TEG5_BHV1C
ID TEG5_BHV1C Reviewed; 739 AA.
AC P36338;
DT 01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-1994, sequence version 1.
DT 03-AUG-2022, entry version 82.
DE RecName: Full=Tegument protein UL47;
GN ORFNames=UL47;
OS Bovine herpesvirus 1.1 (strain Cooper) (BoHV-1) (Infectious bovine
OS rhinotracheitis virus).
OC Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC Herpesvirales; Herpesviridae; Alphaherpesvirinae; Varicellovirus.
OX NCBI_TaxID=10323;
OH NCBI_TaxID=9913; Bos taurus (Bovine).
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Cooper / 34;
RX PubMed=1331296; DOI=10.1099/0022-1317-73-11-2941;
RA Laboissiere S., Trudel M., Simard C.;
RT "Characterization and transcript mapping of a bovine herpesvirus type 1
RT gene encoding a polypeptide homologous to the herpes simplex virus type 1
RT major tegument proteins VP13/14.";
RL J. Gen. Virol. 73:2941-2947(1992).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=9010999; DOI=10.1016/s0378-1135(96)01235-7;
RA Schwyzer M., Styger D., Vogt B., Lowery D.E., Simard C., LaBoissiere S.,
RA Misra V., Vlcek C., Paces V.;
RT "Gene contents in a 31-kb segment at the left genome end of bovine
RT herpesvirus-1.";
RL Vet. Microbiol. 53:67-77(1996).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Schwyzer M., Paces V., Letchworth G.J., Misra V., Buhk H.J., Lowery D.E.,
RA Simard C., Bello L.J., Thiry E., Vlcek C.;
RT "Complete DNA sequence of bovine herpesvirus 1.";
RL Submitted (SEP-1997) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP INTERACTION WITH HOST DDB1, FUNCTION, SUBCELLULAR LOCATION, AND
RP UBIQUITINATION.
RX PubMed=22542975; DOI=10.1016/j.virusres.2012.04.005;
RA Vasilenko N.L., Snider M., Labiuk S.L., Lobanov V.A., Babiuk L.A.,
RA van Drunen Littel-van den Hurk S.;
RT "Bovine herpesvirus-1 VP8 interacts with DNA damage binding protein-1
RT (DDB1) and is monoubiquitinated during infection.";
RL Virus Res. 167:56-66(2012).
RN [5]
RP FUNCTION.
RX PubMed=25529439; DOI=10.1016/j.virusres.2014.12.017;
RA Islam A., Schulz S., Afroz S., Babiuk L.A.,
RA van Drunen Littel-van den Hurk S.;
RT "Interaction of VP8 with mRNAs of bovine herpesvirus-1.";
RL Virus Res. 197C:116-126(2015).
CC -!- FUNCTION: Tegument protein that can bind to various RNA transcripts.
CC Plays a role in the attenuation of selective viral and cellular mRNA
CC degradation by modulating the activity of host shutoff RNase UL41/VHS.
CC Also plays a role in the primary envelopement of virions in the
CC perinuclear space, probably by interacting with two nuclear egress
CC proteins UL31 and UL34. {ECO:0000250|UniProtKB:P10231,
CC ECO:0000269|PubMed:22542975, ECO:0000269|PubMed:25529439}.
CC -!- SUBUNIT: Interacts with US3 kinase. Interacts with UL31 and UL34; these
CC interactions seem important for efficient virion nuclear egress.
CC Interacts with UL41/VHS. Interacts with host DDB1.
CC {ECO:0000250|UniProtKB:P10231, ECO:0000269|PubMed:22542975}.
CC -!- SUBCELLULAR LOCATION: Virion tegument {ECO:0000250|UniProtKB:P10231}.
CC Host nucleus {ECO:0000269|PubMed:22542975}. Host cytoplasm
CC {ECO:0000269|PubMed:22542975}. Note=Major tegument protein of the
CC virion. Undergoes nucleocytoplasmic shuttling during infection.
