ID   TEG1_EHV4               Reviewed;         743 AA.
AC   Q00041; O39256;
DT   01-DEC-1992, integrated into UniProtKB/Swiss-Prot.
DT   24-NOV-2009, sequence version 2.
DT   25-MAY-2022, entry version 66.
DE   RecName: Full=Tegument protein UL46 homolog;
DE   AltName: Full=Tegument protein VP11/12 homolog;
GN   ORFNames=14, B7;
OS   Equine herpesvirus 4 (strain 1942) (EHV-4) (Equine rhinopneumonitis virus).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Alphaherpesvirinae; Varicellovirus.
OX   NCBI_TaxID=10333;
OH   NCBI_TaxID=9796; Equus caballus (Horse).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NS80567;
RX   PubMed=9603335; DOI=10.1099/0022-1317-79-5-1197;
RA   Telford E.A., Watson M.S., Perry J., Cullinane A.A., Davison A.J.;
RT   "The DNA sequence of equine herpesvirus-4.";
RL   J. Gen. Virol. 79:1197-1203(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-43.
RX   PubMed=1850013; DOI=10.1128/jvi.65.5.2320-2326.1991;
RA   Whittaker G.R., Riggio M.P., Halliburton I.W., Killington R.A., Allen G.P.,
RA   Meredith D.M.;
RT   "Antigenic and protein sequence homology between VP13/14, a herpes simplex
RT   virus type 1 tegument protein, and gp10, a glycoprotein of equine
RT   herpesvirus 1 and 4.";
RL   J. Virol. 65:2320-2326(1991).
CC   -!- FUNCTION: Abundant tegument protein. Trans-activates the immediate
CC       early genes (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with VP16. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Virion tegument {ECO:0000250|UniProtKB:P10230}.
CC       Host cell membrane {ECO:0000250|UniProtKB:P10230}; Peripheral membrane
CC       protein {ECO:0000250|UniProtKB:P10230}.
CC   -!- SIMILARITY: Belongs to the herpesviridae HHV-1 VP11/12 protein family.
CC       {ECO:0000305}.
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DR   EMBL; AF030027; AAC59528.1; -; Genomic_DNA.
DR   EMBL; X17684; CAA35673.1; -; Genomic_DNA.
DR   PIR; S36709; S36709.
DR   PIR; T42557; T42557.
DR   RefSeq; NP_045231.1; NC_001844.1.
DR   PRIDE; Q00041; -.
DR   GeneID; 1487577; -.
DR   KEGG; vg:1487577; -.
DR   Proteomes; UP000009245; Genome.
DR   GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0019033; C:viral tegument; IEA:UniProtKB-SubCell.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   InterPro; IPR005051; Herpes_UL46.
DR   Pfam; PF03387; Herpes_UL46; 1.
PE   3: Inferred from homology;
KW   Activator; Host cell membrane; Host membrane; Membrane; Transcription;
KW   Transcription regulation; Virion; Virion tegument.
FT   CHAIN           1..743
FT                   /note="Tegument protein UL46 homolog"
FT                   /id="PRO_0000115794"
FT   REGION          437..481
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          522..590
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          693..743
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        467..481
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        522..554
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        570..590
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   743 AA;  81393 MW;  EBD80F6D3DAA67CB CRC64;
     MEASGSASWA RVSKNLIERR AVKGCLLPTP SDVMDAAVMA LKDATENVVS KHLFSVDRTN
     ALSVIHTNAV PESIITTAIL RDTNGEYRRE YEDSAKCNLA ATDLSQDGMW EVVIKSYWRY
     LRESSGAEVV DRGGVGNTTQ SVLSVLILQS TFGKKRLSKN PFKHKGPNVS YKSNLENLRA
     AFTKIEKYMY YMRPNDPMTK SEDTELRLHE LLAYVATCYR WLLWFMDLTD AKVLKNIDKG
     PVITHGPRET RPPDELVRRH LKSGPAISAG TGDALTLSTA TADALIVLLR MSVSWTSHSW
     KSNTHGVTGA IVAAVELVTL IHHHLQYIIN TIFAGYVCWL DGGVENSYLN SALRNQGRFD
     HFAGKLVPIM ATLSWANMEK GTVMWFKYAL AKSIVCHGSP TQHYLTVLDS IASKRTGAGL
     PPGATFGRTA NFQGQFGCPP QGPLPAPPNS KTKSMFKRPG RGSVRSLKQL PASTPNMVSS
     ATTYNAGGNT AATSGQGEEA IQIHASGELN DCIWYLNGTY SHQRSDSSSS DNSSCSSTET
     EYITISSTPS PTREVVYTDP LLGSDEEKDA SPQPANTVSE YSSPANSGYM RPRSTLAEEI
     WQLRDSDYTP YMRPSRAGRP RLRLEDQTLQ TLPGCKPPAN SPEDNFEDTL FSSSQIYSDN
     AHSTFRPRAR CVDDEYGLTA LAALSASQAK ARRVRLGTTT PTSANEATEK YTTPSSGGCI
     RRTLSTSESP ESSPEQQERV SSL