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TEF_DROPE
ID   TEF_DROPE               Reviewed;         703 AA.
AC   B4GBA9;
DT   16-JUN-2009, integrated into UniProtKB/Swiss-Prot.
DT   16-JUN-2009, sequence version 2.
DT   25-MAY-2022, entry version 46.
DE   RecName: Full=Protein teflon {ECO:0000250|UniProtKB:Q7K4M4};
GN   Name=tef {ECO:0000250|UniProtKB:Q7K4M4}; ORFNames=GL10555;
OS   Drosophila persimilis (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7234;
RN   [1] {ECO:0000312|EMBL:EDW32211.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MSH-3 / Tucson 14011-0111.49;
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- FUNCTION: Specifically required in males for proper segregation of
CC       autosomal bivalents at meiosis I. Expression is required in the male
CC       germ line prior to spermatocyte stage S4. May have a role as a bridging
CC       molecule maintaining adhesion to hold autosome bivalents together via
CC       heterochromatic connections (By similarity).
CC       {ECO:0000250|UniProtKB:Q7K4M4}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q7K4M4}.
CC       Chromosome {ECO:0000250}. Note=Male meiotic chromosomes.
CC       {ECO:0000250|UniProtKB:Q7K4M4}.
CC   -!- MISCELLANEOUS: Drosophilid specific gene duplication generates rgr and
CC       tef. Teflon has a function unique to Drosophilids.
CC       {ECO:0000250|UniProtKB:Q7K4M4}.
CC   -!- SIMILARITY: Belongs to the Teflon family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EDW32211.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; CH479181; EDW32211.1; ALT_SEQ; Genomic_DNA.
DR   RefSeq; XP_002016321.1; XM_002016285.1.
DR   AlphaFoldDB; B4GBA9; -.
DR   SMR; B4GBA9; -.
DR   GeneID; 6590154; -.
DR   KEGG; dpe:6590154; -.
DR   eggNOG; ENOG502T9CV; Eukaryota.
DR   Proteomes; UP000008744; Unassembled WGS sequence.
DR   GO; GO:0030849; C:autosome; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0051308; P:male meiosis chromosome separation; ISS:UniProtKB.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   SMART; SM00355; ZnF_C2H2; 3.
DR   SUPFAM; SSF57667; SSF57667; 1.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 3.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 2.
PE   3: Inferred from homology;
KW   Cell cycle; Chromosome; Chromosome partition; Meiosis; Metal-binding;
KW   Nucleus; Reference proteome; Repeat; Zinc; Zinc-finger.
FT   CHAIN           1..703
FT                   /note="Protein teflon"
FT                   /id="PRO_0000377409"
FT   ZN_FING         32..55
FT                   /note="C2H2-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         649..672
FT                   /note="C2H2-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         677..700
FT                   /note="C2H2-type 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   REGION          78..111
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          140..161
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          205..239
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          339..434
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        79..95
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        214..239
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        339..354
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        363..397
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        404..432
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   703 AA;  80065 MW;  9603B7408C153BEF CRC64;
     MSSFLDILGD GHVNFEKCGD VVVSPKDNMV AMLCHFCKDI FTHLPEFMRH LQWSHSDVLQ
     FTKEQNVYRV EELMSLESSE DDVQSQANSC SSGDSGLAGE MEDADGEPGS SECLANNVEI
     MNALAAFDVD VDVLNNVSHE QSYSKNPPDS RTEGFRCARK PGRVEKPPSI CDLKSYNITR
     HSRKREAIKQ RLSSVKKRIM RSLENDVSKP RLNKLRSKLN NSLSSNISGP PKQSKMPSLL
     ENSSVNELPA VLESTNPPSF DSEQPYVVST TIKPSIRPCP SRTAVQTDRN ISHQPVARRS
     TVNIERVDIL PPINIKQKMK MSAKDIPFWE SIIISSVASQ QPSELNTTNN AVDQPPKRPE
     RRSSLTVISS SPIQAMKPMR RSSMTRENTS PESSRILRSG EVESPAKANK RTKDSFEETS
     SSNEKGNAKR SKLEQNRCSM NFSLSASVTE YIRSDLKTSK LDLDSLLRLT EPLESDAFEN
     TLVEDQVKNA TKMGSPQKEF TKLQIGVKPE MEALKEDLRL LKTVGLLVLK DSCFEDKLPF
     EQSESFRKTA AKFSKIYHTY DTIWSYRKTK TIGVHQRLTE QLNSFTEEVN REIDCHLTTN
     EIKRILNLIN SWYAYQIDQR FFRKATLSYS VEHYMFLFHF LPKINPTVYF CECCEEIFPN
     EARYKKHVQS VHAVHAFTCS ECGKSFKRLY FYDKHLKTVH LKP
 
 
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