ID   TEG3_VZVO               Reviewed;         199 AA.
AC   Q4JQS9;
DT   22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   24-MAR-2009, sequence version 1.
DT   03-AUG-2022, entry version 30.
DE   RecName: Full=Tegument protein UL14 homolog;
GN   ORFNames=ORF46;
OS   Varicella-zoster virus (strain Oka vaccine) (HHV-3) (Human herpesvirus 3).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Alphaherpesvirinae; Varicellovirus.
OX   NCBI_TaxID=341980;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate Human/Japan/P-Oka/1970, and
RC   Oka varicella vaccine Biken (V-Oka-Biken);
RX   PubMed=12388706; DOI=10.1128/jvi.76.22.11447-11459.2002;
RA   Gomi Y., Sunamachi H., Mori Y., Nagaike K., Takahashi M., Yamanishi K.;
RT   "Comparison of the complete DNA sequences of the Oka varicella vaccine and
RT   its parental virus.";
RL   J. Virol. 76:11447-11459(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Oka varicella vaccine VarilRix (V-Oka-GSK), and
RC   Oka varicella vaccine Varivax (V-Oka-Merk);
RX   PubMed=18787000; DOI=10.1128/jvi.00777-08;
RA   Tillieux S.L., Halsey W.S., Thomas E.S., Voycik J.J., Sathe G.M.,
RA   Vassilev V.;
RT   "Complete DNA sequences of two oka strain varicella-zoster virus genomes.";
RL   J. Virol. 82:11023-11044(2008).
CC   -!- FUNCTION: Contributes to the nuclear transport of the viral
CC       transcriptional activator VP16 homolog during the early phase of
CC       infection. Therefore, participates indirectly in the regulation of the
CC       immediate-early gene expression. Additionally, seems to be important
CC       for efficient nuclear targeting of capsids (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Virion tegument {ECO:0000250}. Host cytoplasm
CC       {ECO:0000250}. Host nucleus {ECO:0000250}.
CC   -!- PTM: Phosphorylated. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the alphaherpesvirinae HHV-1 UL14 protein
CC       family. {ECO:0000305}.
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DR   EMBL; AB097932; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AB097933; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; DQ008354; AAY57655.1; -; Genomic_DNA.
DR   EMBL; DQ008355; AAY57726.1; -; Genomic_DNA.
DR   RefSeq; NP_040168.1; NC_001348.1.
DR   SMR; Q4JQS9; -.
DR   IntAct; Q4JQS9; 4.
DR   PRIDE; Q4JQS9; -.
DR   GeneID; 1487720; -.
DR   KEGG; vg:1487720; -.
DR   Proteomes; UP000002603; Genome.
DR   Proteomes; UP000008504; Genome.
DR   Proteomes; UP000008505; Genome.
DR   Proteomes; UP000008506; Genome.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0019033; C:viral tegument; IEA:UniProtKB-SubCell.
DR   InterPro; IPR005207; Herpes_UL14.
DR   Pfam; PF03580; Herpes_UL14; 1.
PE   3: Inferred from homology;
KW   Host cytoplasm; Host nucleus; Virion; Virion tegument.
FT   CHAIN           1..199
FT                   /note="Tegument protein UL14 homolog"
FT                   /id="PRO_0000385152"
FT   REGION          176..199
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   199 AA;  22545 MW;  4CAEBA102D29339B CRC64;
     MSGHTPTYAS HRRNRVKLVE AHNRAGLFKE RTLDLIRGGA SVQDPAFVYA FTAAKEACAD
     LNNQLRSAAR IASVEQKIRD IQSKVEEQTS IQQILNTNRR YIAPDFIRGL DKTEDDNTDN
     IDRLEDAVGP NIEHENHTWF GEDDEALLTQ WMLTTHPPTS KYLQLQDLCV PTTIPTDMNQ
     MQPQPISKNE NPPTPHTDV