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..35
FT /evidence="ECO:0000255"
FT CHAIN 36..372
FT /note="Tomoregulin-1"
FT /id="PRO_0000286057"
FT TOPO_DOM 36..322
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 323..343
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 344..372
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 85..137
FT /note="Kazal-like 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00798"
FT DOMAIN 176..229
FT /note="Kazal-like 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00798"
FT DOMAIN 263..303
FT /note="EGF-like"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT REGION 139..161
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 351..372
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 357..372
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 55
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 91..121
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00798"
FT DISULFID 95..114
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00798"
FT DISULFID 103..135
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00798"
FT DISULFID 182..213
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00798"
FT DISULFID 186..206
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00798"
FT DISULFID 195..227
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00798"
FT DISULFID 267..280
FT /evidence="ECO:0000250"
FT DISULFID 275..291
FT /evidence="ECO:0000250"
FT DISULFID 293..302
FT /evidence="ECO:0000250"
FT VAR_SEQ 146
FT /note="G -> GA (in isoform 2 and isoform 3)"
FT /evidence="ECO:0000303|PubMed:11025219,
FT ECO:0000303|PubMed:16141072"
FT /id="VSP_024960"
FT VAR_SEQ 251..252
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_024961"
FT CONFLICT 235
FT /note="L -> S (in Ref. 4; CAB90827)"
FT /evidence="ECO:0000305"
FT CONFLICT 241
FT /note="D -> P (in Ref. 4; CAB90827)"
FT /evidence="ECO:0000305"
FT CONFLICT 244
FT /note="Q -> L (in Ref. 4; CAB90827)"
FT /evidence="ECO:0000305"
FT CONFLICT 370
FT /note="R -> K (in Ref. 4; CAB90827)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 372 AA; 40114 MW; BB3DA6710B78A530 CRC64;
MGAQAPLRLP AAPPLAVCGY TSVLLLFAFC LPGSRASNQP AGGGGDCPGG RGKSNCSELN
LRESDIRVCD ESSCKYGGVC KEDGDGLKCA CQFQCHTNYI PVCGSNGDTY QNECFLRRAA
CKHQKDITVV ARGPCYSDNG SGSGEGEEEG SGAGAHRKHS KCGPCKYKAE CDEDAENVGC
VCNIDCSGYS FNPVCASDGS SYNNPCFVRE ASCIKQEQID IRHLGHCTDT DDVSLLGKKD
DGLQYRPDVK DAGDEREDVY IGSHMPCPEN LNGYCIHGKC EFIYSTQKAS CRCESGYTGQ
HCEKTDFSIL YVVPSRQKLT HVLIAAIIGA VQIAIIVAIV MCITRKCPKN NRGRRQKQNL
GHFTSDTSSR MV
