ID   TEG1_VZVD               Reviewed;         661 AA.
AC   P09264;
DT   01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1989, sequence version 1.
DT   23-FEB-2022, entry version 67.
DE   RecName: Full=Tegument protein UL46 homolog;
DE   AltName: Full=Tegument protein VP11/12 homolog;
GN   ORFNames=ORF12;
OS   Varicella-zoster virus (strain Dumas) (HHV-3) (Human herpesvirus 3).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Alphaherpesvirinae; Varicellovirus.
OX   NCBI_TaxID=10338;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=3018124; DOI=10.1099/0022-1317-67-9-1759;
RA   Davison A.J., Scott J.E.;
RT   "The complete DNA sequence of varicella-zoster virus.";
RL   J. Gen. Virol. 67:1759-1816(1986).
CC   -!- FUNCTION: Abundant tegument protein. Trans-activates the immediate
CC       early genes (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Virion tegument {ECO:0000250}. Host membrane
CC       {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the herpesviridae HHV-1 VP11/12 protein family.
CC       {ECO:0000305}.
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DR   EMBL; X04370; CAA27895.1; -; Genomic_DNA.
DR   PIR; C27342; TNBE12.
DR   PRIDE; P09264; -.
DR   Proteomes; UP000002602; Genome.
DR   GO; GO:0033644; C:host cell membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0019033; C:viral tegument; IEA:UniProtKB-SubCell.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   InterPro; IPR005051; Herpes_UL46.
DR   Pfam; PF03387; Herpes_UL46; 1.
PE   3: Inferred from homology;
KW   Host membrane; Membrane; Reference proteome; Transcription;
KW   Transcription regulation; Transmembrane; Transmembrane helix; Virion;
KW   Virion tegument.
FT   CHAIN           1..661
FT                   /note="Tegument protein UL46 homolog"
FT                   /id="PRO_0000115797"
FT   TRANSMEM        299..319
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        339..359
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          1..31
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   661 AA;  74273 MW;  C5CA77A16D365379 CRC64;
     MFSRFARSFS SDDRTRKSYD GSYQSFNAGE RDLPTPTRDW CSISQRITSE RVRDGCLIPT
     PGEALETAVK ALSEKTDSLT SPVLQSTERH SVLLGLHHNN VPESLVVSCM SNDVHDGFMQ
     RYMETIQRCL DDLKLSGDGL WWVYENTYWQ YLKYTTGAEV PVTSEKVNKK SKSTVLLFSS
     VVANKPISRH PFKSKVINSD YRGICQELRE ALGAVQKYMY FMRPDDPTNP SPDTRIRVQE
     IAAYTATGYG WMLWFLDVVD ARVCRHLKLQ FRRIRGPRAS VIPDDLLRRH LKTGPAVSAG
     TGVAFILAAT TASALTALLR ISVLWRKEEW RDGLNGTAAA IVAAVELITL LHHHFQYLIN
     MMLIGYACWG DGGLNDPYIL KALRAQGRFL YFAGQLVRTM STHSWVVLET STHMWFSRAV
     AQSILAHGGK PTKYYAQVLA ASKRYTPLHL RRISEPSSVS DQPYIRFNRL GSPIGTGIGN
     LECVCLTGNY LSDDVNASSH VINTEAPLNS IAPDTNRQRT SRVLVRPDTG LDVTVRKNHC
     LDIGHTDGSP VDPTYPDHYT RIKAEYEGPV RDESNTMFDQ RSDLRHIETQ ASLNDHVYEN
     IPPKEVGFNS SSDLDVDSLN GYTSGDMHTD DDLSPDFIPN DVPVRCKTTV TFRKNTPKSH
     H