TEG1_VZVO
ID TEG1_VZVO Reviewed; 661 AA.
AC Q4JQW3;
DT 22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT 24-MAR-2009, sequence version 1.
DT 23-FEB-2022, entry version 39.
DE RecName: Full=Tegument protein UL46 homolog;
DE AltName: Full=Tegument protein VP11/12 homolog;
GN ORFNames=ORF12;
OS Varicella-zoster virus (strain Oka vaccine) (HHV-3) (Human herpesvirus 3).
OC Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC Herpesvirales; Herpesviridae; Alphaherpesvirinae; Varicellovirus.
OX NCBI_TaxID=341980;
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate Human/Japan/P-Oka/1970, and
RC Oka varicella vaccine Biken (V-Oka-Biken);
RX PubMed=12388706; DOI=10.1128/jvi.76.22.11447-11459.2002;
RA Gomi Y., Sunamachi H., Mori Y., Nagaike K., Takahashi M., Yamanishi K.;
RT "Comparison of the complete DNA sequences of the Oka varicella vaccine and
RT its parental virus.";
RL J. Virol. 76:11447-11459(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Oka varicella vaccine VarilRix (V-Oka-GSK), and
RC Oka varicella vaccine Varivax V-Oka-Merk);
RX PubMed=18787000; DOI=10.1128/jvi.00777-08;
RA Tillieux S.L., Halsey W.S., Thomas E.S., Voycik J.J., Sathe G.M.,
RA Vassilev V.;
RT "Complete DNA sequences of two oka strain varicella-zoster virus genomes.";
RL J. Virol. 82:11023-11044(2008).
RN [3]
RP FUNCTION, AND SUBCELLULAR LOCATION.
RX PubMed=22238304; DOI=10.1128/jvi.06923-11;
RA Liu X., Li Q., Dowdell K., Fischer E.R., Cohen J.I.;
RT "Varicella-Zoster virus ORF12 protein triggers phosphorylation of ERK1/2
RT and inhibits apoptosis.";
RL J. Virol. 86:3143-3151(2012).
RN [4]
RP FUNCTION.
RX PubMed=23192871; DOI=10.1128/jvi.02395-12;
RA Liu X., Cohen J.I.;
RT "Varicella-zoster virus ORF12 protein activates the phosphatidylinositol 3-
RT kinase/Akt pathway to regulate cell cycle progression.";
RL J. Virol. 87:1842-1848(2013).
RN [5]
RP FUNCTION.
RX PubMed=24227856; DOI=10.1128/jvi.01695-13;
RA Liu X., Cohen J.I.;
RT "Inhibition of Bim enhances replication of varicella-zoster virus and
RT delays plaque formation in virus-infected cells.";
RL J. Virol. 88:1381-1388(2014).
CC -!- FUNCTION: Plays a role in the activation of the host PI3K/AKT pathway
CC to promote cell survival. Interacts with and activates PI3KR1 in order
CC to phosphorylate host AKT on its activating residues. Activates the
CC host AP-1 pathway by triggering phosphorylation of host ERK1/2.
CC Participates in host BIM and BAD phosphorylation, leading to apoptosis
CC inhibition. {ECO:0000269|PubMed:22238304, ECO:0000269|PubMed:23192871,
CC ECO:0000269|PubMed:24227856}.
CC -!- SUBCELLULAR LOCATION: Virion tegument {ECO:0000269|PubMed:22238304}.
CC Host cytoplasm {ECO:0000269|PubMed:22238304}. Host membrane
CC {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
CC -!- PTM: Phosphorylated by host LCK. The phosphorylation seems to be
CC lymphocyte-specific. {ECO:0000250|UniProtKB:P10230}.
CC -!- SIMILARITY: Belongs to the herpesviridae HHV-1 VP11/12 protein family.
CC {ECO:0000305}.
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DR EMBL; AB097932; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AB097933; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DQ008354; AAY57683.1; -; Genomic_DNA.
DR EMBL; DQ008355; AAY57754.1; -; Genomic_DNA.
DR RefSeq; NP_040135.1; NC_001348.1.
DR IntAct; Q4JQW3; 13.
DR DNASU; 1487655; -.
DR GeneID; 1487655; -.
DR KEGG; vg:1487655; -.
DR Proteomes; UP000002603; Genome.
DR Proteomes; UP000008504; Genome.
DR Proteomes; UP000008505; Genome.
DR Proteomes; UP000008506; Genome.
DR GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0033644; C:host cell membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0019033; C:viral tegument; IEA:UniProtKB-SubCell.
DR GO; GO:0039526; P:modulation by virus of host apoptotic process; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR InterPro; IPR005051; Herpes_UL46.
DR Pfam; PF03387; Herpes_UL46; 1.
PE 3: Inferred from homology;
KW Host cytoplasm; Host membrane; Host-virus interaction; Membrane;
KW Modulation of host cell apoptosis by virus; Transcription;
KW Transcription regulation; Transmembrane; Transmembrane helix; Virion;
KW Virion tegument.
FT CHAIN 1..661
FT /note="Tegument protein UL46 homolog"
FT /id="PRO_0000385463"
FT TRANSMEM 299..319
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 339..359
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 1..31
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 661 AA; 74273 MW; C5CA77A16D365379 CRC64;
MFSRFARSFS SDDRTRKSYD GSYQSFNAGE RDLPTPTRDW CSISQRITSE RVRDGCLIPT
PGEALETAVK ALSEKTDSLT SPVLQSTERH SVLLGLHHNN VPESLVVSCM SNDVHDGFMQ
RYMETIQRCL DDLKLSGDGL WWVYENTYWQ YLKYTTGAEV PVTSEKVNKK SKSTVLLFSS
VVANKPISRH PFKSKVINSD YRGICQELRE ALGAVQKYMY FMRPDDPTNP SPDTRIRVQE
IAAYTATGYG WMLWFLDVVD ARVCRHLKLQ FRRIRGPRAS VIPDDLLRRH LKTGPAVSAG
TGVAFILAAT TASALTALLR ISVLWRKEEW RDGLNGTAAA IVAAVELITL LHHHFQYLIN
MMLIGYACWG DGGLNDPYIL KALRAQGRFL YFAGQLVRTM STHSWVVLET STHMWFSRAV
AQSILAHGGK PTKYYAQVLA ASKRYTPLHL RRISEPSSVS DQPYIRFNRL GSPIGTGIGN
LECVCLTGNY LSDDVNASSH VINTEAPLNS IAPDTNRQRT SRVLVRPDTG LDVTVRKNHC
LDIGHTDGSP VDPTYPDHYT RIKAEYEGPV RDESNTMFDQ RSDLRHIETQ ASLNDHVYEN
IPPKEVGFNS SSDLDVDSLN GYTSGDMHTD DDLSPDFIPN DVPVRCKTTV TFRKNTPKSH
H
