ID   TEG4_HHV1E              Reviewed;         535 AA.
AC   P09855;
DT   01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1989, sequence version 1.
DT   02-JUN-2021, entry version 51.
DE   RecName: Full=Tegument protein UL21;
GN   Name=UL21;
OS   Human herpesvirus 1 (strain HFEM) (HHV-1) (Human herpes simplex virus 1).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Alphaherpesvirinae; Simplexvirus.
OX   NCBI_TaxID=10303;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=3016991; DOI=10.1016/0042-6822(86)90026-7;
RA   Gompels U., Minson A.;
RT   "The properties and sequence of glycoprotein H of herpes simplex virus type
RT   1.";
RL   Virology 153:230-247(1986).
CC   -!- FUNCTION: May participate in DNA packaging/capsid maturation events.
CC       Promotes efficient incorporation of tegument proteins UL46, UL49, and
CC       US3 into virions. May also play a role in capsid transport to the
CC       trans-Golgi network (TGN) (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts (via C-terminus) with UL16. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Virion tegument {ECO:0000250}. Host cytoplasm
CC       {ECO:0000250}. Host nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the alphaherpesvirinae UL21 protein family.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAA45816.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; M14884; AAA45816.1; ALT_INIT; Genomic_DNA.
DR   PIR; C24187; C24187.
DR   SMR; P09855; -.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0019033; C:viral tegument; IEA:UniProtKB-SubCell.
DR   InterPro; IPR004936; Herpes_UL21.
DR   Pfam; PF03252; Herpes_UL21; 1.
PE   3: Inferred from homology;
KW   Host cytoplasm; Host nucleus; Virion; Virion tegument.
FT   CHAIN           1..535
FT                   /note="Tegument protein UL21"
FT                   /id="PRO_0000115972"
FT   REGION          251..279
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   535 AA;  57732 MW;  427EB0CD5ECC605C CRC64;
     MELSYTTTMH YRDVVFYVTT DRNRAYFVCG GCVYSVGRPY ASQPGEIAKF GLVVRGTGPD
     DRVVANYVRS ELRQRGLQDV RPIGEDEVFL DSVCLLNPNV SSELDVINTN DVEVLDECLA
     EYCTSLRTSP GVLISGLRVR AQDRIIELFE HPTIVNVSSH FVYTPSPYVF ALAQAHLPRL
     PSSLEALVSG LFDGIPAPRQ PLDAHNPRTD VVITGRRAPR PIAGSGAGSG GAGAKRATVS
     EFVQVKHIDR VGPAGVSPAP PPNNTDSSSL VPGAQDSAPP GPTLRELWWV FYAADRALEE
     PRADSGLTRE EVRAVRGFRE QAWKLFGSAG APRAFIGAAL GLSPLQKLAV YYYIIHRERR
     LSPFPALVRL VGRYTQRHGL YVPRPDDPVL ADAINGLFRD ALAAGTTAEQ LLMFDLLPPK
     DVPVGSDVQA DSTALLRFIE SQRLAVPGGV ISPEHVAYLG AFLSVLYAGR GRMSAATHTA
     RLTGVTSLVL AVGDVDRLSA FDRGAAGAAS RTRAAGYLDV LLTVRLARSQ HGQSV