TEF_DROER
ID TEF_DROER Reviewed; 658 AA.
AC B3NP26;
DT 16-JUN-2009, integrated into UniProtKB/Swiss-Prot.
DT 02-SEP-2008, sequence version 1.
DT 25-MAY-2022, entry version 51.
DE RecName: Full=Protein teflon {ECO:0000250|UniProtKB:Q7K4M4};
GN Name=tef {ECO:0000250|UniProtKB:Q7K4M4}; ORFNames=GG22222;
OS Drosophila erecta (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7220;
RN [1] {ECO:0000312|EMBL:EDV55665.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tucson 14021-0224.01 {ECO:0000312|EMBL:EDV55665.1};
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
CC -!- FUNCTION: Specifically required in males for proper segregation of
CC autosomal bivalents at meiosis I. Expression is required in the male
CC germ line prior to spermatocyte stage S4. May have a role as a bridging
CC molecule maintaining adhesion to hold autosome bivalents together via
CC heterochromatic connections (By similarity).
CC {ECO:0000250|UniProtKB:Q7K4M4}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q7K4M4}.
CC Chromosome {ECO:0000250}. Note=Male meiotic chromosomes.
CC {ECO:0000250|UniProtKB:Q7K4M4}.
CC -!- MISCELLANEOUS: Drosophilid specific gene duplication generates rgr and
CC tef. Teflon has a function unique to Drosophilids.
CC {ECO:0000250|UniProtKB:Q7K4M4}.
CC -!- SIMILARITY: Belongs to the Teflon family. {ECO:0000305}.
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DR EMBL; CH954179; EDV55665.1; -; Genomic_DNA.
DR RefSeq; XP_001975265.1; XM_001975229.2.
DR AlphaFoldDB; B3NP26; -.
DR PRIDE; B3NP26; -.
DR EnsemblMetazoa; FBtr0142276; FBpp0140768; FBgn0114395.
DR GeneID; 6548233; -.
DR KEGG; der:6548233; -.
DR eggNOG; ENOG502T9CV; Eukaryota.
DR HOGENOM; CLU_014432_0_0_1; -.
DR OMA; TKEHNVY; -.
DR OrthoDB; 602441at2759; -.
DR PhylomeDB; B3NP26; -.
DR Proteomes; UP000008711; Unassembled WGS sequence.
DR GO; GO:0030849; C:autosome; ISS:UniProtKB.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0051308; P:male meiosis chromosome separation; ISS:UniProtKB.
DR GO; GO:0007141; P:male meiosis I; IEA:EnsemblMetazoa.
DR InterPro; IPR013087; Znf_C2H2_type.
DR SMART; SM00355; ZnF_C2H2; 3.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 2.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 1.
PE 3: Inferred from homology;
KW Cell cycle; Chromosome; Chromosome partition; Meiosis; Metal-binding;
KW Nucleus; Repeat; Zinc; Zinc-finger.
FT CHAIN 1..658
FT /note="Protein teflon"
FT /id="PRO_0000377407"
FT ZN_FING 33..56
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 608..630
FT /note="C2H2-type 2; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 634..657
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 78..127
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 151..175
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 101..121
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 658 AA; 74390 MW; EC6DEBCE49DE9DF0 CRC64;
MSAFLDKLSG SQCVSLEKCG DVVVSTNDCM IALYCHFCRD LFTQLPEFLR HLQGAHSDVL
HFTKEHNVYS VEELMSGEQD DAQEDAHSAG HNSSSGDSRI PAKSEDSRAI DASEDNSDNS
PVKSEQKGMQ NEINLLAEVT NILLQSKERE HINNESKPEN GGFNGPCKKA SSESNSLRIC
DLKSHTIART SRKRMSMLKN RILRVIDSDV SAKREMKPSE PNYILPITET IQEDNIPKIC
FETQPKPIPS SSNLSVRKSS LSEPNVSLAC TNYAAKKTTL TIPKLLNCTP KSNLPCQQSQ
VYSDSNGRSE TYHISKATSQ GSKEMESFPV KITQIDVLPP LILPETSTTP NQKERVNALV
ENNTVNLYTA QNLPKEKPKK FFKKRGELWM KSEDSPSKSV KITKYRGNPI IVKRVQTSSA
KSSPCKTQIR SNDKTKCFAS EFNSTKIRKL KMENSIALKK EDPCSNKSIR LSKMATISSC
EILKVVGLPA ITDQKLEDTL LLDELETMRK KADQFSKIYK KYDSIWNYRK IFPPGKPEFI
SQKMFALTRE VNETMGCNLA NSAIKSIINQ ISVWHYNIYT KCIVLDTISE TARHTLKLFS
FLPVSFAYFC KCCDDIFTLN EDYTRHLVSQ QARYQCTKCI KAFKYRGHFE KHLQNVHP