ID   TEFM_DANRE              Reviewed;         363 AA.
AC   Q0P4D6; B0R1D7;
DT   22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   22-JUL-2008, sequence version 2.
DT   03-AUG-2022, entry version 81.
DE   RecName: Full=Transcription elongation factor, mitochondrial;
DE   Flags: Precursor;
GN   Name=tefm; ORFNames=si:dkey-10p5.4, zgc:153083;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen;
RX   PubMed=23594743; DOI=10.1038/nature12111;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA   Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA   Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA   White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA   Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA   Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA   Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA   Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA   Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA   Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA   Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA   Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA   Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA   McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA   Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA   Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA   Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA   Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA   Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA   Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA   Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA   Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA   Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA   Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA   Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA   Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA   de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA   Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the human
RT   genome.";
RL   Nature 496:498-503(2013).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Ovary;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Transcription elongation factor which increases mitochondrial
CC       RNA polymerase processivity. Regulates transcription of the
CC       mitochondrial genome, including genes important for the oxidative
CC       phosphorylation machinery (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000250}. Mitochondrion
CC       matrix, mitochondrion nucleoid {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TEFM family. {ECO:0000305}.
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DR   EMBL; AL954746; CAQ15135.1; -; Genomic_DNA.
DR   EMBL; BC122136; AAI22137.1; -; mRNA.
DR   RefSeq; NP_001073495.1; NM_001080026.1.
DR   AlphaFoldDB; Q0P4D6; -.
DR   SMR; Q0P4D6; -.
DR   STRING; 7955.ENSDARP00000106828; -.
DR   PaxDb; Q0P4D6; -.
DR   Ensembl; ENSDART00000168636; ENSDARP00000141794; ENSDARG00000100548.
DR   Ensembl; ENSDART00000180084; ENSDARP00000150041; ENSDARG00000114872.
DR   GeneID; 566236; -.
DR   KEGG; dre:566236; -.
DR   CTD; 79736; -.
DR   ZFIN; ZDB-GENE-060825-345; tefm.
DR   eggNOG; ENOG502QPVB; Eukaryota.
DR   GeneTree; ENSGT00390000010581; -.
DR   HOGENOM; CLU_066790_0_0_1; -.
DR   InParanoid; Q0P4D6; -.
DR   OMA; ESPQMAQ; -.
DR   OrthoDB; 1096937at2759; -.
DR   PhylomeDB; Q0P4D6; -.
DR   TreeFam; TF325413; -.
DR   PRO; PR:Q0P4D6; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 6.
DR   Bgee; ENSDARG00000100548; Expressed in liver and 22 other tissues.
DR   GO; GO:0005759; C:mitochondrial matrix; ISS:UniProtKB.
DR   GO; GO:0042645; C:mitochondrial nucleoid; ISS:UniProtKB.
DR   GO; GO:1990904; C:ribonucleoprotein complex; ISS:UniProtKB.
DR   GO; GO:0030337; F:DNA polymerase processivity factor activity; ISS:UniProtKB.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0006390; P:mitochondrial transcription; ISS:UniProtKB.
DR   GO; GO:0006119; P:oxidative phosphorylation; ISS:UniProtKB.
DR   GO; GO:0006392; P:transcription elongation from mitochondrial promoter; IEA:InterPro.
DR   Gene3D; 3.30.420.10; -; 1.
DR   InterPro; IPR036397; RNaseH_sf.
DR   InterPro; IPR010994; RuvA_2-like.
DR   InterPro; IPR039150; TEFM.
DR   PANTHER; PTHR21053; PTHR21053; 1.
DR   SUPFAM; SSF47781; SSF47781; 1.
PE   2: Evidence at transcript level;
KW   Mitochondrion; Mitochondrion nucleoid; Reference proteome; Transcription;
KW   Transcription regulation; Transit peptide.
FT   TRANSIT         1..23
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000255"
FT   CHAIN           24..363
FT                   /note="Transcription elongation factor, mitochondrial"
FT                   /id="PRO_0000406332"
FT   CONFLICT        60
FT                   /note="P -> S (in Ref. 2; AAI22137)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        69
FT                   /note="A -> P (in Ref. 2; AAI22137)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        73
FT                   /note="C -> R (in Ref. 2; AAI22137)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        85
FT                   /note="R -> C (in Ref. 2; AAI22137)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        136
FT                   /note="I -> V (in Ref. 2; AAI22137)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   363 AA;  41156 MW;  16A0669CD41FDA33 CRC64;
     MWIVKGILSS VVLKGHYSLF SRPPPSSLPD YALRFLHFTC CRSSKIMFSE FDSSNASISP
     ELRQENAKAL DSCYTEEQRA VILQRLNTAT ESELEQVKLL RGRKSVNIVK YRTRHGPFSS
     LESVINVPLL KYKSAIMVFD SILNPDNKRK RNKGKVHLAK FIKPDVNRAH LEDASSIISI
     VCGTNKIAWA HMDRARTVLD WQQAECQSFM KGTYLASDYL EDISSVISSF PAADFFLVEK
     PSISPQNTSL FPVMVHLRTV EAMLFALLSQ AREPGSPPKV LNMMRISVGR HFDLMVGDCR
     TSGAETLRKM MTDSVMKRDP RVLFPHDLVL KHRNSFQMSS RNKGEEMCDA LLQAVAFFEL
     LQE