ID   TEF_DROYA               Reviewed;         648 AA.
AC   B4P8I0; B6UYB9;
DT   16-JUN-2009, integrated into UniProtKB/Swiss-Prot.
DT   23-SEP-2008, sequence version 1.
DT   03-AUG-2022, entry version 56.
DE   RecName: Full=Protein teflon {ECO:0000250|UniProtKB:Q7K4M4, ECO:0000312|EMBL:ACI96575.1};
GN   Name=tef {ECO:0000250|UniProtKB:Q7K4M4}; ORFNames=GE14219;
OS   Drosophila yakuba (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7245;
RN   [1] {ECO:0000312|EMBL:EDW92197.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tai18E2 / Tucson 14021-0261.01 {ECO:0000312|EMBL:EDW92197.1};
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
RN   [2] {ECO:0000312|EMBL:ACI96575.1}
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 74-429.
RX   PubMed=18984573; DOI=10.1534/genetics.108.093807;
RA   Anderson J.A., Gilliland W.D., Langley C.H.;
RT   "Molecular population genetics and evolution of Drosophila meiosis genes.";
RL   Genetics 181:177-185(2009).
CC   -!- FUNCTION: Specifically required in males for proper segregation of
CC       autosomal bivalents at meiosis I. Expression is required in the male
CC       germ line prior to spermatocyte stage S4. May have a role as a bridging
CC       molecule maintaining adhesion to hold autosome bivalents together via
CC       heterochromatic connections (By similarity).
CC       {ECO:0000250|UniProtKB:Q7K4M4}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q7K4M4}.
CC       Chromosome {ECO:0000250}. Note=Male meiotic chromosomes.
CC       {ECO:0000250|UniProtKB:Q7K4M4}.
CC   -!- MISCELLANEOUS: Drosophilid specific gene duplication generates rgr and
CC       tef. Teflon has a function unique to Drosophilids.
CC       {ECO:0000250|UniProtKB:Q7K4M4}.
CC   -!- SIMILARITY: Belongs to the Teflon family. {ECO:0000305}.
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DR   EMBL; CM000158; EDW92197.1; -; Genomic_DNA.
DR   EMBL; FJ219517; ACI96575.1; -; Genomic_DNA.
DR   RefSeq; XP_002092485.1; XM_002092449.2.
DR   AlphaFoldDB; B4P8I0; -.
DR   SMR; B4P8I0; -.
DR   STRING; 7245.FBpp0259229; -.
DR   PRIDE; B4P8I0; -.
DR   EnsemblMetazoa; FBtr0260737; FBpp0259229; FBgn0231839.
DR   GeneID; 6531694; -.
DR   KEGG; dya:Dyak_GE14219; -.
DR   eggNOG; ENOG502T9CV; Eukaryota.
DR   HOGENOM; CLU_014432_0_0_1; -.
DR   OMA; TKEHNVY; -.
DR   OrthoDB; 602441at2759; -.
DR   PhylomeDB; B4P8I0; -.
DR   Proteomes; UP000002282; Chromosome 2R.
DR   GO; GO:0030849; C:autosome; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0051308; P:male meiosis chromosome separation; ISS:UniProtKB.
DR   GO; GO:0007141; P:male meiosis I; IEA:EnsemblMetazoa.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   SMART; SM00355; ZnF_C2H2; 3.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 2.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 1.
PE   3: Inferred from homology;
KW   Cell cycle; Chromosome; Chromosome partition; Meiosis; Metal-binding;
KW   Nucleus; Repeat; Zinc; Zinc-finger.
FT   CHAIN           1..648
FT                   /note="Protein teflon"
FT                   /id="PRO_0000377413"
FT   ZN_FING         33..56
FT                   /note="C2H2-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         598..620
FT                   /note="C2H2-type 2; degenerate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         624..647
FT                   /note="C2H2-type 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   REGION          76..127
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          146..170
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        81..96
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        97..118
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        146..162
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        147..151
FT                   /note="Missing (in Ref. 2; ACI96575)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        262..263
FT                   /note="Missing (in Ref. 2; ACI96575)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        310..311
FT                   /note="Missing (in Ref. 2; ACI96575)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   648 AA;  73221 MW;  403D7FF2C9D97756 CRC64;
     MSTFLDMLSG SQCVSLEKCG DVVVSTNDCM IALYCHFCRD LFTQLPEFLR HLQGAHSDVL
     HFTKEHNVYS VEELMSGEQE DAQSVGHNSS SSDSRGLAKS EDSRATEATE DNSDNSPVKS
     EEKGSQNEIN LLAEVTNILL QTKEKEHIND KLKPENGGFK GPRKKANSES NSLRICNLKS
     HTIARTSRKR MSIIKNRILR VIDSDLSANH EMKPSEPNSK ILITEPIQEA NIPGICLETP
     PKPIPSSSNL SVRKSSLTEA NVSLAHTNYA AKKTTPTLPK LLNCAPKPIL PSQQAQVHSG
     SSGIHEVYHI SKAASQVPKE MKSFPIEITQ IDVFPPRILP ETSTTSDKEE DVNAPVENNT
     RSLYNAQNLP KDKPKKFFKK RGELWMKNEG KITKSKVNPI IVKQVQTSNV KSSPGKTQIR
     SSDKTKCFAS EFNSTKNRKL KMENFIALKK EDPCSIRSIR LNKMATIGNC EILKVVGLPA
     ITDNQIEDTL LQDELETMRK KADQFSKIYR KYDSIWNYRK IVPPGKPEHI SQKMFALTRE
     VNQTMGCNLP NSAIKNIINQ ISVWHYNIYT KNIVLDTISE TARYTLNLFS FLPVSFAYFC
     KCCDDIFTLN EDYIRHLVSQ QARYQCTKCI KTFKYQGHYD KHMRTVHP