ID   TEG4_SUHVN              Reviewed;         523 AA.
AC   Q00703;
DT   01-APR-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1993, sequence version 1.
DT   03-AUG-2022, entry version 44.
DE   RecName: Full=Tegument protein UL21;
GN   Name=UL21;
OS   Suid herpesvirus 1 (strain NIA-3) (SuHV-1) (Pseudorabies virus (strain
OS   NIA-3)).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Alphaherpesvirinae; Varicellovirus.
OX   NCBI_TaxID=10349;
OH   NCBI_TaxID=9823; Sus scrofa (Pig).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=1331512; DOI=10.1128/jvi.66.12.7096-7103.1992;
RA   Berns A.A., Kimman T.T., Pol J.J., Wagenaar F.F., de Wind N.N.;
RT   "The pseudorabies virus homology of the herpes simplex virus UL21 gene
RT   product is a capsid protein which is involved in capsid maturation.";
RL   J. Virol. 66:7096-7103(1992).
RN   [2]
RP   FUNCTION.
RX   PubMed=11254176; DOI=10.1051/vetres:2001108;
RA   Wagenaar F., Pol J.M., de Wind N., Kimman T.G.;
RT   "Deletion of the UL21 gene in Pseudorabies virus results in the formation
RT   of DNA-deprived capsids: an electron microscopy study.";
RL   Vet. Res. 32:47-54(2001).
RN   [3]
RP   INTERACTION WITH UL16.
RX   PubMed=15650177; DOI=10.1128/jvi.79.3.1510-1522.2005;
RA   Klupp B.G., Bottcher S., Granzow H., Kopp M., Mettenleiter T.C.;
RT   "Complex formation between the UL16 and UL21 tegument proteins of
RT   pseudorabies virus.";
RL   J. Virol. 79:1510-1522(2005).
RN   [4]
RP   FUNCTION.
RX   PubMed=17079290; DOI=10.1128/jvi.01801-06;
RA   Michael K., Klupp B.G., Karger A., Mettenleiter T.C.;
RT   "Efficient incorporation of tegument proteins pUL46, pUL49, and pUS3 into
RT   pseudorabies virus particles depends on the presence of pUL21.";
RL   J. Virol. 81:1048-1051(2007).
CC   -!- FUNCTION: May participate in DNA packaging/capsid maturation events.
CC       Promotes efficient incorporation of tegument proteins UL46, UL49, and
CC       US3 into virions. May also play a role in capsid transport to the
CC       trans-Golgi network (TGN). {ECO:0000269|PubMed:11254176,
CC       ECO:0000269|PubMed:17079290}.
CC   -!- SUBUNIT: Interacts (via C-terminus) with UL16. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Virion tegument {ECO:0000250}. Host cytoplasm
CC       {ECO:0000250}. Host nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the alphaherpesvirinae UL21 protein family.
CC       {ECO:0000305}.
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DR   EMBL; M95285; AAA47474.1; -; Genomic_DNA.
DR   PIR; A44195; A44195.
DR   SMR; Q00703; -.
DR   PRIDE; Q00703; -.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0019033; C:viral tegument; IEA:UniProtKB-SubCell.
DR   InterPro; IPR004936; Herpes_UL21.
DR   Pfam; PF03252; Herpes_UL21; 1.
PE   1: Evidence at protein level;
KW   Host cytoplasm; Host nucleus; Virion; Virion tegument.
FT   CHAIN           1..523
FT                   /note="Tegument protein UL21"
FT                   /id="PRO_0000115977"
FT   REGION          340..364
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   523 AA;  55020 MW;  9E69949DAE94CAC6 CRC64;
     MEFEYQSTIV HQGVLFYVAD GGDRAYFVHG GCIVSVHRRS REIGKFGLTL RGNAPGNRVV
     ANYVRTELAR LGRAWAAPQG SDDVFVDALG LLLPLTELDL CGRAELDVYD PYLVECMVSL
     PASALSLTLV HDRQQDRVLE LLAEPAIVHP SSGFVYAVNE ACFALVQAYL SELPSSLQVL
     TEGLFDGIPG VRPPLSGETR PTAVVVKGGR AAPTLSVRPR RYAERALRAT VVSDFVQVRY
     IPATRRIWAT RGGSLSLQML CDLVAGADAI LRRAAGASDD ASAAVVEAVS AVAADPFFGT
     GSTSLTGAQR FALYQFILAR WHLPSCYAAL EGMLDRLDER PGAGAGDDDD GGEGGGGGGH
     GGSRAASAVA HAVNRVLREA TVFGEVMRML VNAAVVHAPA IADPAGASPP TTKHAREDAA
     TGLELAVMMS DAETNALDAD ACELVEAAGA RVLDGLYAGR GLVAATAPVG RALRPTSAVC
     AEAALLTAFG DSPAALRGAQ YLFQLFRARL TRANISIVLN KNR