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TEF_DROER
ID   TEF_DROER               Reviewed;         658 AA.
AC   B3NP26;
DT   16-JUN-2009, integrated into UniProtKB/Swiss-Prot.
DT   02-SEP-2008, sequence version 1.
DT   25-MAY-2022, entry version 51.
DE   RecName: Full=Protein teflon {ECO:0000250|UniProtKB:Q7K4M4};
GN   Name=tef {ECO:0000250|UniProtKB:Q7K4M4}; ORFNames=GG22222;
OS   Drosophila erecta (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7220;
RN   [1] {ECO:0000312|EMBL:EDV55665.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tucson 14021-0224.01 {ECO:0000312|EMBL:EDV55665.1};
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- FUNCTION: Specifically required in males for proper segregation of
CC       autosomal bivalents at meiosis I. Expression is required in the male
CC       germ line prior to spermatocyte stage S4. May have a role as a bridging
CC       molecule maintaining adhesion to hold autosome bivalents together via
CC       heterochromatic connections (By similarity).
CC       {ECO:0000250|UniProtKB:Q7K4M4}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q7K4M4}.
CC       Chromosome {ECO:0000250}. Note=Male meiotic chromosomes.
CC       {ECO:0000250|UniProtKB:Q7K4M4}.
CC   -!- MISCELLANEOUS: Drosophilid specific gene duplication generates rgr and
CC       tef. Teflon has a function unique to Drosophilids.
CC       {ECO:0000250|UniProtKB:Q7K4M4}.
CC   -!- SIMILARITY: Belongs to the Teflon family. {ECO:0000305}.
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DR   EMBL; CH954179; EDV55665.1; -; Genomic_DNA.
DR   RefSeq; XP_001975265.1; XM_001975229.2.
DR   AlphaFoldDB; B3NP26; -.
DR   PRIDE; B3NP26; -.
DR   EnsemblMetazoa; FBtr0142276; FBpp0140768; FBgn0114395.
DR   GeneID; 6548233; -.
DR   KEGG; der:6548233; -.
DR   eggNOG; ENOG502T9CV; Eukaryota.
DR   HOGENOM; CLU_014432_0_0_1; -.
DR   OMA; TKEHNVY; -.
DR   OrthoDB; 602441at2759; -.
DR   PhylomeDB; B3NP26; -.
DR   Proteomes; UP000008711; Unassembled WGS sequence.
DR   GO; GO:0030849; C:autosome; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0051308; P:male meiosis chromosome separation; ISS:UniProtKB.
DR   GO; GO:0007141; P:male meiosis I; IEA:EnsemblMetazoa.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   SMART; SM00355; ZnF_C2H2; 3.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 2.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 1.
PE   3: Inferred from homology;
KW   Cell cycle; Chromosome; Chromosome partition; Meiosis; Metal-binding;
KW   Nucleus; Repeat; Zinc; Zinc-finger.
FT   CHAIN           1..658
FT                   /note="Protein teflon"
FT                   /id="PRO_0000377407"
FT   ZN_FING         33..56
FT                   /note="C2H2-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         608..630
FT                   /note="C2H2-type 2; degenerate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         634..657
FT                   /note="C2H2-type 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   REGION          78..127
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          151..175
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        101..121
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   658 AA;  74390 MW;  EC6DEBCE49DE9DF0 CRC64;
     MSAFLDKLSG SQCVSLEKCG DVVVSTNDCM IALYCHFCRD LFTQLPEFLR HLQGAHSDVL
     HFTKEHNVYS VEELMSGEQD DAQEDAHSAG HNSSSGDSRI PAKSEDSRAI DASEDNSDNS
     PVKSEQKGMQ NEINLLAEVT NILLQSKERE HINNESKPEN GGFNGPCKKA SSESNSLRIC
     DLKSHTIART SRKRMSMLKN RILRVIDSDV SAKREMKPSE PNYILPITET IQEDNIPKIC
     FETQPKPIPS SSNLSVRKSS LSEPNVSLAC TNYAAKKTTL TIPKLLNCTP KSNLPCQQSQ
     VYSDSNGRSE TYHISKATSQ GSKEMESFPV KITQIDVLPP LILPETSTTP NQKERVNALV
     ENNTVNLYTA QNLPKEKPKK FFKKRGELWM KSEDSPSKSV KITKYRGNPI IVKRVQTSSA
     KSSPCKTQIR SNDKTKCFAS EFNSTKIRKL KMENSIALKK EDPCSNKSIR LSKMATISSC
     EILKVVGLPA ITDQKLEDTL LLDELETMRK KADQFSKIYK KYDSIWNYRK IFPPGKPEFI
     SQKMFALTRE VNETMGCNLA NSAIKSIINQ ISVWHYNIYT KCIVLDTISE TARHTLKLFS
     FLPVSFAYFC KCCDDIFTLN EDYTRHLVSQ QARYQCTKCI KAFKYRGHFE KHLQNVHP
 
 
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