ID   TEF_DROSE               Reviewed;         656 AA.
AC   B4HMH2;
DT   16-JUN-2009, integrated into UniProtKB/Swiss-Prot.
DT   23-SEP-2008, sequence version 1.
DT   25-MAY-2022, entry version 49.
DE   RecName: Full=Protein teflon {ECO:0000250|UniProtKB:Q7K4M4};
GN   Name=tef {ECO:0000250|UniProtKB:Q7K4M4}; ORFNames=GM20010;
OS   Drosophila sechellia (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7238;
RN   [1] {ECO:0000312|EMBL:EDW48240.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Rob3c / Tucson 14021-0248.25 {ECO:0000312|EMBL:EDW48240.1};
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- FUNCTION: Specifically required in males for proper segregation of
CC       autosomal bivalents at meiosis I. Expression is required in the male
CC       germ line prior to spermatocyte stage S4. May have a role as a bridging
CC       molecule maintaining adhesion to hold autosome bivalents together via
CC       heterochromatic connections (By similarity).
CC       {ECO:0000250|UniProtKB:Q7K4M4}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q7K4M4}.
CC       Chromosome {ECO:0000250}. Note=Male meiotic chromosomes.
CC       {ECO:0000250|UniProtKB:Q7K4M4}.
CC   -!- MISCELLANEOUS: Drosophilid specific gene duplication generates rgr and
CC       tef. Teflon has a function unique to Drosophilids.
CC       {ECO:0000250|UniProtKB:Q7K4M4}.
CC   -!- SIMILARITY: Belongs to the Teflon family. {ECO:0000305}.
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DR   EMBL; CH480816; EDW48240.1; -; Genomic_DNA.
DR   RefSeq; XP_002034227.1; XM_002034191.1.
DR   AlphaFoldDB; B4HMH2; -.
DR   STRING; 7238.B4HMH2; -.
DR   EnsemblMetazoa; FBtr0202995; FBpp0201487; FBgn0174895.
DR   GeneID; 6609544; -.
DR   KEGG; dse:6609544; -.
DR   HOGENOM; CLU_014432_0_0_1; -.
DR   OMA; TKEHNVY; -.
DR   PhylomeDB; B4HMH2; -.
DR   Proteomes; UP000001292; Unassembled WGS sequence.
DR   GO; GO:0030849; C:autosome; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0051308; P:male meiosis chromosome separation; ISS:UniProtKB.
DR   GO; GO:0007141; P:male meiosis I; IEA:EnsemblMetazoa.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   SMART; SM00355; ZnF_C2H2; 3.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 3.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 1.
PE   3: Inferred from homology;
KW   Cell cycle; Chromosome; Chromosome partition; Meiosis; Metal-binding;
KW   Nucleus; Reference proteome; Repeat; Zinc; Zinc-finger.
FT   CHAIN           1..656
FT                   /note="Protein teflon"
FT                   /id="PRO_0000377411"
FT   ZN_FING         33..56
FT                   /note="C2H2-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         606..628
FT                   /note="C2H2-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         632..655
FT                   /note="C2H2-type 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   REGION          80..131
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        88..107
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        114..131
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   656 AA;  74371 MW;  3FD2FDEBC40F8138 CRC64;
     MSKFLDMLSG SQCVSLEKCG DVVVSTNDCM IALYCHFCRD LFTQLPEFLR HLQSNHSDVL
     HFTKEHNVYS VEELLSGEQD KAHEDAQSAG HNSSSGDSRS LMNSEDSRAI DGSEENSDNS
     PVKPEQIGKQ NEINLLAEVT NILLQTNDKE RINDELKPES GVFKGARKKA NNESSSLKIC
     DLKSHTIART SRKRMSLVKN HILRVLDRDL SAKLEMKPLE PNSKLPITEP IQEDNIPGTC
     FQTPPKPIPS LSQLSVRKSS LTEANHICTK YATNKTAPTV PKLLNNVPKS ILTSQQAQVN
     SDSSEINETY HISEAGSQVT KTTKSFPVKI NQIEILQPLK LPKTLITPIN EEGVSDQMEN
     STKNINNAQR KKENPKKFFK KPSELGIKTQ GSPNKFLNII KSKANPIIVN RVQTTSAKAS
     TNKIQIRFND KTKGFASEFN STKIRKLKME NCVDLKTEDP CDNTNMRLNK MATIGSCEIL
     KAVGLPAITD NAIEAIMLLP DELETMRKKA DQFTKIYRKY DSIWNYRKIF PPAKPDFISQ
     KIFALTREVN KTMLCNLANS DIKGIINQIS VWHYNIYTQY IDLDTISEIA RYTLKVFSFL
     PVSFAYFCKC CDDIFILKKE YLKHLISHQV RFQCTKCIKV FKYKGYYEKH LRNAHP