TEG4_HHV11
ID TEG4_HHV11 Reviewed; 535 AA.
AC P10205; B9VQE8; Q09IB2;
DT 01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-1989, sequence version 1.
DT 23-FEB-2022, entry version 74.
DE RecName: Full=Tegument protein UL21;
GN ORFNames=UL21;
OS Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1).
OC Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC Herpesvirales; Herpesviridae; Alphaherpesvirinae; Simplexvirus.
OX NCBI_TaxID=10299;
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=2839594; DOI=10.1099/0022-1317-69-7-1531;
RA McGeoch D.J., Dalrymple M.A., Davison A.J., Dolan A., Frame M.C., McNab D.,
RA Perry L.J., Scott J.E., Taylor P.;
RT "The complete DNA sequence of the long unique region in the genome of
RT herpes simplex virus type 1.";
RL J. Gen. Virol. 69:1531-1574(1988).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nonneuroinvasive mutant HF10;
RX PubMed=17218138; DOI=10.1016/j.micinf.2006.10.019;
RA Ushijima Y., Luo C., Goshima F., Yamauchi Y., Kimura H., Nishiyama Y.;
RT "Determination and analysis of the DNA sequence of highly attenuated herpes
RT simplex virus type 1 mutant HF10, a potential oncolytic virus.";
RL Microbes Infect. 9:142-149(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=17 syn+;
RA Cunningham C., Davison A.J.;
RT "Herpes simplex virus type 1 bacterial artificial chromosome.";
RL Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP SUBCELLULAR LOCATION, AND FUNCTION.
RX PubMed=11733033; DOI=10.1046/j.1365-2443.2001.00475.x;
RA Takakuwa H., Goshima F., Koshizuka T., Murata T., Daikoku T., Nishiyama Y.;
RT "Herpes simplex virus encodes a virion-associated protein which promotes
RT long cellular processes in over-expressing cells.";
RL Genes Cells 6:955-966(2001).
RN [5]
RP SUBCELLULAR LOCATION.
RC STRAIN=F;
RX PubMed=18596102; DOI=10.1128/jvi.00904-08;
RA Loret S., Guay G., Lippe R.;
RT "Comprehensive characterization of extracellular herpes simplex virus type
RT 1 virions.";
RL J. Virol. 82:8605-8618(2008).
RN [6]
RP INTERACTION WITH UL16.
RC STRAIN=KOS;
RX PubMed=20042500; DOI=10.1128/jvi.02015-09;
RA Harper A.L., Meckes D.G. Jr., Marsh J.A., Ward M.D., Yeh P.C., Baird N.L.,
RA Wilson C.B., Semmes O.J., Wills J.W.;
RT "Interaction domains of the UL16 and UL21 tegument proteins of herpes
RT simplex virus.";
RL J. Virol. 84:2963-2971(2010).
CC -!- FUNCTION: May participate in DNA packaging/capsid maturation events.
CC Promotes efficient incorporation of tegument proteins UL46, UL49, and
CC US3 into virions. May also play a role in capsid transport to the
CC trans-Golgi network (TGN) (By similarity). {ECO:0000250,
CC ECO:0000269|PubMed:11733033}.
CC -!- SUBUNIT: Interacts (via C-terminus) with UL16.
CC {ECO:0000269|PubMed:20042500}.
CC -!- SUBCELLULAR LOCATION: Virion tegument {ECO:0000269|PubMed:18596102}.
CC Host cytoplasm {ECO:0000269|PubMed:11733033}. Host nucleus
CC {ECO:0000269|PubMed:11733033}.
CC -!- SIMILARITY: Belongs to the alphaherpesvirinae UL21 protein family.
CC {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; X14112; CAA32334.1; -; Genomic_DNA.
DR EMBL; DQ889502; ABI63483.1; -; Genomic_DNA.
DR EMBL; FJ593289; ACM62243.1; -; Genomic_DNA.
DR PIR; C30084; WMBEW1.
DR RefSeq; YP_009137095.1; NC_001806.2.
DR PDB; 4U4H; X-ray; 2.05 A; A=1-198.
DR PDB; 5ED7; X-ray; 2.72 A; A=279-530.
DR PDBsum; 4U4H; -.
DR PDBsum; 5ED7; -.
DR SASBDB; P10205; -.
DR SMR; P10205; -.
DR BioGRID; 971413; 1.
DR PRIDE; P10205; -.
DR DNASU; 2703372; -.
DR GeneID; 2703372; -.
DR KEGG; vg:2703372; -.
DR Proteomes; UP000009294; Genome.
DR Proteomes; UP000180652; Genome.
DR GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0019033; C:viral tegument; IEA:UniProtKB-SubCell.
DR InterPro; IPR004936; Herpes_UL21.
