ID   TEG1_EHV1V              Reviewed;         750 AA.
AC   Q6S6Q7;
DT   15-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   02-JUN-2021, entry version 39.
DE   RecName: Full=Tegument protein UL46 homolog;
DE   AltName: Full=Tegument protein VP11/12 homolog;
GN   ORFNames=14;
OS   Equine herpesvirus 1 (strain V592) (EHV-1) (Equine abortion virus).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Alphaherpesvirinae; Varicellovirus.
OX   NCBI_TaxID=310273;
OH   NCBI_TaxID=9796; Equus caballus (Horse).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Davis-Poynter N.J., Nugent J., Birch-Machin I., Allen G.P.;
RL   Submitted (NOV-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Modulates alpha trans-inducing factor-dependent activation of
CC       alpha genes. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Virion tegument {ECO:0000250|UniProtKB:P10230}.
CC       Host cell membrane {ECO:0000250|UniProtKB:P10230}; Peripheral membrane
CC       protein {ECO:0000250|UniProtKB:P10230}.
CC   -!- SIMILARITY: Belongs to the herpesviridae HHV-1 VP11/12 protein family.
CC       {ECO:0000305}.
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DR   EMBL; AY464052; AAS45898.1; -; Genomic_DNA.
DR   PRIDE; Q6S6Q7; -.
DR   Proteomes; UP000008296; Genome.
DR   GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0019033; C:viral tegument; IEA:UniProtKB-SubCell.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   InterPro; IPR005051; Herpes_UL46.
DR   Pfam; PF03387; Herpes_UL46; 1.
PE   3: Inferred from homology;
KW   Activator; Host cell membrane; Host membrane; Membrane; Transcription;
KW   Transcription regulation; Virion; Virion tegument.
FT   CHAIN           1..750
FT                   /note="Tegument protein UL46 homolog"
FT                   /id="PRO_0000115796"
FT   REGION          437..484
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          525..593
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          610..669
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          692..750
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        466..484
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        525..557
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        636..654
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        706..727
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   750 AA;  82650 MW;  A83771A36C5DF200 CRC64;
     MDGGGSSSWT HVSKNLIERR AVKGCLLPTP SDVMDAAVMA LKDVTENIVG QQLFSVDRTN
     ALSVIHTNEV PESIIATAIA RDTSRDYLRE YEGAAKCNLA ATDLSHDEMW EVVIKRYWRY
     LRESSGAEVV DRGAVGQATQ SVLSVLLLQS TFGKKRLSKN PFKHKGPNVG YKSNLEDLRS
     AFTKIEKYMY YMRPNDPMTK SEDTELRLHE LLAYVTTCYR WLLWFMDLTD AKVLRNIDKG
     PVITHGPRES RPPDELVRRH LKSGPAISAG TGVALTLSTA TADALIVLLR MSVSWTSHSW
     KSNTHGVTGA IVAAVELVTL IHHHLQYIIN TVFAGYVCWL DGGVENSYLN SALRSQGRFD
     HFVGKLVPIM ATLSWANMEK GTVMWFKYAL AKSIVCHGSP TQHYLTVLES IASKRTGACP
     PQGSTFGRNP SGFPGQFCCP PQGPLPAPPN SKTRGTFRRC RPGSLRSSRQ LPTSPPSNIV
     SPRTNPAIEG STAAKNVQGA ETIQVRSSGE FNDCIWYING AYPHQRSDSS SSDNSTCSST
     ETQYITLPST PSPTGDVVYT NPLLGPDEEV DASPQPVDPM SDYSAPKNPD YMRPRSTLVE
     EVWQLRDSDY TPYMRPSRPS RAGRSRVRVE DQTLEPSSPA GCNPPANSPE NDSDDAAVDS
     PPISPEVVYG TFRPRAKCVY DQYGLTALAA LSASRAKARR TRPGPTQPDV CRERDEESAE
     PRHDGFIRRT MSTTGPPRKH PDQTERVSSL