TEF_DROSI
ID TEF_DROSI Reviewed; 658 AA.
AC B4QIJ9; B6UYC0; B6UYC1; B6UYC3; B6UYC4;
DT 16-JUN-2009, integrated into UniProtKB/Swiss-Prot.
DT 23-SEP-2008, sequence version 1.
DT 03-AUG-2022, entry version 54.
DE RecName: Full=Protein teflon {ECO:0000250|UniProtKB:Q7K4M4, ECO:0000312|EMBL:ACI96577.1};
GN Name=tef {ECO:0000250|UniProtKB:Q7K4M4}; ORFNames=GD25499;
OS Drosophila simulans (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7240;
RN [1] {ECO:0000312|EMBL:EDX07446.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
RN [2] {ECO:0000305, ECO:0000312|EMBL:ACI96577.1}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 74-438, AND VARIANTS MET-135; DEL-151;
RP VAL-163; ARG-165; VAL-167; LEU-207; VAL-212; ASN-223; THR-364; PHE-381 AND
RP GLN-392.
RC STRAIN=C1674 {ECO:0000312|EMBL:ACI96582.1},
RC Md106 {ECO:0000312|EMBL:ACI96579.1}, Md199 {ECO:0000312|EMBL:ACI96580.1},
RC NewC {ECO:0000312|EMBL:ACI96577.1}, Sim {ECO:0000312|EMBL:ACI96576.1}, and
RC W501 {ECO:0000312|EMBL:ACI96581.1};
RX PubMed=18984573; DOI=10.1534/genetics.108.093807;
RA Anderson J.A., Gilliland W.D., Langley C.H.;
RT "Molecular population genetics and evolution of Drosophila meiosis genes.";
RL Genetics 181:177-185(2009).
CC -!- FUNCTION: Specifically required in males for proper segregation of
CC autosomal bivalents at meiosis I. Expression is required in the male
CC germ line prior to spermatocyte stage S4. May have a role as a bridging
CC molecule maintaining adhesion to hold autosome bivalents together via
CC heterochromatic connections (By similarity).
CC {ECO:0000250|UniProtKB:Q7K4M4}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q7K4M4}.
CC Chromosome {ECO:0000250}. Note=Male meiotic chromosomes.
CC {ECO:0000250|UniProtKB:Q7K4M4}.
CC -!- MISCELLANEOUS: Drosophilid specific gene duplication generates rgr and
CC tef. Teflon has a function unique to Drosophilids.
CC {ECO:0000250|UniProtKB:Q7K4M4}.
CC -!- SIMILARITY: Belongs to the Teflon family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CM000362; EDX07446.1; -; Genomic_DNA.
DR EMBL; FJ219518; ACI96576.1; -; Genomic_DNA.
DR EMBL; FJ219519; ACI96577.1; -; Genomic_DNA.
DR EMBL; FJ219521; ACI96579.1; -; Genomic_DNA.
DR EMBL; FJ219522; ACI96580.1; -; Genomic_DNA.
DR EMBL; FJ219523; ACI96581.1; -; Genomic_DNA.
DR EMBL; FJ219524; ACI96582.1; -; Genomic_DNA.
DR AlphaFoldDB; B4QIJ9; -.
DR STRING; 7240.B4QIJ9; -.
DR HOGENOM; CLU_014432_0_0_1; -.
DR OMA; TKEHNVY; -.
DR PhylomeDB; B4QIJ9; -.
DR Proteomes; UP000000304; Chromosome 2r.
DR GO; GO:0030849; C:autosome; ISS:UniProtKB.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0051308; P:male meiosis chromosome separation; ISS:UniProtKB.
DR GO; GO:0007141; P:male meiosis I; IEA:EnsemblMetazoa.
DR InterPro; IPR013087; Znf_C2H2_type.
DR SMART; SM00355; ZnF_C2H2; 3.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 3.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 1.
PE 3: Inferred from homology;
KW Cell cycle; Chromosome; Chromosome partition; Meiosis; Metal-binding;
KW Nucleus; Reference proteome; Repeat; Zinc; Zinc-finger.
FT CHAIN 1..658
FT /note="Protein teflon"
FT /id="PRO_0000377412"
FT ZN_FING 33..56
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 608..630
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 634..657
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 80..131
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 88..107
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 114..131
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 135
FT /note="L -> M (in strain: Md199)"
FT /evidence="ECO:0000269|PubMed:18984573"
FT VARIANT 151
FT /note="Missing (in strain: Md106, Md199 and NewC)"
FT /evidence="ECO:0000269|PubMed:18984573"
FT VARIANT 163
FT /note="E -> V (in strain: Md106, Md199 and NewC)"
FT /evidence="ECO:0000269|PubMed:18984573"
FT VARIANT 165
FT /note="K -> R (in strain: Md199, NewC)"
FT /evidence="ECO:0000269|PubMed:18984573"
FT VARIANT 167
FT /note="A -> V (in strain: Md199, NewC)"
FT /evidence="ECO:0000269|PubMed:18984573"
FT VARIANT 207
FT /note="F -> L (in strain: C1674, Md106, Md199, NewC, Sim
FT and W501)"
FT /evidence="ECO:0000269|PubMed:18984573"
FT VARIANT 212
FT /note="I -> V (in strain: Md199)"
FT /evidence="ECO:0000269|PubMed:18984573"
FT VARIANT 223
FT /note="D -> N (in strain: Md199)"
FT /evidence="ECO:0000269|PubMed:18984573"
FT VARIANT 364
FT /note="K -> T (in strain: Md199)"
FT /evidence="ECO:0000269|PubMed:18984573"
FT VARIANT 381
FT /note="L -> F (in strain: Md106, Md199 and NewC)"
FT /evidence="ECO:0000269|PubMed:18984573"
FT VARIANT 392
FT /note="K -> Q (in strain: NewC)"
FT /evidence="ECO:0000269|PubMed:18984573"
SQ SEQUENCE 658 AA; 74875 MW; C8F2D049FA9FC0AE CRC64;
MSKFLDMLSG SQCVSLEKCG DVVVSTNDCM IALYCHFCRD LFTQLPEFLR HLQSNHSDVL
HFTKEHNVYS VEELLSGEQD KAHEDAQSAG HNSSSGDSRS LMNSEDSRAI DGSEENSDNS
PVKPEQIGKQ NEINLLAEVT NILLQTNDKE ERINDELKPE SGEFKGARKK ANNESSSLKI
CDLKSHTIAR TSRKRMSLVK NHILRVFDRD LIAKLEMKPL EPDSKLPITE PIQEDNIPGT
CFQTPPKPIP SLSQLSVRKS SLTEANHICT KYDTKKTAPT MPKLLNNVPK SILTSQQAQV
NSDSSEINET YHISEAASQV TKTTKSFPVQ INQIEILQPL KLPKTLITPI NEEGVSDQME
NSTKNINNAQ SLLKENPKKF LKKPSELEIK TKGGPNKFLN VIKSKADPII VKRVQTTSAK
DSTNKIQIRS NDKTKGFASE FNSTKIRKLK MENCVDLKTE DPCDNTNMRL NKMATIGSCE
ILKAVGLPAI TDNAIEAIML LPDELETMRI RADQFTKIYK KYYSIWNYRK IFPPAKPDFI
SQKIFALTRE VNKTMLCNLA NSDIKGIINQ ISVWHYNIYT QYIELDNISE IARYTLKLFS
FLPVSFAYFC KWCDDIFILK KEYLKHLISH QVRFQCTKCI KVFKYKGYYE KHLRNAHP
