ID   TEG1_HHV1F              Reviewed;         715 AA.
AC   P08314;
DT   01-AUG-1988, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1988, sequence version 1.
DT   03-AUG-2022, entry version 64.
DE   RecName: Full=Tegument protein UL46;
DE   AltName: Full=Tegument protein VP11/12;
GN   ORFNames=UL46;
OS   Human herpesvirus 1 (strain F) (HHV-1) (Human herpes simplex virus 1).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Alphaherpesvirinae; Simplexvirus.
OX   NCBI_TaxID=10304;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=3029433; DOI=10.1128/jvi.61.4.992-1001.1987;
RA   McKnight J.L.C., Pellett P.E., Jenkins F.J., Roizman B.;
RT   "Characterization and nucleotide sequence of two herpes simplex virus 1
RT   genes whose products modulate alpha-trans-inducing factor-dependent
RT   activation of alpha genes.";
RL   J. Virol. 61:992-1001(1987).
CC   -!- FUNCTION: Plays a role in the activation of the host PI3K/AKT pathway
CC       to promote cell survival. Interacts with and activates host LCK and
CC       thereby recruits downstream partners SHC1, GRB2 and PI3KR1 in order to
CC       activate the PI3K pathway by phosphorylating host AKT on its activating
CC       residues. This mechanism is inhibited by the viral protein US3 that
CC       instead promotes incorporation of UL46 into virions.
CC       {ECO:0000250|UniProtKB:P10230}.
CC   -!- SUBUNIT: Interacts with VP16. Interacts with host LCK, PIK3R1, SHC1 AND
CC       GRB2; these interactions promote the activation of the PI3K/AKT
CC       pathway. Interacts with host YWHAB. Interacts with ICP0; this
CC       interaction targets UL46 for degradation by the proteasome.
CC       {ECO:0000250|UniProtKB:P10230}.
CC   -!- SUBCELLULAR LOCATION: Virion tegument {ECO:0000250|UniProtKB:P10230}.
CC       Host cell membrane {ECO:0000250|UniProtKB:P10230}; Peripheral membrane
CC       protein {ECO:0000250|UniProtKB:P10230}.
CC   -!- PTM: Phosphorylated by host LCK. The phosphorylation seems to be
CC       lymphocyte-specific. {ECO:0000250|UniProtKB:P10230}.
CC   -!- SIMILARITY: Belongs to the herpesviridae HHV-1 VP11/12 protein family.
CC       {ECO:0000305}.
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DR   EMBL; M15621; AAA45768.1; -; Genomic_DNA.
DR   PIR; B26133; TNBE77.
DR   PRIDE; P08314; -.
DR   GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0019033; C:viral tegument; IEA:UniProtKB-SubCell.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   InterPro; IPR005051; Herpes_UL46.
DR   Pfam; PF03387; Herpes_UL46; 1.
PE   3: Inferred from homology;
KW   Activator; Host cell membrane; Host membrane; Membrane; Phosphoprotein;
KW   Transcription; Transcription regulation; Virion; Virion tegument.
FT   CHAIN           1..715
FT                   /note="Tegument protein UL46"
FT                   /id="PRO_0000115793"
FT   REGION          432..513
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          585..605
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          659..680
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        465..479
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        486..503
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        663..679
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   715 AA;  77357 MW;  9490E875ADD88155 CRC64;
     MQRRTRGASS LRLARCLTPA NLIRGDNAGV PERRIFGGCL LPTPEGLLSA AVGALRQRSD
     DAQPAFLTCT DRSVRLAARQ HNTVPESLIV DGLASDPHYE YIRHYASAAT QALGEVELTG
     GQLSRAILTQ YWKYLQTVVP SGLDVPEDPV GDCDPSLHVL LRPTLAPKLL ARTPFKSGAA
     AAKYAATVAG LRDALHRIQQ YMFFMRPADP SRPSTDTALR LNELLAYVSV LYRWASWMLW
     TTDKHVCHRL SPSNRRFLPL GGSPEAPAET FARHLDRGPS GTTGSMQCMA LRAAVSDVLG
     HLTRLANLWQ TGKRSGGTYG TVDTVVSTVE VLSIVHHHAQ YIINATLTGY GVWATDSLNN
     EYLRAAVDSQ ERFCRTTAPL FPTMTAPSWA RMELSIKAWF GAALAADLLR SGAPSLHYES
     ILRLVASRRT TWSAGPPPDD MARGPGGHRA GGGTVGKRFS GPARQRAPAP PPTSPTLDPR
     GHPAVPEAPR GRPAPPLPDA DDPVAEPPGC AAQPATYYTH MGEVPPRLPA RNVAGPDRRP
     PAATCPLLVR RASLGSLDRP RGWGPAPEGE PDQMEATYLT ADDDDDARRK ATHAASARER
     HAPYEDDESI YETVSEDGGR VYEEIPWMRV YENVCANTAN AAPASPYIEA ENPLYDWGGS
     ALFSPPPRPP PPPPLSPSPV LARHRANALT NDGPTNVAAL SALLTKLKRE GRRSR