DR Pfam; PF03252; Herpes_UL21; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Host cytoplasm; Host nucleus; Reference proteome; Virion;
KW Virion tegument.
FT CHAIN 1..535
FT /note="Tegument protein UL21"
FT /id="PRO_0000115971"
FT REGION 251..279
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 40
FT /note="C -> Y (in strain: Nonneuroinvasive mutant HF10)"
FT STRAND 1..4
FT /evidence="ECO:0007829|PDB:4U4H"
FT STRAND 6..11
FT /evidence="ECO:0007829|PDB:4U4H"
FT STRAND 14..18
FT /evidence="ECO:0007829|PDB:4U4H"
FT STRAND 22..29
FT /evidence="ECO:0007829|PDB:4U4H"
FT STRAND 32..37
FT /evidence="ECO:0007829|PDB:4U4H"
FT STRAND 47..54
FT /evidence="ECO:0007829|PDB:4U4H"
FT HELIX 63..75
FT /evidence="ECO:0007829|PDB:4U4H"
FT HELIX 90..94
FT /evidence="ECO:0007829|PDB:4U4H"
FT HELIX 103..106
FT /evidence="ECO:0007829|PDB:4U4H"
FT STRAND 111..114
FT /evidence="ECO:0007829|PDB:4U4H"
FT HELIX 117..124
FT /evidence="ECO:0007829|PDB:4U4H"
FT STRAND 132..140
FT /evidence="ECO:0007829|PDB:4U4H"
FT TURN 141..144
FT /evidence="ECO:0007829|PDB:4U4H"
FT STRAND 145..156
FT /evidence="ECO:0007829|PDB:4U4H"
FT TURN 157..159
FT /evidence="ECO:0007829|PDB:4U4H"
FT TURN 167..169
FT /evidence="ECO:0007829|PDB:4U4H"
FT STRAND 170..179
FT /evidence="ECO:0007829|PDB:4U4H"
FT HELIX 182..184
FT /evidence="ECO:0007829|PDB:4U4H"
FT HELIX 185..188
FT /evidence="ECO:0007829|PDB:4U4H"
FT HELIX 191..194
FT /evidence="ECO:0007829|PDB:4U4H"
FT HELIX 284..298
FT /evidence="ECO:0007829|PDB:5ED7"
FT HELIX 303..306
FT /evidence="ECO:0007829|PDB:5ED7"
FT HELIX 309..326
FT /evidence="ECO:0007829|PDB:5ED7"
FT STRAND 329..332
FT /evidence="ECO:0007829|PDB:5ED7"
FT HELIX 344..355
FT /evidence="ECO:0007829|PDB:5ED7"
FT HELIX 364..378
FT /evidence="ECO:0007829|PDB:5ED7"
FT HELIX 390..412
FT /evidence="ECO:0007829|PDB:5ED7"
FT HELIX 427..441
FT /evidence="ECO:0007829|PDB:5ED7"
FT HELIX 453..466
FT /evidence="ECO:0007829|PDB:5ED7"
FT TURN 467..469
FT /evidence="ECO:0007829|PDB:5ED7"
FT HELIX 472..483
FT /evidence="ECO:0007829|PDB:5ED7"
FT HELIX 488..496
FT /evidence="ECO:0007829|PDB:5ED7"
FT HELIX 504..529
FT /evidence="ECO:0007829|PDB:5ED7"
SQ SEQUENCE 535 AA; 57642 MW; 9D0621FF490DA745 CRC64;
MELSYATTMH YRDVVFYVTT DRNRAYFVCG GCVYSVGRPC ASQPGEIAKF GLVVRGTGPD
DRVVANYVRS ELRQRGLQDV RPIGEDEVFL DSVCLLNPNV SSELDVINTN DVEVLDECLA
EYCTSLRTSP GVLISGLRVR AQDRIIELFE HPTIVNVSSH FVYTPSPYVF ALAQAHLPRL
PSSLEALVSG LFDGIPAPRQ PLDAHNPRTD VVITGRRAPR PIAGSGAGSG GAGAKRATVS
EFVQVKHIDR VGPAGVSPAP PPNNTDSSSL VPGAQDSAPP GPTLRELWWV FYAADRALEE
PRADSGLTRE EVRAVRGFRE QAWKLFGSAG APRAFIGAAL GLSPLQKLAV YYYIIHRERR
LSPFPALVRL VGRYTQRHGL YVPRPDDPVL ADAINGLFRD ALAAGTTAEQ LLMFDLLPPK
DVPVGSDVQA DSTALLRFIE SQRLAVPGGV ISPEHVAYLG AFLSVLYAGR GRMSAATHTA
RLTGVTSLVL AVGDVDRLSA FDRGAAGAAS RTRAAGYLDV LLTVRLARSQ HGQSV
