TEG7_HCMVA
ID TEG7_HCMVA Reviewed; 361 AA.
AC P16823; Q7M6M1;
DT 01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
DT 15-FEB-2005, sequence version 2.
DT 02-JUN-2021, entry version 60.
DE RecName: Full=Tegument protein UL51 homolog;
GN Name=UL71;
OS Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5).
OC Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC Herpesvirales; Herpesviridae; Betaherpesvirinae; Cytomegalovirus.
OX NCBI_TaxID=10360;
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=2161319; DOI=10.1007/978-3-642-74980-3_6;
RA Chee M.S., Bankier A.T., Beck S., Bohni R., Brown C.M., Cerny R.,
RA Horsnell T., Hutchison C.A. III, Kouzarides T., Martignetti J.A.,
RA Preddie E., Satchwell S.C., Tomlinson P., Weston K.M., Barrell B.G.;
RT "Analysis of the protein-coding content of the sequence of human
RT cytomegalovirus strain AD169.";
RL Curr. Top. Microbiol. Immunol. 154:125-169(1990).
RN [2]
RP GENOME REANNOTATION.
RX PubMed=12533697; DOI=10.1099/vir.0.18606-0;
RA Davison A.J., Dolan A., Akter P., Addison C., Dargan D.J., Alcendor D.J.,
RA McGeoch D.J., Hayward G.S.;
RT "The human cytomegalovirus genome revisited: comparison with the chimpanzee
RT cytomegalovirus genome.";
RL J. Gen. Virol. 84:17-28(2003).
RN [3]
RP ERRATUM OF PUBMED:12533697.
RA Davison A.J., Dolan A., Akter P., Addison C., Dargan D.J., Alcendor D.J.,
RA McGeoch D.J., Hayward G.S.;
RL J. Gen. Virol. 84:1053-1053(2003).
RN [4]
RP IDENTIFICATION.
RX PubMed=15452216; DOI=10.1128/jvi.78.20.10960-10966.2004;
RA Varnum S.M., Streblow D.N., Monroe M.E., Smith P., Auberry K.J.,
RA Pasa-Tolic L., Wang D., Camp D.G. II, Rodland K., Wiley S., Britt W.,
RA Shenk T., Smith R.D., Nelson J.A.;
RT "Identification of proteins in human cytomegalovirus (HCMV) particles: the
RT HCMV proteome.";
RL J. Virol. 78:10960-10966(2004).
RN [5]
RP ERRATUM OF PUBMED:15452216.
RA Varnum S.M., Streblow D.N., Monroe M.E., Smith P., Auberry K.J.,
RA Pasa-Tolic L., Wang D., Camp D.G. II, Rodland K., Wiley S., Britt W.,
RA Shenk T., Smith R.D., Nelson J.A.;
RL J. Virol. 78:13395-13395(2004).
RN [6]
RP FUNCTION.
RX PubMed=21289123; DOI=10.1128/jvi.01540-10;
RA Schauflinger M., Fischer D., Schreiber A., Chevillotte M., Walther P.,
RA Mertens T., von Einem J.;
RT "The tegument protein UL71 of human cytomegalovirus is involved in late
RT envelopment and affects multivesicular bodies.";
RL J. Virol. 85:3821-3832(2011).
RN [7]
RP OLIGOMERIZATION, MUTAGENESIS OF LEU-34 AND LEU-41, AND SUBCELLULAR
RP LOCATION.
RX PubMed=22205740; DOI=10.1128/jvi.06556-11;
RA Meissner C.S., Suffner S., Schauflinger M., von Einem J., Bogner E.;
RT "A leucine zipper motif of a tegument protein triggers final envelopment of
RT human cytomegalovirus.";
RL J. Virol. 86:3370-3382(2012).
CC -!- FUNCTION: Plays several roles during the time course of infection,
CC including egress of virus particles from the perinuclear space and
CC secondary envelopment of cytoplasmic capsids that bud into specific
CC trans-Golgi network (TGN)-derived membranes.
CC {ECO:0000250|UniProtKB:P10235, ECO:0000269|PubMed:21289123}.
CC -!- SUBUNIT: Oligomerizes. Interacts with UL103; this interaction mediates
CC UL103 incorporation to virions. {ECO:0000250|UniProtKB:P10235,
CC ECO:0000269|PubMed:22205740}.
CC -!- SUBCELLULAR LOCATION: Virion tegument {ECO:0000250|UniProtKB:P10235}.
CC Host cytoplasm {ECO:0000250|UniProtKB:P10235}. Host Golgi apparatus
CC {ECO:0000250|UniProtKB:P10235}.
CC -!- PTM: Phosphorylated. {ECO:0000250|UniProtKB:P10235}.
CC -!- PTM: Palmitoylation is necessary for Golgi localization.
CC {ECO:0000250|UniProtKB:P10235}.
CC -!- SIMILARITY: Belongs to the herpesviridae UL51 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAA35385.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; X17403; CAA35385.1; ALT_INIT; Genomic_DNA.
DR EMBL; BK000394; DAA00167.1; -; Genomic_DNA.
DR PIR; S09833; S09833.
DR Proteomes; UP000008991; Genome.
DR Proteomes; UP000008992; Genome.
DR GO; GO:0044177; C:host cell Golgi apparatus; IEA:UniProtKB-SubCell.
DR GO; GO:0019033; C:viral tegument; IEA:UniProtKB-SubCell.
DR InterPro; IPR007619; Herpes_U44.
DR Pfam; PF04533; Herpes_U44; 1.
PE 1: Evidence at protein level;
KW Host cytoplasm; Host Golgi apparatus; Lipoprotein; Palmitate;
KW Phosphoprotein; Reference proteome; Virion; Virion tegument.
FT CHAIN 1..361
FT /note="Tegument protein UL51 homolog"
FT /id="PRO_0000116214"
FT REGION 251..299
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 285..299
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT LIPID 8
FT /note="S-palmitoyl cysteine; by host"
FT /evidence="ECO:0000250|UniProtKB:P10235"
FT MUTAGEN 34
FT /note="L->A: Complete loss of oligomerization."
FT /evidence="ECO:0000269|PubMed:22205740"
FT MUTAGEN 41
FT /note="L->A: Complete loss of oligomerization."
FT /evidence="ECO:0000269|PubMed:22205740"
SQ SEQUENCE 361 AA; 39886 MW; 75A4F0730C6981AF CRC64;
MQLAQRLCEL LMCRRKAAPV ADYVLLQPSE DVELRELQAF LDENFKQLEI TPADLRTFSR
DTDVVNHLLK LLPLYRQCQS KCAFLKGYLS EGCLPHTRPA AEVECKKSQR ILEALDILIL
KLVVGEFAMS EADSLEMLLD KFSTDQASLV EVQRVMGLVD MDCEKSAYML EAGAAATVAP
LTPPAVVQGE SGVREDGETV AAVSAFACPS VSDSLIPEET GVTRPMMSLA HINTVSCPTV
MRFDQRLLEE GDEEDEVTVM SPSPEPVQQQ PPVEPVQQQP QGRGSHRRRY KESAPQETLP
TNHEREILDL MRHSPDVPRE AVMSPTMVTI PPPQIPFVGS ARELRGVKKK KPTAAALLSS
A
