ID   TEG4_HHV2H              Reviewed;         532 AA.
AC   P89444;
DT   22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1997, sequence version 1.
DT   02-JUN-2021, entry version 57.
DE   RecName: Full=Tegument protein UL21;
GN   ORFNames=UL21;
OS   Human herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Alphaherpesvirinae; Simplexvirus.
OX   NCBI_TaxID=10315;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=9499055; DOI=10.1128/jvi.72.3.2010-2021.1998;
RA   Dolan A., Jamieson F.E., Cunningham C., Barnett B.C., McGeoch D.J.;
RT   "The genome sequence of herpes simplex virus type 2.";
RL   J. Virol. 72:2010-2021(1998).
CC   -!- FUNCTION: May participate in DNA packaging/capsid maturation events.
CC       Promotes efficient incorporation of tegument proteins UL46, UL49, and
CC       US3 into virions. May also play a role in capsid transport to the
CC       trans-Golgi network (TGN) (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts (via C-terminus) with UL16. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Virion tegument {ECO:0000250}. Host cytoplasm
CC       {ECO:0000250}. Host nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the alphaherpesvirinae UL21 protein family.
CC       {ECO:0000305}.
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DR   EMBL; Z86099; CAB06745.1; -; Genomic_DNA.
DR   RefSeq; YP_009137172.1; NC_001798.2.
DR   SMR; P89444; -.
DR   PRIDE; P89444; -.
DR   DNASU; 1487305; -.
DR   GeneID; 1487305; -.
DR   KEGG; vg:1487305; -.
DR   Proteomes; UP000001874; Genome.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0019033; C:viral tegument; IEA:UniProtKB-SubCell.
DR   InterPro; IPR004936; Herpes_UL21.
DR   Pfam; PF03252; Herpes_UL21; 1.
PE   3: Inferred from homology;
KW   Host cytoplasm; Host nucleus; Reference proteome; Virion; Virion tegument.
FT   CHAIN           1..532
FT                   /note="Tegument protein UL21"
FT                   /id="PRO_0000385153"
FT   REGION          251..276
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        256..276
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   532 AA;  57466 MW;  709245EC16E440CD CRC64;
     MELSYATTLH HRDVVFYVTA DRNRAYFVCG GSVYSVGRPR DSQPGEIAKF GLVVRGTGPK
     DRMVANYVRS ELRQRGLRDV RPVGEDEVFL DSVCLLNPNV SSERDVINTN DVEVLDECLA
     EYCTSLRTSP GVLVTGVRVR ARDRVIELFE HPAIVNISSR FAYTPSPYVF ALAQAHLPRL
     PSSLEPLVSG LFDGIPAPRQ PLDARDRRTD VVITGTRAPR PMAGTGAGGA GAKRATVSEF
     VQVKHIDRVV SPSVSSAPPP SAPDASLPPP GLQEAAPPGP PLRELWWVFY AGDRALEEPH
     AESGLTREEV RAVHGFREQA WKLFGSVGAP RAFLGAALAL SPTQKLAVYY YLIHRERRMS
     PFPALVRLVG RYIQRHGLYV PAPDEPTLAD AMNGLFRDAL AAGTVAEQLL MFDLLPPKDV
     PVGSDARADS AALLRFVDSQ RLTPGGSVSP EHVMYLGAFL GVLYAGHGRL AAATHTARLT
     GVTSLVLTVG DVDRMSAFDR GPAGAAGRTR TAGYLDALLT VCLARAQHGQ SV