TEG3_HHV11
ID TEG3_HHV11 Reviewed; 219 AA.
AC P04291; B9VQE1; O09797; Q09IB9;
DT 20-MAR-1987, integrated into UniProtKB/Swiss-Prot.
DT 15-AUG-2003, sequence version 2.
DT 23-FEB-2022, entry version 81.
DE RecName: Full=Tegument protein UL14;
GN ORFNames=UL14;
OS Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1).
OC Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC Herpesvirales; Herpesviridae; Alphaherpesvirinae; Simplexvirus.
OX NCBI_TaxID=10299;
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=2839594; DOI=10.1099/0022-1317-69-7-1531;
RA McGeoch D.J., Dalrymple M.A., Davison A.J., Dolan A., Frame M.C., McNab D.,
RA Perry L.J., Scott J.E., Taylor P.;
RT "The complete DNA sequence of the long unique region in the genome of
RT herpes simplex virus type 1.";
RL J. Gen. Virol. 69:1531-1574(1988).
RN [2]
RP SEQUENCE REVISION TO N-TERMINUS.
RX PubMed=9499055; DOI=10.1128/jvi.72.3.2010-2021.1998;
RA Dolan A., Jamieson F.E., Cunningham C., Barnett B.C., McGeoch D.J.;
RT "The genome sequence of herpes simplex virus type 2.";
RL J. Virol. 72:2010-2021(1998).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=3010237; DOI=10.1093/nar/14.8.3435;
RA McGeoch D.J., Dolan A., Frame M.C.;
RT "DNA sequence of the region in the genome of herpes simplex virus type 1
RT containing the exonuclease gene and neighbouring genes.";
RL Nucleic Acids Res. 14:3435-3448(1986).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nonneuroinvasive mutant HF10;
RX PubMed=17218138; DOI=10.1016/j.micinf.2006.10.019;
RA Ushijima Y., Luo C., Goshima F., Yamauchi Y., Kimura H., Nishiyama Y.;
RT "Determination and analysis of the DNA sequence of highly attenuated herpes
RT simplex virus type 1 mutant HF10, a potential oncolytic virus.";
RL Microbes Infect. 9:142-149(2007).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=17 syn+;
RA Cunningham C., Davison A.J.;
RT "Herpes simplex virus type 1 bacterial artificial chromosome.";
RL Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP PHOSPHORYLATION, AND SUBCELLULAR LOCATION.
RX PubMed=10590088; DOI=10.1128/jvi.74.1.33-41.2000;
RA Cunningham C., Davison A.J., MacLean A.R., Taus N.S., Baines J.D.;
RT "Herpes simplex virus type 1 gene UL14: phenotype of a null mutant and
RT identification of the encoded protein.";
RL J. Virol. 74:33-41(2000).
RN [7]
RP FUNCTION.
RX PubMed=18032514; DOI=10.1128/jvi.01226-07;
RA Yamauchi Y., Kiriyama K., Kubota N., Kimura H., Usukura J., Nishiyama Y.;
RT "The UL14 tegument protein of herpes simplex virus type 1 is required for
RT efficient nuclear transport of the alpha transinducing factor VP16 and
RT viral capsids.";
RL J. Virol. 82:1094-1106(2008).
RN [8]
RP INTERACTION WITH UL51.
RX PubMed=27440890; DOI=10.1128/jvi.01258-16;
RA Oda S., Arii J., Koyanagi N., Kato A., Kawaguchi Y.;
RT "The interaction between Herpes Simplex Virus 1 tegument proteins UL51 and
RT UL14 and its role in virion morphogenesis.";
RL J. Virol. 90:8754-8767(2016).
CC -!- FUNCTION: Contributes to the nuclear transport of the viral
CC transcriptional activator VP16 during the early phase of infection.
CC Therefore, participates indirectly in the regulation of the immediate-
CC early gene expression. Additionally, seems to be important for
CC efficient nuclear targeting of capsids. The UL51-UL14 complex regulates
CC final viral envelopment for efficient viral replication
CC (PubMed:27440890). {ECO:0000269|PubMed:18032514,
CC ECO:0000269|PubMed:27440890}.
CC -!- SUBUNIT: Interacts with UL51. {ECO:0000269|PubMed:27440890}.
CC -!- SUBCELLULAR LOCATION: Virion tegument {ECO:0000269|PubMed:10590088}.
CC Host cytoplasm {ECO:0000269|PubMed:10590088}. Host nucleus
CC {ECO:0000269|PubMed:10590088}.
CC -!- PTM: Phosphorylated. {ECO:0000269|PubMed:10590088}.
CC -!- SIMILARITY: Belongs to the alphaherpesvirinae HHV-1 UL14 protein
CC family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAA27455.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; X14112; CAA32327.1; -; Genomic_DNA.
DR EMBL; X03839; CAA27455.1; ALT_SEQ; Genomic_DNA.
DR EMBL; DQ889502; ABI63476.1; -; Genomic_DNA.
DR EMBL; FJ593289; ACM62236.1; -; Genomic_DNA.
DR PIR; A03739; WMBE21.
DR RefSeq; YP_009137088.1; NC_001806.2.
DR SMR; P04291; -.
DR BioGRID; 971422; 1.
DR PRIDE; P04291; -.
DR DNASU; 2703384; -.
DR GeneID; 2703384; -.
DR KEGG; vg:2703384; -.
DR Proteomes; UP000009294; Genome.
DR Proteomes; UP000180652; Genome.
DR GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0019033; C:viral tegument; IEA:UniProtKB-SubCell.
DR InterPro; IPR005207; Herpes_UL14.
DR Pfam; PF03580; Herpes_UL14; 1.
PE 1: Evidence at protein level;
KW Host cytoplasm; Host nucleus; Phosphoprotein; Reference proteome; Virion;
KW Virion tegument.
FT CHAIN 1..219
FT /note="Tegument protein UL14"
FT /id="PRO_0000115935"
FT REGION 161..219
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 174..202
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 109
FT /note="V -> M (in strain: Nonneuroinvasive mutant HF10)"
FT VARIANT 178
FT /note="T -> M (in strain: Nonneuroinvasive mutant HF10)"
FT VARIANT 201
FT /note="P -> A (in strain: Nonneuroinvasive mutant HF10)"
FT CONFLICT 17..18
FT /note="TH -> RP (in Ref. 3)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 219 AA; 23934 MW; 58479A4B7255F3BA CRC64;
MDRDAAHAAL RRRLAETHLR AEIYKDQTLQ LHREGVSTQD PRFVGAFMAA KAAHLELEAR
LKSRARLEMM RQRATCVKIR VEEQAARRDF LTAHRRYLDP ALGERLDAVD DRLADQEEQL
EEAATNASLW GDGDLAEGWM SPADSDLLVM WQLTSAPKVH ANGPSRIGSH PTYTPTPTGP
PGAPAAPLSR TPPSPAPPTG PATDPASASG FARDYPDGE
