ID   TEG7_HCMVM              Reviewed;         361 AA.
AC   F5HEA3;
DT   13-JUN-2012, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 1.
DT   29-SEP-2021, entry version 22.
DE   RecName: Full=Tegument protein UL51 homolog;
GN   Name=UL71;
OS   Human cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Betaherpesvirinae; Cytomegalovirus.
OX   NCBI_TaxID=295027;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15105547; DOI=10.1099/vir.0.79888-0;
RA   Dolan A., Cunningham C., Hector R.D., Hassan-Walker A.F., Lee L.,
RA   Addison C., Dargan D.J., McGeoch D.J., Gatherer D., Emery V.C.,
RA   Griffiths P.D., Sinzger C., McSharry B.P., Wilkinson G.W.G., Davison A.J.;
RT   "Genetic content of wild-type human cytomegalovirus.";
RL   J. Gen. Virol. 85:1301-1312(2004).
CC   -!- FUNCTION: Plays several roles during the time course of infection,
CC       including egress of virus particles from the perinuclear space and
CC       secondary envelopment of cytoplasmic capsids that bud into specific
CC       trans-Golgi network (TGN)-derived membranes.
CC       {ECO:0000250|UniProtKB:P10235}.
CC   -!- SUBUNIT: Oligomerizes. Interacts with UL103; this interaction mediates
CC       UL103 incorporation to virions. {ECO:0000250|UniProtKB:P10235,
CC       ECO:0000250|UniProtKB:P16823}.
CC   -!- SUBCELLULAR LOCATION: Virion tegument {ECO:0000250|UniProtKB:P10235}.
CC       Host cytoplasm {ECO:0000250|UniProtKB:P10235}. Host Golgi apparatus
CC       {ECO:0000250|UniProtKB:P10235}.
CC   -!- PTM: Phosphorylated. {ECO:0000250|UniProtKB:P10235}.
CC   -!- PTM: Palmitoylation is necessary for Golgi localization.
CC       {ECO:0000250|UniProtKB:P10235}.
CC   -!- SIMILARITY: Belongs to the herpesviridae UL51 family. {ECO:0000305}.
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DR   EMBL; AY446894; AAR31724.1; -; Genomic_DNA.
DR   RefSeq; YP_081519.1; NC_006273.2.
DR   PRIDE; F5HEA3; -.
DR   DNASU; 3077537; -.
DR   GeneID; 3077537; -.
DR   KEGG; vg:3077537; -.
DR   Reactome; R-HSA-9609690; HCMV Early Events.
DR   Reactome; R-HSA-9610379; HCMV Late Events.
DR   Proteomes; UP000000938; Genome.
DR   GO; GO:0044177; C:host cell Golgi apparatus; IEA:UniProtKB-SubCell.
DR   GO; GO:0072517; C:host cell viral assembly compartment; TAS:Reactome.
DR   GO; GO:0019033; C:viral tegument; TAS:Reactome.
DR   InterPro; IPR007619; Herpes_U44.
DR   Pfam; PF04533; Herpes_U44; 1.
PE   3: Inferred from homology;
KW   Host cytoplasm; Host Golgi apparatus; Lipoprotein; Palmitate;
KW   Phosphoprotein; Reference proteome; Virion; Virion tegument.
FT   CHAIN           1..361
FT                   /note="Tegument protein UL51 homolog"
FT                   /id="PRO_0000417846"
FT   REGION          251..299
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        285..299
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   LIPID           8
FT                   /note="S-palmitoyl cysteine; by host"
FT                   /evidence="ECO:0000250|UniProtKB:P10235"
SQ   SEQUENCE   361 AA;  39860 MW;  27E5EF8F36298BD6 CRC64;
     MQLAQRLCEL LMCRRKAAPV ADYVLLQPSE DVELRELQAF LDENFKQLEI TPADLRTFSR
     DTDVVNHLLK LLPLYRQCQS KCAFLKGYLS EGCLPHTRPA AEVECKKSQR ILEALDILIL
     KLVVGEFAMS EADSLEMLLD KFSTDQASLV EVQRVMGLVD MDCEKSAYML EAGAAATVAP
     PTPPAVVQGE SGVREDGETV AAVSAFACSS VSDSLIPEET GVTRPMMSLA HINTVSCPTV
     MRFDQRLLEE GDEEDEVTVM SPSPEPVQQQ PPVEPVQQQP QGRGSHRRRY KESAPQETLP
     TNHEREILDL MRHSPDVPRE AVMSPTMVTI PPPQIPFVGS ARELRGVKKK KPTAAALLSS
     A