ID   TEG4_VZVO               Reviewed;         541 AA.
AC   Q4JQT7;
DT   22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   24-MAR-2009, sequence version 1.
DT   12-AUG-2020, entry version 23.
DE   RecName: Full=Tegument protein UL21 homolog;
GN   ORFNames=ORF38;
OS   Varicella-zoster virus (strain Oka vaccine) (HHV-3) (Human herpesvirus 3).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Alphaherpesvirinae; Varicellovirus.
OX   NCBI_TaxID=341980;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate Human/Japan/P-Oka/1970, and
RC   Oka varicella vaccine Biken (V-Oka-Biken);
RX   PubMed=12388706; DOI=10.1128/jvi.76.22.11447-11459.2002;
RA   Gomi Y., Sunamachi H., Mori Y., Nagaike K., Takahashi M., Yamanishi K.;
RT   "Comparison of the complete DNA sequences of the Oka varicella vaccine and
RT   its parental virus.";
RL   J. Virol. 76:11447-11459(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Oka varicella vaccine VarilRix (V-Oka-GSK), and
RC   Oka varicella vaccine Varivax (V-Oka-Merk);
RX   PubMed=18787000; DOI=10.1128/jvi.00777-08;
RA   Tillieux S.L., Halsey W.S., Thomas E.S., Voycik J.J., Sathe G.M.,
RA   Vassilev V.;
RT   "Complete DNA sequences of two oka strain varicella-zoster virus genomes.";
RL   J. Virol. 82:11023-11044(2008).
CC   -!- FUNCTION: May participate in DNA packaging/capsid maturation events.
CC       Promotes efficient incorporation of tegument proteins UL46, UL49, and
CC       US3 homologs into virions. May also play a role in capsid transport to
CC       the trans-Golgi network (TGN) (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts (via C-terminus) with UL16. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Virion tegument {ECO:0000250}. Host cytoplasm
CC       {ECO:0000250}. Host nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the alphaherpesvirinae UL21 protein family.
CC       {ECO:0000305}.
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DR   EMBL; AB097932; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AB097933; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; DQ008354; AAY57650.1; -; Genomic_DNA.
DR   EMBL; DQ008355; AAY57721.1; -; Genomic_DNA.
DR   SMR; Q4JQT7; -.
DR   IntAct; Q4JQT7; 24.
DR   PRIDE; Q4JQT7; -.
DR   Proteomes; UP000002603; Genome.
DR   Proteomes; UP000008504; Genome.
DR   Proteomes; UP000008505; Genome.
DR   Proteomes; UP000008506; Genome.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0019033; C:viral tegument; IEA:UniProtKB-SubCell.
DR   InterPro; IPR004936; Herpes_UL21.
DR   Pfam; PF03252; Herpes_UL21; 1.
PE   3: Inferred from homology;
KW   Host cytoplasm; Host nucleus; Virion; Virion tegument.
FT   CHAIN           1..541
FT                   /note="Tegument protein UL21 homolog"
FT                   /id="PRO_0000385154"
SQ   SEQUENCE   541 AA;  60369 MW;  0FB314A22170968D CRC64;
     MEFPYHSTVS YNGVTFYFNE RATRAYFICG GCLISIPRKH GGEIAKFGHV VRGVGPGDRS
     VASYVRSELN RTGKTWAVSS NNNCVFLDRV ALLAAGSGAV DRDLCGTFDV EVEDPTLADY
     LVSLPVTHLT LVAGVDVTRE NKLKLFPTPT AINTTNGFMY VPNEASFSLV YMRMLELPEG
     LQELVSGLFD GTPEIRDALN GSNDDEKTSI IVSRRAADVV TEDVKADDVP ISGEPYSEKQ
     PRRRKKSDHI TLSNFVQIRT IPRVMDIWDP RHKATTHCIR ALSCAVFFAD EVIFKARKWP
     GLEDELNEAR ETIYTAVVAV YGERGELPFF GHAYGRDLTS CQRFVIVQYI LSRWEAFNCY
     AVIEDLTRSY VNALPSDDDT DQVAQDLIRT IVDTANSLLR EVGFIGTLAE TLLFLPLPQL
     PCYKETSHLA KKEGVRILRL AKTGVGLSDT VPVDVSVTER HEYEISRYLD TLYSGDPCYN
     GAVRLCRLLG SSIPIALYYN TISGNAFEPY FAGRRYIAYL GALFFGRVHQ TPFGDGKKTQ
     R