TEF_DROPS
ID TEF_DROPS Reviewed; 703 AA.
AC Q290S5; Q5MBD9;
DT 16-JUN-2009, integrated into UniProtKB/Swiss-Prot.
DT 16-JUN-2009, sequence version 3.
DT 25-MAY-2022, entry version 60.
DE RecName: Full=Protein teflon {ECO:0000250|UniProtKB:Q7K4M4};
GN Name=tef {ECO:0000250|UniProtKB:Q7K4M4}; ORFNames=GA21437;
OS Drosophila pseudoobscura pseudoobscura (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=46245;
RN [1] {ECO:0000312|EMBL:AAW24439.2}
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=MV2-25 / Tucson 14011-0121.94;
RX PubMed=16816414; DOI=10.1534/genetics.106.061556;
RA Arya G.H., Lodico M.J.P., Ahmad O.I., Amin R., Tomkiel J.E.;
RT "Molecular characterization of teflon, a gene required for meiotic autosome
RT segregation in male Drosophila melanogaster.";
RL Genetics 174:125-134(2006).
RN [2] {ECO:0000312|EMBL:EAL25287.2}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MV2-25 / Tucson 14011-0121.94;
RX PubMed=15632085; DOI=10.1101/gr.3059305;
RA Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S.,
RA Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P., Couronne O.,
RA Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J., van Batenburg M.F.,
RA Howells S.L., Scherer S.E., Sodergren E., Matthews B.B., Crosby M.A.,
RA Schroeder A.J., Ortiz-Barrientos D., Rives C.M., Metzker M.L., Muzny D.M.,
RA Scott G., Steffen D., Wheeler D.A., Worley K.C., Havlak P., Durbin K.J.,
RA Egan A., Gill R., Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y.,
RA Waldron L., Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A.F.,
RA Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W.M.,
RA Weinstock G.M., Gibbs R.A.;
RT "Comparative genome sequencing of Drosophila pseudoobscura: chromosomal,
RT gene, and cis-element evolution.";
RL Genome Res. 15:1-18(2005).
CC -!- FUNCTION: Specifically required in males for proper segregation of
CC autosomal bivalents at meiosis I. Expression is required in the male
CC germ line prior to spermatocyte stage S4. May have a role as a bridging
CC molecule maintaining adhesion to hold autosome bivalents together via
CC heterochromatic connections (By similarity).
CC {ECO:0000250|UniProtKB:Q7K4M4}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q7K4M4}.
CC Chromosome {ECO:0000250}. Note=Male meiotic chromosomes.
CC {ECO:0000250|UniProtKB:Q7K4M4}.
CC -!- MISCELLANEOUS: Drosophilid specific gene duplication generates rgr and
CC tef. Teflon has a function unique to Drosophilids.
CC {ECO:0000250|UniProtKB:Q7K4M4}.
CC -!- SIMILARITY: Belongs to the Teflon family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=EAL25287.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AY840221; AAW24439.2; -; mRNA.
DR EMBL; CM000071; EAL25287.2; ALT_SEQ; Genomic_DNA.
DR AlphaFoldDB; Q290S5; -.
DR STRING; 46245.Q290S5; -.
DR eggNOG; ENOG502T9CV; Eukaryota.
DR InParanoid; Q290S5; -.
DR Proteomes; UP000001819; Genome assembly.
DR GO; GO:0030849; C:autosome; ISS:UniProtKB.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0051308; P:male meiosis chromosome separation; ISS:UniProtKB.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR SMART; SM00355; ZnF_C2H2; 3.
DR SUPFAM; SSF57667; SSF57667; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 3.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 2.
PE 2: Evidence at transcript level;
KW Cell cycle; Chromosome; Chromosome partition; Meiosis; Metal-binding;
KW Nucleus; Reference proteome; Repeat; Zinc; Zinc-finger.
FT CHAIN 1..703
FT /note="Protein teflon"
FT /id="PRO_0000377410"
FT ZN_FING 32..55
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 649..672
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 677..700
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 78..111
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 138..161
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 339..434
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 79..95
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 339..354
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 363..397
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 404..432
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 703 AA; 80060 MW; 4978F0DA7ACFF480 CRC64;
MSSFLDILGD GHVNFEKCGD VVVSPKDNMV AMFCHFCKDI FTHLPEFMRH LQWSHSDVLQ
FTKEQNVYRV EELMSLETSE DDVQSQANSC SSGDSGLAGE MEDADGEPGS SECLANNLEI
MNALAAFDVD VDGLNNVSHE QSYSKTPPDS RTEGFRCARK PGRVEKPPSI CDLKSYNITR
HSRKREAIKQ RLSSVKKRIM RSLENDVISP RLNKLRSKLN NSLSSNISGP PKQSKMPSLL
ENSSVNELPA VLESTNPPNF DSEQPYVVST TIKPSIRPCP SRTAVKTDRN ISHQPVARRS
TVNIERVDIL PPINIKQKMK MSAKDIPFWE SIIISSVASQ QPSELNTTNN AVDQPPKRPE
RRSSLTVISS SPIQAMKPMR RSSMTRENTS PESSGILRSG EVESPAKANK RTKDSFEETS
SSNEKGNAKR SKLEQNRCSM NFSLSASVTE YIRSDLKTSK LDLDSILRLA EPLESDYFKN
TIVEDQVKNA TKMGSPQKEF TKLQIGVKPE MEALKEDLRL LKTVGLLVLK DSCFEDKLPF
EQSESFRKTA AKFSKIYHTY DTIWSYRKTK TIGVHQRLTE QLNSFTEEVN REIDCHLTTN
EIKRILNLIN SWYAYQIDQR FFRKATLSYS VEHYMFLFHF LPKINPTVYF CECCEEIFPN
EARYKKHVQS VHAVHAFTCS ECGKSFKRLY FYEKHLKTVH LKP
