TEG5_VZVO
ID TEG5_VZVO Reviewed; 804 AA.
AC Q4JQW4;
DT 22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT 02-AUG-2005, sequence version 1.
DT 03-AUG-2022, entry version 45.
DE RecName: Full=Tegument protein UL47 homolog;
GN ORFNames=ORF11;
OS Varicella-zoster virus (strain Oka vaccine) (HHV-3) (Human herpesvirus 3).
OC Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC Herpesvirales; Herpesviridae; Alphaherpesvirinae; Varicellovirus.
OX NCBI_TaxID=341980;
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate Human/Japan/P-Oka/1970, and
RC Oka varicella vaccine Biken (V-Oka-Biken);
RX PubMed=12388706; DOI=10.1128/jvi.76.22.11447-11459.2002;
RA Gomi Y., Sunamachi H., Mori Y., Nagaike K., Takahashi M., Yamanishi K.;
RT "Comparison of the complete DNA sequences of the Oka varicella vaccine and
RT its parental virus.";
RL J. Virol. 76:11447-11459(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Oka varicella vaccine VarilRix (V-Oka-GSK), and
RC Oka varicella vaccine Varivax (V-Oka-Merk);
RX PubMed=18787000; DOI=10.1128/jvi.00777-08;
RA Tillieux S.L., Halsey W.S., Thomas E.S., Voycik J.J., Sathe G.M.,
RA Vassilev V.;
RT "Complete DNA sequences of two oka strain varicella-zoster virus genomes.";
RL J. Virol. 82:11023-11044(2008).
CC -!- FUNCTION: Tegument protein that can bind to various RNA transcripts.
CC Plays a role in the attenuation of selective viral and cellular mRNA
CC degradation by modulating the activity of host shutoff RNase ORF17/VHS.
CC Also plays a role in the primary envelopement of virions in the
CC perinuclear space, probably by interacting with two nuclear egress
CC proteins ORF24 and ORF27. {ECO:0000250|UniProtKB:P10231}.
CC -!- SUBUNIT: Interacts with US3 kinase. Interacts with ORF24 and ORF27;
CC these interactions seem important for efficient virion nuclear egress.
CC Interacts with ORF17/VHS. {ECO:0000250|UniProtKB:P10231}.
CC -!- SUBCELLULAR LOCATION: Virion tegument {ECO:0000250|UniProtKB:P10231}.
CC Host nucleus {ECO:0000250|UniProtKB:P10231}. Host cytoplasm
CC {ECO:0000250|UniProtKB:P10231}. Note=Major tegument protein of the
CC virion. Undergoes nucleocytoplasmic shuttling during infection.
CC Localizes to the major sites of transcription in the infected cell
CC nucleus. {ECO:0000250|UniProtKB:P10231}.
CC -!- DOMAIN: The nuclear export signal is CRM1-dependent.
CC {ECO:0000250|UniProtKB:P10231}.
CC -!- PTM: Phosphorylated by US3. This phosphorylation is required for proper
CC nuclear localization. {ECO:0000250|UniProtKB:P10231}.
CC -!- MISCELLANEOUS: Expressed in late in the infection. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the alphaherpesvirinae HHV-1 UL47 family.
CC {ECO:0000305}.
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DR EMBL; AB097932; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AB097933; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DQ008354; AAY57629.1; -; Genomic_DNA.
DR EMBL; DQ008355; AAY57700.1; -; Genomic_DNA.
DR IntAct; Q4JQW4; 5.
DR MINT; Q4JQW4; -.
DR Proteomes; UP000002603; Genome.
DR Proteomes; UP000008504; Genome.
DR Proteomes; UP000008505; Genome.
DR Proteomes; UP000008506; Genome.
DR GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0019033; C:viral tegument; IEA:UniProtKB-SubCell.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR InterPro; IPR005029; Herpes_UL47.
DR Pfam; PF03362; Herpes_UL47; 1.
PE 3: Inferred from homology;
KW Host cytoplasm; Host nucleus; Late protein; Repeat; RNA-binding;
KW Transcription; Transcription regulation; Virion; Virion tegument.
FT CHAIN 1..804
FT /note="Tegument protein UL47 homolog"
FT /id="PRO_0000385494"
FT REPEAT 117..132
FT /note="1-1"
FT REPEAT 133..148
FT /note="1-2"
FT REPEAT 149..164
FT /note="1-3"
FT REPEAT 170..180
FT /note="1-4; truncated"
FT REPEAT 181..191
FT /note="1-5; truncated"
FT REPEAT 192..203
FT /note="1-6; truncated"
FT REGION 1..42
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 58..206
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 117..203
FT /note="6 X 16 AA approximate tandem repeats"
FT MOTIF 11..31
FT /note="Nuclear localization signal"
FT /evidence="ECO:0000255"
FT MOTIF 770..792
FT /note="Nuclear export signal"
FT /evidence="ECO:0000250"
FT COMPBIAS 82..97
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 98..113
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 114..203
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 177..187
FT /note="Missing (in strain: Isolate Human/Japan/P-Oka/1970)"
SQ SEQUENCE 804 AA; 90284 MW; 71757471DBE4F915 CRC64;
MQSGHYNRRQ SRRQRISSNT TDSPRHTHGT RYRSTNWYTH PPQILSNSET LVAVQELLNS
EMDQDSSSDA SDDFPGYALH HSTYNGSEQN TSTSRHENRI FKLTEREANE EININTDAID
DEGEAEEGEA EEDAIDDEGE AEEGEAEEDA IDDEGEAEEG EAEEDAAEED AIDDEGEAEE
DAIDDEGEAE EDAIDDEGEA EEDYFSVSQV CSRDADEVYF TLDPEISYST DLRIAKVMEP
AVSKELNVSK RCVEPVTLTG SMLAHNGFDE SWFAMRECTR REYITVQGLY DPIHLRYQFD
TSRMTPPQIL RTIPALPNMT LGELLLIFPI EFMAQPISIE RILVEDVFLD RRASSKTHKY
GPRWNSVYAL PYNAGKMYVQ HIPGFYDVSL RAVGQGTAIW HHMILSTAAC AISNRISHGD
GLGFLLDAAI RISANCIFLG RNDNFGVGDP CWLEDHLAGL PREAVPDVLQ VTQLVLPNRG
PTVAIMRGFF GALAYWPELR IAISEPSTSL VRYATGHMEL AEWFLFSRTH SLKPQFTPTE
REMLASFFTL YVTLGGGMLN WICRATAMYL AAPYHSRSAY IAVCESLPYY YIPVNSDLLC
DLEVLLLGEV DLPTVCESYA TIAHELTGYE AVRTAATNFM IEFADCYKES ETDLMVSAYL
GAVLLLQRVL GHANLLLLLL SGAALYGGCS IYIPRGILDA YNTLMLAASP LYAHQTLTSF
WKDRDDAMQT LGIRPTTDVL PKEQDRIVQA SPIEMNFRFV GLETIYPREQ PIPSVDLAEN
LMQYRNEILG LDWKSVAMHL LRKY
