TEG1_EHV4
ID TEG1_EHV4 Reviewed; 743 AA.
AC Q00041; O39256;
DT 01-DEC-1992, integrated into UniProtKB/Swiss-Prot.
DT 24-NOV-2009, sequence version 2.
DT 25-MAY-2022, entry version 66.
DE RecName: Full=Tegument protein UL46 homolog;
DE AltName: Full=Tegument protein VP11/12 homolog;
GN ORFNames=14, B7;
OS Equine herpesvirus 4 (strain 1942) (EHV-4) (Equine rhinopneumonitis virus).
OC Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC Herpesvirales; Herpesviridae; Alphaherpesvirinae; Varicellovirus.
OX NCBI_TaxID=10333;
OH NCBI_TaxID=9796; Equus caballus (Horse).
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NS80567;
RX PubMed=9603335; DOI=10.1099/0022-1317-79-5-1197;
RA Telford E.A., Watson M.S., Perry J., Cullinane A.A., Davison A.J.;
RT "The DNA sequence of equine herpesvirus-4.";
RL J. Gen. Virol. 79:1197-1203(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-43.
RX PubMed=1850013; DOI=10.1128/jvi.65.5.2320-2326.1991;
RA Whittaker G.R., Riggio M.P., Halliburton I.W., Killington R.A., Allen G.P.,
RA Meredith D.M.;
RT "Antigenic and protein sequence homology between VP13/14, a herpes simplex
RT virus type 1 tegument protein, and gp10, a glycoprotein of equine
RT herpesvirus 1 and 4.";
RL J. Virol. 65:2320-2326(1991).
CC -!- FUNCTION: Abundant tegument protein. Trans-activates the immediate
CC early genes (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Interacts with VP16. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Virion tegument {ECO:0000250|UniProtKB:P10230}.
CC Host cell membrane {ECO:0000250|UniProtKB:P10230}; Peripheral membrane
CC protein {ECO:0000250|UniProtKB:P10230}.
CC -!- SIMILARITY: Belongs to the herpesviridae HHV-1 VP11/12 protein family.
CC {ECO:0000305}.
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DR EMBL; AF030027; AAC59528.1; -; Genomic_DNA.
DR EMBL; X17684; CAA35673.1; -; Genomic_DNA.
DR PIR; S36709; S36709.
DR PIR; T42557; T42557.
DR RefSeq; NP_045231.1; NC_001844.1.
DR PRIDE; Q00041; -.
DR GeneID; 1487577; -.
DR KEGG; vg:1487577; -.
DR Proteomes; UP000009245; Genome.
DR GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0019033; C:viral tegument; IEA:UniProtKB-SubCell.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR InterPro; IPR005051; Herpes_UL46.
DR Pfam; PF03387; Herpes_UL46; 1.
PE 3: Inferred from homology;
KW Activator; Host cell membrane; Host membrane; Membrane; Transcription;
KW Transcription regulation; Virion; Virion tegument.
FT CHAIN 1..743
FT /note="Tegument protein UL46 homolog"
FT /id="PRO_0000115794"
FT REGION 437..481
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 522..590
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 693..743
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 467..481
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 522..554
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 570..590
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 743 AA; 81393 MW; EBD80F6D3DAA67CB CRC64;
MEASGSASWA RVSKNLIERR AVKGCLLPTP SDVMDAAVMA LKDATENVVS KHLFSVDRTN
ALSVIHTNAV PESIITTAIL RDTNGEYRRE YEDSAKCNLA ATDLSQDGMW EVVIKSYWRY
LRESSGAEVV DRGGVGNTTQ SVLSVLILQS TFGKKRLSKN PFKHKGPNVS YKSNLENLRA
AFTKIEKYMY YMRPNDPMTK SEDTELRLHE LLAYVATCYR WLLWFMDLTD AKVLKNIDKG
PVITHGPRET RPPDELVRRH LKSGPAISAG TGDALTLSTA TADALIVLLR MSVSWTSHSW
KSNTHGVTGA IVAAVELVTL IHHHLQYIIN TIFAGYVCWL DGGVENSYLN SALRNQGRFD
HFAGKLVPIM ATLSWANMEK GTVMWFKYAL AKSIVCHGSP TQHYLTVLDS IASKRTGAGL
PPGATFGRTA NFQGQFGCPP QGPLPAPPNS KTKSMFKRPG RGSVRSLKQL PASTPNMVSS
ATTYNAGGNT AATSGQGEEA IQIHASGELN DCIWYLNGTY SHQRSDSSSS DNSSCSSTET
EYITISSTPS PTREVVYTDP LLGSDEEKDA SPQPANTVSE YSSPANSGYM RPRSTLAEEI
WQLRDSDYTP YMRPSRAGRP RLRLEDQTLQ TLPGCKPPAN SPEDNFEDTL FSSSQIYSDN
AHSTFRPRAR CVDDEYGLTA LAALSASQAK ARRVRLGTTT PTSANEATEK YTTPSSGGCI
RRTLSTSESP ESSPEQQERV SSL