TEG5_VZVD
ID TEG5_VZVD Reviewed; 819 AA.
AC P09263;
DT 01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-1989, sequence version 1.
DT 03-AUG-2022, entry version 75.
DE RecName: Full=Tegument protein UL47 homolog;
GN ORFNames=ORF11;
OS Varicella-zoster virus (strain Dumas) (HHV-3) (Human herpesvirus 3).
OC Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC Herpesvirales; Herpesviridae; Alphaherpesvirinae; Varicellovirus.
OX NCBI_TaxID=10338;
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=3018124; DOI=10.1099/0022-1317-67-9-1759;
RA Davison A.J., Scott J.E.;
RT "The complete DNA sequence of varicella-zoster virus.";
RL J. Gen. Virol. 67:1759-1816(1986).
RN [2]
RP SUBCELLULAR LOCATION.
RX PubMed=17005680; DOI=10.1128/jvi.01322-06;
RA Verhagen J., Donnelly M., Elliott G.;
RT "Characterization of a novel transferable CRM-1-independent nuclear export
RT signal in a herpesvirus tegument protein that shuttles between the nucleus
RT and cytoplasm.";
RL J. Virol. 80:10021-10035(2006).
RN [3]
RP FUNCTION, AND SUBCELLULAR LOCATION.
RX PubMed=21276599; DOI=10.1016/j.virol.2010.12.055;
RA Che X., Oliver S.L., Sommer M.H., Rajamani J., Reichelt M., Arvin A.M.;
RT "Identification and functional characterization of the Varicella zoster
RT virus ORF11 gene product.";
RL Virology 412:156-166(2011).
RN [4]
RP INTERACTION WITH ORF9.
RX PubMed=23427162; DOI=10.1128/jvi.00102-13;
RA Che X., Oliver S.L., Reichelt M., Sommer M.H., Haas J., Rovis T.L.,
RA Arvin A.M.;
RT "ORF11 protein interacts with the ORF9 essential tegument protein in
RT varicella-zoster virus infection.";
RL J. Virol. 87:5106-5117(2013).
CC -!- FUNCTION: Tegument protein that can bind to various RNA transcripts.
CC Plays a role in the attenuation of selective viral and cellular mRNA
CC degradation by modulating the activity of host shutoff RNase ORF17/VHS.
CC Also plays a role in the primary envelopement of virions in the
CC perinuclear space, probably by interacting with two nuclear egress
CC proteins ORF24 and ORF27. {ECO:0000250|UniProtKB:P10231,
CC ECO:0000269|PubMed:21276599}.
CC -!- SUBUNIT: Interacts with US3 kinase. Interacts with ORF24 and ORF27;
CC these interactions seem important for efficient virion nuclear egress.
CC Interacts with ORF17/VHS. Interacts with ORF9.
CC {ECO:0000250|UniProtKB:P10231, ECO:0000269|PubMed:23427162}.
CC -!- SUBCELLULAR LOCATION: Virion tegument {ECO:0000269|PubMed:21276599}.
CC Host nucleus {ECO:0000269|PubMed:21276599}. Host cytoplasm
CC {ECO:0000269|PubMed:21276599}. Note=Major tegument protein of the
CC virion. Undergoes nucleocytoplasmic shuttling during infection.
CC Localizes to the major sites of transcription in the infected cell
CC nucleus. {ECO:0000250|UniProtKB:P10231}.
CC -!- DOMAIN: The nuclear export signal is CRM1-dependent.
CC {ECO:0000250|UniProtKB:P10231}.
CC -!- PTM: Phosphorylated by US3. This phosphorylation is required for proper
CC nuclear localization. {ECO:0000250|UniProtKB:P10231}.
CC -!- MISCELLANEOUS: Expressed in late in the infection. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the alphaherpesvirinae HHV-1 UL47 family.
CC {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; X04370; CAA27894.1; -; Genomic_DNA.
DR PIR; B27342; TNBE11.
DR PRIDE; P09263; -.
DR Proteomes; UP000002602; Genome.
DR GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0019033; C:viral tegument; IEA:UniProtKB-SubCell.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR InterPro; IPR005029; Herpes_UL47.
DR Pfam; PF03362; Herpes_UL47; 1.
PE 1: Evidence at protein level;
KW Host cytoplasm; Host nucleus; Late protein; Reference proteome; Repeat;
KW RNA-binding; Transcription; Transcription regulation; Virion;
KW Virion tegument.
FT CHAIN 1..819
FT /note="Tegument protein UL47 homolog"
FT /id="PRO_0000116080"
FT REPEAT 117..132
FT /note="1-1"
FT REPEAT 133..148
FT /note="1-2"
FT REPEAT 149..164
FT /note="1-3"
FT REPEAT 165..190
FT /note="1-4"
FT REPEAT 191..206
FT /note="1-5"
FT REPEAT 207..218
FT /note="1-6; truncated"
FT REGION 1..42
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 58..221
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 117..218
FT /note="6 X 16 AA approximate tandem repeats"
FT MOTIF 11..31
FT /note="Nuclear localization signal"
FT /evidence="ECO:0000255"
FT MOTIF 785..807
FT /note="Nuclear export signal"
FT /evidence="ECO:0000250"
FT COMPBIAS 82..97
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 98..113
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 114..218
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 819 AA; 91830 MW; 1814DA0D5493B8C8 CRC64;
MQSGHYNRRQ SRRQRISSNT TDSPRHTHGT RYRSTNWYTH PPQILSNSET LVAVQELLNS
EMDQDSSSDA SDDFPGYALH HSTYNGSEQN TSTSRHENRI FKLTEREANE EININTDAID
DEGEAEEGEA EEDAIDDEGE AEEGEAEEDA IDDEGEAEEG EAEEDAIDDE GEAEEGEAEE
GEAEEGEAEE DAIDDEGEAE EDAAEEDAID DEGEAEEDYF SVSQVCSRDA DEVYFTLDPE
ISYSTDLRIA KVMEPAVSKE LNVSKRCVEP VTLTGSMLAH NGFDESWFAM RECTRREYIT
VQGLYDPIHL RYQFDTSRMT PPQILRTIPA LPNMTLGELL LIFPIEFMAQ PISIERILVE
DVFLDRRASS KTHKYGPRWN SVYALPYNAG KMYVQHIPGF YDVSLRAVGQ GTAIWHHMIL
STAACAISNR ISHGDGLGFL LDAAIRISAN CIFLGRNDNF GVGDPCWLED HLAGLPREAV
PDVLQVTQLV LPNRGPTVAI MRGFFGALAY WPELRIAISE PSTSLVRYAT GHMELAEWFL
FSRTHSLKPQ FTPTEREMLA SFFTLYVTLG GGMLNWICRA TAMYLAAPYH SRSAYIAVCE
SLPYYYIPVN SDLLCDLEVL LLGEVDLPTV CESYATIAHE LTGYEAVRTA ATNFMIEFAD
CYKESETDLM VSAYLGAVLL LQRVLGHANL LLLLLSGAAL YGGCSIYIPR GILDAYNTLM
LAASPLYAHQ TLTSFWKDRD DAMQTLGIRP TTDVLPKEQD RIVQASPIEM NFRFVGLETI
YPREQPIPSV DLAENLMQYR NEILGLDWKS VAMHLLRKY
