ID   TEFM_BOVIN              Reviewed;         356 AA.
AC   A6QPR9;
DT   22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   22-JUL-2008, sequence version 2.
DT   25-MAY-2022, entry version 54.
DE   RecName: Full=Transcription elongation factor, mitochondrial;
DE   Flags: Precursor;
GN   Name=TEFM;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Thymus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Transcription elongation factor which increases mitochondrial
CC       RNA polymerase processivity. Regulates transcription of the
CC       mitochondrial genome, including genes important for the oxidative
CC       phosphorylation machinery (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with POLRMT. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000250}. Mitochondrion
CC       matrix, mitochondrion nucleoid {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TEFM family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAI49453.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; BC149452; AAI49453.1; ALT_INIT; mRNA.
DR   AlphaFoldDB; A6QPR9; -.
DR   SMR; A6QPR9; -.
DR   STRING; 9913.ENSBTAP00000024467; -.
DR   PaxDb; A6QPR9; -.
DR   PRIDE; A6QPR9; -.
DR   eggNOG; ENOG502QPVB; Eukaryota.
DR   InParanoid; A6QPR9; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005759; C:mitochondrial matrix; ISS:UniProtKB.
DR   GO; GO:0042645; C:mitochondrial nucleoid; ISS:UniProtKB.
DR   GO; GO:1990904; C:ribonucleoprotein complex; ISS:UniProtKB.
DR   GO; GO:0030337; F:DNA polymerase processivity factor activity; ISS:UniProtKB.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0006390; P:mitochondrial transcription; ISS:UniProtKB.
DR   GO; GO:0006119; P:oxidative phosphorylation; ISS:UniProtKB.
DR   GO; GO:0006392; P:transcription elongation from mitochondrial promoter; IEA:InterPro.
DR   Gene3D; 3.30.420.10; -; 1.
DR   InterPro; IPR036397; RNaseH_sf.
DR   InterPro; IPR010994; RuvA_2-like.
DR   InterPro; IPR039150; TEFM.
DR   PANTHER; PTHR21053; PTHR21053; 1.
DR   SUPFAM; SSF47781; SSF47781; 1.
PE   2: Evidence at transcript level;
KW   Mitochondrion; Mitochondrion nucleoid; Reference proteome; Transcription;
KW   Transcription regulation; Transit peptide.
FT   TRANSIT         1..35
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000255"
FT   CHAIN           36..356
FT                   /note="Transcription elongation factor, mitochondrial"
FT                   /id="PRO_0000406328"
SQ   SEQUENCE   356 AA;  40608 MW;  6C78299CD4975BC5 CRC64;
     MTVPSLLLAG GRWRCFPLPL ASSLFQALHN SCCRKESTAP KKIIPHIDFS DETAKESGKT
     LDKLFSSEQQ ASILHVLNTA SNKELEAFKL LRGKKSFNIV EHRKKFGPFQ NLESLMNVPL
     FQYKITIQVC NSILNPETGG KKKKLQESRL LRKLIKPEIG RERVKAVNSI VSIVSGTRRI
     AWAHLDRKLA VLDWQQTEYC QLMKGSYLSS VYLEEISSII SKMPKADFYV LEKAGPSFQN
     PSLFPVLLHF HMTEAMLYAL LNTTFAQDGH HQVLSMNRNA VGKHFELMIG DTRTSGKEVV
     KQLLSESVLK DEPRVFFPPE KIVRYRQMFS STEHNRVEEL YDSLLQAIAF YELAVF