CC Localizes to the major sites of transcription in the infected cell
CC nucleus. {ECO:0000250|UniProtKB:P10231}.
CC -!- DOMAIN: The nuclear export signal is CRM1-dependent.
CC {ECO:0000250|UniProtKB:P10231}.
CC -!- PTM: Monoubiquitinated. {ECO:0000269|PubMed:22542975}.
CC -!- PTM: Phosphorylated by US3. This phosphorylation is required for proper
CC nuclear localization. {ECO:0000250|UniProtKB:P10231}.
CC -!- MISCELLANEOUS: Expressed in late in the infection. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the alphaherpesvirinae HHV-1 UL47 family.
CC {ECO:0000305}.
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DR EMBL; Z54206; CAA90922.1; -; Genomic_DNA.
DR EMBL; M84469; AAA46064.1; -; Genomic_DNA.
DR EMBL; AJ004801; CAA06087.1; -; Genomic_DNA.
DR PIR; JQ1893; JQ1893.
DR RefSeq; NP_045312.1; NC_001847.1.
DR GeneID; 1487395; -.
DR KEGG; vg:1487395; -.
DR GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0019033; C:viral tegument; IEA:UniProtKB-SubCell.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR InterPro; IPR005029; Herpes_UL47.
DR Pfam; PF03362; Herpes_UL47; 1.
PE 1: Evidence at protein level;
KW Host cytoplasm; Host nucleus; Host-virus interaction; Late protein;
KW Transcription; Transcription regulation; Ubl conjugation; Virion;
KW Virion tegument.
FT CHAIN 1..739
FT /note="Tegument protein UL47"
FT /id="PRO_0000116075"
FT REGION 1..123
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 154..198
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 10..30
FT /note="Nuclear localization signal"
FT /evidence="ECO:0000255"
FT MOTIF 94..121
FT /note="Nuclear export signal"
FT /evidence="ECO:0000255"
FT MOTIF 483..493
FT /note="Nuclear export signal"
FT /evidence="ECO:0000255"
FT COMPBIAS 1..17
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 35..51
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 65..84
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 739 AA; 80757 MW; 8F81232DF08F3DDD CRC64;
MDAARDGRPE RRRAVSGTYR THPFQRPSAR RSAGRPARCG RRGRGAPRVR RPRPYFQRPP
DEDTSEDENV YDYIDGDSSD SADDYDSDYF TANRGPNHGA GDAMDTDAPP ERAPEGGAPQ
DYLTAHLRAI EVLPESAPHR SLLERTARTV YAQQFPPRDL SAGSKAPAQR ARRSLRGFPR
GGGGGQEPGP DDEGDDAADL REDLVPDEAY AHLERDERLS EGPPLLNMEA AAAAAGERSV
VEELFTYAPA QPQVEVPLPR ILEGRVRPSA FFAQMSLDAL CRTPPNDQRV ARERRAWEMA
GTPHGLLITT WSTVDPEFSI GGMYVGAPEG TRPRLVWRRA MKQAMALQYR LGVGGLCRAV
DGAACRPLRR CSFWRDALLR ECATAIFCRG RGARAAPRRL PRPAVGLLAA TQFTPPDASP
HATLFRGSMG SLIYWHELRV MLTAVPALCA RYAGAGLQSA ELYLLALRHS EAPGYTANER
YALSAYLTLF VALAERGLRW LYLAGAHLLG PHPTAAAFRE VRAKIPYERL PLGSATLHDA
EVETVDSATF QEALAFSALA HVYGEAYVAV RTATTLLMAE YAVHAERRDV RQMTAAFLGV
GLIAQRLMGS LNLLLNCVAG AAVYGGRRVT VREGTLARYS LLADAALPLV RPVFLVEFRE
ARDGVMRELR LRPVASPPLA GKRRVMELYL SLDSIEALVG REPLGSRPVL GPLVDIAEAL
ADHPHLVTGD GRGPRLGGR
