ID   TEG5_EHV1V              Reviewed;         871 AA.
AC   Q6S6Q8;
DT   15-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 48.
DE   RecName: Full=Tegument protein UL47 homolog;
DE   AltName: Full=GP10;
GN   OrderedLocusNames=13;
OS   Equine herpesvirus 1 (strain V592) (EHV-1) (Equine abortion virus).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Alphaherpesvirinae; Varicellovirus.
OX   NCBI_TaxID=310273;
OH   NCBI_TaxID=9796; Equus caballus (Horse).
RN   [1] {ECO:0000305, ECO:0000312|EMBL:AAS45897.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Davis-Poynter N., Nugent J., Birch-Machin I., Allen G.P.;
RL   Submitted (NOV-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Tegument protein that can bind to various RNA transcripts.
CC       Plays a role in the attenuation of selective viral and cellular mRNA
CC       degradation by modulating the activity of host shutoff RNase UL41/VHS.
CC       Also plays a role in the primary envelopement of virions in the
CC       perinuclear space, probably by interacting with two nuclear egress
CC       proteins UL31 and UL34. {ECO:0000250|UniProtKB:P10231}.
CC   -!- SUBUNIT: Interacts with US3 kinase. Interacts with UL31 and UL34; these
CC       interactions seem important for efficient virion nuclear egress.
CC       Interacts with UL41/VHS. {ECO:0000250|UniProtKB:P10231}.
CC   -!- SUBCELLULAR LOCATION: Virion tegument {ECO:0000250|UniProtKB:P10231}.
CC       Host nucleus {ECO:0000250|UniProtKB:P10231}. Host cytoplasm
CC       {ECO:0000250|UniProtKB:P10231}. Note=Major tegument protein of the
CC       virion. Undergoes nucleocytoplasmic shuttling during infection.
CC       Localizes to the major sites of transcription in the infected cell
CC       nucleus. {ECO:0000250|UniProtKB:P10231}.
CC   -!- DOMAIN: The nuclear export signal is CRM1-dependent.
CC       {ECO:0000250|UniProtKB:P10231}.
CC   -!- PTM: Phosphorylated by US3. This phosphorylation is required for proper
CC       nuclear localization. {ECO:0000250|UniProtKB:P10231}.
CC   -!- MISCELLANEOUS: Expressed in late in the infection. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the alphaherpesvirinae HHV-1 UL47 family.
CC       {ECO:0000305}.
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DR   EMBL; AY464052; AAS45897.1; -; Genomic_DNA.
DR   Proteomes; UP000008296; Genome.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0019033; C:viral tegument; IEA:UniProtKB-SubCell.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   InterPro; IPR005029; Herpes_UL47.
DR   Pfam; PF03362; Herpes_UL47; 1.
PE   3: Inferred from homology;
KW   Host cytoplasm; Host nucleus; Late protein; Transcription;
KW   Transcription regulation; Virion; Virion tegument.
FT   CHAIN           1..871
FT                   /note="Tegument protein UL47 homolog"
FT                   /id="PRO_0000116078"
FT   REGION          1..212
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           13..33
FT                   /note="Nuclear localization signal"
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        1..24
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        25..45
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        53..84
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        112..128
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        187..209
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   871 AA;  97027 MW;  637B22B42CF20DC9 CRC64;
     MDQHHGARGG APIRRPRRSI ESRSHPFRAT GNTQRTYSTP RLSYRDGLSG RTASRDPQEQ
     ASNQDESSNP STSNAQQSTS FWGYLRRVFS DDVPAQPQAP RPRADFAPPA GEESSSEEEE
     EEGPAQAPLD EEDQLMYADQ YSVGDSSDEN DEEEDPRLGS DYPTSAESSE YHDHGEMVAG
     AGAESESETD IDAEEEEEDD EDDEDDMEVI RDESYRLPRT WLDKSIRLMD EALAQSSELS
     KAITKSTRSL YDSQFAPGGR GYTQTATPSR RLVQLSRAGM YDSDKIVMTG DYMEVDDDPD
     SAYQLWVRAI RHPLAMNPSW EETISNHTNP SFSTDIDYDI DELIEKNLAR TPPVFEGLLD
     SAEFFYKLPM LYTYATITQD EAYEERLAWS NTQALHGHEQ SSWQALLVYY SRGGMYVSPT
     QEPRGIWRRA LKQAMALQLK MCVLGLSDVV TKQNATHHHT AVTFLVDALL RTARNCYLAS
     RLLVFAWERR RETGAKRPAE PLIALSGVTL LQPLPPEVSE LLEQRTFDIG LRTPNSAVFR
     AFFGSLVYWA ELRLALRDPA SINCRYVGFH LQTSEIYLLA RAHSASPGYT KEELVAMEAI
     LTLATLMLEV ALQWVHVACA QLLSENDTIK AFRRVSASIP HALAPLGSIR LHDAEFEVLS
     NPDVMVARDE TALSQALFLG YFSVRTALTA CMRDYSHEAD GGSKETVTGV FLGVGLILQR
     LAGHLNFLLN CLAGAALYGG QKINIHSLTL PRYSLLADVM APMLQRQSLV DFWRARDNML
     EDLEITPRPG PPTQGKRVVV EMPLPSDDLP DMTPGASVNN GAGLGRMVDM AKQLQHYRET
     IIGEEATSSV GKRGLIRAGV GVAALRGRRR K