ID   TEG5_PSHV1              Reviewed;         605 AA.
AC   Q6UDF9;
DT   05-APR-2011, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 42.
DE   RecName: Full=Tegument protein UL47 homolog;
GN   Name=sORF1;
OS   Psittacid herpesvirus 1 (isolate Amazon parrot/-/97-0001/1997) (PsHV-1)
OS   (Pacheco's disease virus).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Alphaherpesvirinae; Iltovirus.
OX   NCBI_TaxID=670426;
OH   NCBI_TaxID=152276; Amazona oratrix (yellow-headed parrot).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16873243; DOI=10.1128/jvi.00134-06;
RA   Thureen D.R., Keeler C.L. Jr.;
RT   "Psittacid herpesvirus 1 and infectious laryngotracheitis virus:
RT   Comparative genome sequence analysis of two avian alphaherpesviruses.";
RL   J. Virol. 80:7863-7872(2006).
CC   -!- FUNCTION: Tegument protein that can bind to various RNA transcripts.
CC       Plays a role in the attenuation of selective viral and cellular mRNA
CC       degradation by modulating the activity of host shutoff RNase UL41/VHS.
CC       Also plays a role in the primary envelopement of virions in the
CC       perinuclear space, probably by interacting with two nuclear egress
CC       proteins UL31 and UL34. {ECO:0000250|UniProtKB:P10231}.
CC   -!- SUBUNIT: Interacts with US3 kinase. Interacts with UL31 and UL34; these
CC       interactions seem important for efficient virion nuclear egress.
CC       Interacts with UL41/VHS. {ECO:0000250|UniProtKB:P10231}.
CC   -!- SUBCELLULAR LOCATION: Virion tegument {ECO:0000250|UniProtKB:P10231}.
CC       Host nucleus {ECO:0000250|UniProtKB:P10231}. Host cytoplasm
CC       {ECO:0000250|UniProtKB:P10231}. Note=Major tegument protein of the
CC       virion. Undergoes nucleocytoplasmic shuttling during infection.
CC       Localizes to the major sites of transcription in the infected cell
CC       nucleus. {ECO:0000250|UniProtKB:P10231}.
CC   -!- DOMAIN: The nuclear export signal is CRM1-dependent.
CC       {ECO:0000250|UniProtKB:P10231}.
CC   -!- PTM: Phosphorylated by US3. This phosphorylation is required for proper
CC       nuclear localization. {ECO:0000250|UniProtKB:P10231}.
CC   -!- SIMILARITY: Belongs to the alphaherpesvirinae HHV-1 UL47 family.
CC       {ECO:0000305}.
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DR   EMBL; AY372243; AAQ73751.1; -; Genomic_DNA.
DR   RefSeq; NP_944445.1; NC_005264.1.
DR   PRIDE; Q6UDF9; -.
DR   GeneID; 4237764; -.
DR   KEGG; vg:4237764; -.
DR   Proteomes; UP000006840; Genome.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0019033; C:viral tegument; IEA:UniProtKB-SubCell.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   InterPro; IPR005029; Herpes_UL47.
DR   Pfam; PF03362; Herpes_UL47; 1.
PE   3: Inferred from homology;
KW   Host cytoplasm; Host nucleus; Reference proteome; Virion; Virion tegument.
FT   CHAIN           1..605
FT                   /note="Tegument protein UL47 homolog"
FT                   /id="PRO_0000406851"
FT   REGION          1..75
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        55..69
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   605 AA;  66594 MW;  27793E4DC46F6E39 CRC64;
     MATDNARPRS RSLRRKSMGA EAALRDGAAQ PAAAHKTKVI ARSETGDDAD EDAGADRDPG
     TRRGIDPWKL EPANDPFASN KEYGGKWGAN GPADSAAKVL AAAWDIMALV DAEEVAKEQE
     TFEAKTSPVS PFGAWPGGQS WRTLGDYSHA PILYPSAEVI EADALKVGAY VSRVVQCSRF
     VADKKAQRPT VRSLQSFLEA AFWRVMQNAY STCLRLRPKL TAVSRSRRSG ANWRKPSPSD
     PNWYAVSNQF LWRGMRVPSL LLPPDVPIEE NAERGPTAAV FRNAGPALFI WPWARAPLDE
     RDKRLVRAAL WALDILDAAI LASFPYAWRP HVGDKQFEEA LDCLAEYFGL AVLLTETVLA
     ALLDHTLAFM KSLGAGNYDD FEEDRFADPG KNKYLMGVEG VSLTRLNSAG TALATVCANT
     YAALRCLPSV ATSSLTANYS AETRRARKPT REDLFSLLQH EALFYTIWLQ RMATHLDFCS
     NVLVESAKKG KQEFPIRRSA LVRHMWLQKL LSPLVVPVSL RDFAAAKKEA VADAKIETYV
     KSVQSTNKDP KGTIRFIASD NVKTLMASYE KYNPILDEPM IASRAFDDVI SGYGGRTAGG
     QNRGD