TEF_DROPE
ID TEF_DROPE Reviewed; 703 AA.
AC B4GBA9;
DT 16-JUN-2009, integrated into UniProtKB/Swiss-Prot.
DT 16-JUN-2009, sequence version 2.
DT 25-MAY-2022, entry version 46.
DE RecName: Full=Protein teflon {ECO:0000250|UniProtKB:Q7K4M4};
GN Name=tef {ECO:0000250|UniProtKB:Q7K4M4}; ORFNames=GL10555;
OS Drosophila persimilis (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7234;
RN [1] {ECO:0000312|EMBL:EDW32211.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MSH-3 / Tucson 14011-0111.49;
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
CC -!- FUNCTION: Specifically required in males for proper segregation of
CC autosomal bivalents at meiosis I. Expression is required in the male
CC germ line prior to spermatocyte stage S4. May have a role as a bridging
CC molecule maintaining adhesion to hold autosome bivalents together via
CC heterochromatic connections (By similarity).
CC {ECO:0000250|UniProtKB:Q7K4M4}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q7K4M4}.
CC Chromosome {ECO:0000250}. Note=Male meiotic chromosomes.
CC {ECO:0000250|UniProtKB:Q7K4M4}.
CC -!- MISCELLANEOUS: Drosophilid specific gene duplication generates rgr and
CC tef. Teflon has a function unique to Drosophilids.
CC {ECO:0000250|UniProtKB:Q7K4M4}.
CC -!- SIMILARITY: Belongs to the Teflon family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=EDW32211.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; CH479181; EDW32211.1; ALT_SEQ; Genomic_DNA.
DR RefSeq; XP_002016321.1; XM_002016285.1.
DR AlphaFoldDB; B4GBA9; -.
DR SMR; B4GBA9; -.
DR GeneID; 6590154; -.
DR KEGG; dpe:6590154; -.
DR eggNOG; ENOG502T9CV; Eukaryota.
DR Proteomes; UP000008744; Unassembled WGS sequence.
DR GO; GO:0030849; C:autosome; ISS:UniProtKB.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0051308; P:male meiosis chromosome separation; ISS:UniProtKB.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR SMART; SM00355; ZnF_C2H2; 3.
DR SUPFAM; SSF57667; SSF57667; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 3.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 2.
PE 3: Inferred from homology;
KW Cell cycle; Chromosome; Chromosome partition; Meiosis; Metal-binding;
KW Nucleus; Reference proteome; Repeat; Zinc; Zinc-finger.
FT CHAIN 1..703
FT /note="Protein teflon"
FT /id="PRO_0000377409"
FT ZN_FING 32..55
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 649..672
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 677..700
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 78..111
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 140..161
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 205..239
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 339..434
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 79..95
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 214..239
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 339..354
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 363..397
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 404..432
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 703 AA; 80065 MW; 9603B7408C153BEF CRC64;
MSSFLDILGD GHVNFEKCGD VVVSPKDNMV AMLCHFCKDI FTHLPEFMRH LQWSHSDVLQ
FTKEQNVYRV EELMSLESSE DDVQSQANSC SSGDSGLAGE MEDADGEPGS SECLANNVEI
MNALAAFDVD VDVLNNVSHE QSYSKNPPDS RTEGFRCARK PGRVEKPPSI CDLKSYNITR
HSRKREAIKQ RLSSVKKRIM RSLENDVSKP RLNKLRSKLN NSLSSNISGP PKQSKMPSLL
ENSSVNELPA VLESTNPPSF DSEQPYVVST TIKPSIRPCP SRTAVQTDRN ISHQPVARRS
TVNIERVDIL PPINIKQKMK MSAKDIPFWE SIIISSVASQ QPSELNTTNN AVDQPPKRPE
RRSSLTVISS SPIQAMKPMR RSSMTRENTS PESSRILRSG EVESPAKANK RTKDSFEETS
SSNEKGNAKR SKLEQNRCSM NFSLSASVTE YIRSDLKTSK LDLDSLLRLT EPLESDAFEN
TLVEDQVKNA TKMGSPQKEF TKLQIGVKPE MEALKEDLRL LKTVGLLVLK DSCFEDKLPF
EQSESFRKTA AKFSKIYHTY DTIWSYRKTK TIGVHQRLTE QLNSFTEEVN REIDCHLTTN
EIKRILNLIN SWYAYQIDQR FFRKATLSYS VEHYMFLFHF LPKINPTVYF CECCEEIFPN
EARYKKHVQS VHAVHAFTCS ECGKSFKRLY FYDKHLKTVH LKP