ID   TEG4_VZVD               Reviewed;         541 AA.
AC   P09289;
DT   01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1989, sequence version 1.
DT   02-JUN-2021, entry version 57.
DE   RecName: Full=Tegument protein UL21 homolog;
GN   ORFNames=ORF38;
OS   Varicella-zoster virus (strain Dumas) (HHV-3) (Human herpesvirus 3).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Alphaherpesvirinae; Varicellovirus.
OX   NCBI_TaxID=10338;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=3018124; DOI=10.1099/0022-1317-67-9-1759;
RA   Davison A.J., Scott J.E.;
RT   "The complete DNA sequence of varicella-zoster virus.";
RL   J. Gen. Virol. 67:1759-1816(1986).
CC   -!- FUNCTION: May participate in DNA packaging/capsid maturation events.
CC       Promotes efficient incorporation of tegument proteins UL46, UL49, and
CC       US3 homologs into virions. May also play a role in capsid transport to
CC       the trans-Golgi network (TGN) (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts (via C-terminus) with UL16. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Virion tegument {ECO:0000250}. Host cytoplasm
CC       {ECO:0000250}. Host nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the alphaherpesvirinae UL21 protein family.
CC       {ECO:0000305}.
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DR   EMBL; X04370; CAA27921.1; -; Genomic_DNA.
DR   PIR; C27341; WZBE38.
DR   SMR; P09289; -.
DR   PRIDE; P09289; -.
DR   Proteomes; UP000002602; Genome.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0019033; C:viral tegument; IEA:UniProtKB-SubCell.
DR   InterPro; IPR004936; Herpes_UL21.
DR   Pfam; PF03252; Herpes_UL21; 1.
PE   3: Inferred from homology;
KW   Host cytoplasm; Host nucleus; Reference proteome; Virion; Virion tegument.
FT   CHAIN           1..541
FT                   /note="Tegument protein UL21 homolog"
FT                   /id="PRO_0000115976"
SQ   SEQUENCE   541 AA;  60399 MW;  8FB1F81BC6EAAE61 CRC64;
     MEFPYHSTVS YNGVTFYFNE RATRAYFICG GCLISIPRKH GGEIAKFGHV VRGVGPGDRS
     VASYVRSELN RTGKTWAVSS NNNCVFLDRV ALLAAGSGAV DRDLCGTFDV EVEDPTLADY
     LVSLPVTHLT LVAGVDVTRE NKLKLFPTPT AINTTNGFMY VPNEASFSLV YMRMLELPES
     LQELVSGLFD GTPEIRDALN GSNDDEKTSI IVSRRAADVV TEDVKADDVP ISGEPYSEKQ
     PRRRKKSDHI TLSNFVQIRT IPRVMDIWDP RHKATTHCIR ALSCAVFFAD EVIFKARKWP
     GLEDELNEAR ETIYTAVVAV YGERGELPFF GHAYGRDLTS CQRFVIVQYI LSRWEAFNCY
     AVIEDLTRSY VNALPSDDDT DQVAQDLIRT IVDTANSLLR EVGFIGTLAE TLLFLPLPQL
     PCYKETSHLA KKEGVRILRL AKTGVGLSDT VPVDVSVTER HEYEISRYLD TLYSGDPCYN
     GAVRLCRLLG SSIPIALYYN TISGNAFEPY FAGRRYIAYL GALFFGRVHQ TPFGDGKKTQ
     R