ID   TEG1_GAHVM              Reviewed;         568 AA.
AC   Q77MR6;
DT   05-APR-2011, integrated into UniProtKB/Swiss-Prot.
DT   13-OCT-2009, sequence version 1.
DT   02-JUN-2021, entry version 30.
DE   RecName: Full=Tegument protein UL46 homolog;
DE   AltName: Full=Tegument protein VP11/12 homolog;
GN   ORFNames=MDV059;
OS   Gallid herpesvirus 2 (strain Chicken/Md5/ATCC VR-987) (GaHV-2) (Marek's
OS   disease herpesvirus type 1).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Alphaherpesvirinae; Mardivirus.
OX   NCBI_TaxID=10389;
OH   NCBI_TaxID=9031; Gallus gallus (Chicken).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=10933706; DOI=10.1128/jvi.74.17.7980-7988.2000;
RA   Tulman E.R., Afonso C.L., Lu Z., Zsak L., Rock D.L., Kutish G.F.;
RT   "The genome of a very virulent Marek's disease virus.";
RL   J. Virol. 74:7980-7988(2000).
CC   -!- FUNCTION: Abundant tegument protein. Trans-activates the immediate
CC       early genes (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Virion tegument {ECO:0000250|UniProtKB:P10230}.
CC       Host cell membrane {ECO:0000250|UniProtKB:P10230}; Peripheral membrane
CC       protein {ECO:0000250|UniProtKB:P10230}.
CC   -!- SIMILARITY: Belongs to the herpesviridae HHV-1 VP11/12 protein family.
CC       {ECO:0000305}.
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DR   EMBL; AF243438; AAG14239.1; -; Genomic_DNA.
DR   RefSeq; YP_001033975.1; NC_002229.3.
DR   PRIDE; Q77MR6; -.
DR   GeneID; 4811520; -.
DR   KEGG; vg:4811520; -.
DR   Proteomes; UP000008072; Genome.
DR   GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0019033; C:viral tegument; IEA:UniProtKB-SubCell.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   InterPro; IPR005051; Herpes_UL46.
DR   Pfam; PF03387; Herpes_UL46; 1.
PE   3: Inferred from homology;
KW   Activator; Host cell membrane; Host membrane; Membrane; Reference proteome;
KW   Transcription; Transcription regulation; Virion; Virion tegument.
FT   CHAIN           1..568
FT                   /note="Tegument protein UL46 homolog"
FT                   /id="PRO_0000406520"
FT   REGION          484..530
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        488..530
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   568 AA;  63924 MW;  6D88474526703B58 CRC64;
     MKRLSSSEQS LELFDRDSPQ EYSCILPNEL TVSASALRAL EDSLIEKLPS GLTLGIRESV
     LCETLSNKVP ESVIVHLALG DVRGEYISLY SANVKRRLKR AALTPAVVKD YYTDSYQRYV
     CKRRRIPCVD LPGTREPARS TVALLFYPAI QRNPLTQKPF RLQKDNKMFV KCWAEIWDAL
     NFIQKYVYYM RPDEITTPSL DTSARLELLF GYVKTLYMWA MWLMDLLDTR IVSNKFGTRV
     PISIDNIFSN LTEVMGSLSS DKWMSTALLC RSIEHLLSSL IHISSLWTCC QWRETKHGEM
     LRPIVSIVAL VSLLHHHCQY IINITFNGYA RWLEGGLGNP MLRSAIRQQK RFEHYLGGLF
     PSIRPTAWGE LEFSIRAWFE LALAKSMVIH GSLLKKSIVS NNVLEPLCKP RHTQIGERHD
     TRFTRSTSMP SSSGHIHSTL QNNQQAIVPE CSSGQLSSIA TALWSADELQ NDYVEMKGGV
     LCPAPQPADS ITPNSSQTNN GTASDGSPTR VTDASLDPTE VESSTTVAET PPVTVAVESV
     YVCRETARNK SPSSKVERIL RRLRVATD