ID   TEFM_RAT                Reviewed;         365 AA.
AC   Q4KM51;
DT   22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   02-AUG-2005, sequence version 1.
DT   25-MAY-2022, entry version 93.
DE   RecName: Full=Transcription elongation factor, mitochondrial;
DE   Flags: Precursor;
GN   Name=Tefm;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Spleen;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Transcription elongation factor which increases mitochondrial
CC       RNA polymerase processivity. Regulates transcription of the
CC       mitochondrial genome, including genes important for the oxidative
CC       phosphorylation machinery (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with POLRMT. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000250}. Mitochondrion
CC       matrix, mitochondrion nucleoid {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TEFM family. {ECO:0000305}.
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DR   EMBL; BC098792; AAH98792.1; -; mRNA.
DR   RefSeq; NP_001020797.1; NM_001025626.1.
DR   AlphaFoldDB; Q4KM51; -.
DR   SMR; Q4KM51; -.
DR   STRING; 10116.ENSRNOP00000005325; -.
DR   PaxDb; Q4KM51; -.
DR   PRIDE; Q4KM51; -.
DR   GeneID; 287554; -.
DR   KEGG; rno:287554; -.
DR   CTD; 79736; -.
DR   RGD; 1306595; Tefm.
DR   eggNOG; ENOG502QPVB; Eukaryota.
DR   InParanoid; Q4KM51; -.
DR   OrthoDB; 1096937at2759; -.
DR   PhylomeDB; Q4KM51; -.
DR   TreeFam; TF325413; -.
DR   PRO; PR:Q4KM51; -.
DR   Proteomes; UP000002494; Unplaced.
DR   GO; GO:0005759; C:mitochondrial matrix; ISS:UniProtKB.
DR   GO; GO:0042645; C:mitochondrial nucleoid; ISS:UniProtKB.
DR   GO; GO:1990904; C:ribonucleoprotein complex; ISS:UniProtKB.
DR   GO; GO:0030337; F:DNA polymerase processivity factor activity; ISS:UniProtKB.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0006390; P:mitochondrial transcription; ISS:UniProtKB.
DR   GO; GO:0006119; P:oxidative phosphorylation; ISS:UniProtKB.
DR   GO; GO:0006392; P:transcription elongation from mitochondrial promoter; IEA:InterPro.
DR   Gene3D; 3.30.420.10; -; 1.
DR   InterPro; IPR036397; RNaseH_sf.
DR   InterPro; IPR010994; RuvA_2-like.
DR   InterPro; IPR039150; TEFM.
DR   PANTHER; PTHR21053; PTHR21053; 1.
DR   SUPFAM; SSF47781; SSF47781; 1.
PE   2: Evidence at transcript level;
KW   Mitochondrion; Mitochondrion nucleoid; Reference proteome; Transcription;
KW   Transcription regulation; Transit peptide.
FT   TRANSIT         1..40
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000255"
FT   CHAIN           41..365
FT                   /note="Transcription elongation factor, mitochondrial"
FT                   /id="PRO_0000406331"
SQ   SEQUENCE   365 AA;  41538 MW;  458F330F41FB7769 CRC64;
     MAWRANLACL IKAGGRTRWF PLPEYLSMSP VLHNTCSRRK STAPEKLAAS VAACDTNGKE
     PGTALGRLYS PEQQASILHV LNTASDKELE AFRLLRGRKS VNIVEHRKKF GPFQSLESLI
     GVPLIQYKTA VEVCNSILCP ENRRRKKSQE KWVLRKFIKP GVEKERLKAV NSIVSIVFGT
     RRIAWAHLDR KPTVLDWQQA ECWKLTNKTY PSSFYLEEIS SVVSKIPKAD LYILEKSGLS
     IQNTSLFPIL LHFLITEAML YALLNKTFAK DGQHRVLSIN RNAVGKHFDL MIGDTRTSGR
     ELVKQFLSES VLKEQPRVFF PRELAVQYRQ KIVKSSHRIE ELYDSLLQAV AFYELVFGSG
     SELKC