ID   TEG7_HHV11              Reviewed;         244 AA.
AC   P10235; Q09I83;
DT   01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1989, sequence version 1.
DT   02-JUN-2021, entry version 74.
DE   RecName: Full=Tegument protein UL51;
GN   ORFNames=UL51;
OS   Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Alphaherpesvirinae; Simplexvirus.
OX   NCBI_TaxID=10299;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=2839594; DOI=10.1099/0022-1317-69-7-1531;
RA   McGeoch D.J., Dalrymple M.A., Davison A.J., Dolan A., Frame M.C., McNab D.,
RA   Perry L.J., Scott J.E., Taylor P.;
RT   "The complete DNA sequence of the long unique region in the genome of
RT   herpes simplex virus type 1.";
RL   J. Gen. Virol. 69:1531-1574(1988).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Nonneuroinvasive mutant HF10;
RX   PubMed=17218138; DOI=10.1016/j.micinf.2006.10.019;
RA   Ushijima Y., Luo C., Goshima F., Yamauchi Y., Kimura H., Nishiyama Y.;
RT   "Determination and analysis of the DNA sequence of highly attenuated herpes
RT   simplex virus type 1 mutant HF10, a potential oncolytic virus.";
RL   Microbes Infect. 9:142-149(2007).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=17 syn+;
RA   Cunningham C., Davison A.J.;
RT   "Herpes simplex virus type 1 bacterial artificial chromosome.";
RL   Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-68.
RX   PubMed=2826807; DOI=10.1128/jvi.62.2.444-453.1988;
RA   McGeoch D.J., Dalrymple M.A., Dolan A., McNab D., Perry L.J., Taylor P.,
RA   Challberg M.D.;
RT   "Structures of herpes simplex virus type 1 genes required for replication
RT   of virus DNA.";
RL   J. Virol. 62:444-453(1988).
RN   [5]
RP   PHOSPHORYLATION.
RX   PubMed=9880018; DOI=10.1099/0022-1317-79-12-3027;
RA   Daikoku T., Ikenoya K., Yamada H., Goshima F., Nishiyama Y.;
RT   "Identification and characterization of the herpes simplex virus type 1
RT   UL51 gene product.";
RL   J. Gen. Virol. 79:3027-3031(1998).
RN   [6]
RP   SUBCELLULAR LOCATION, AND PALMITOYLATION AT CYS-9.
RC   STRAIN=KOS;
RX   PubMed=12584344; DOI=10.1128/jvi.77.5.3204-3216.2003;
RA   Nozawa N., Daikoku T., Koshizuka T., Yamauchi Y., Yoshikawa T.,
RA   Nishiyama Y.;
RT   "Subcellular localization of herpes simplex virus type 1 UL51 protein and
RT   role of palmitoylation in Golgi apparatus targeting.";
RL   J. Virol. 77:3204-3216(2003).
RN   [7]
RP   FUNCTION.
RX   PubMed=15890934; DOI=10.1128/jvi.79.11.6947-6956.2005;
RA   Nozawa N., Kawaguchi Y., Tanaka M., Kato A., Kato A., Kimura H.,
RA   Nishiyama Y.;
RT   "Herpes simplex virus type 1 UL51 protein is involved in maturation and
RT   egress of virus particles.";
RL   J. Virol. 79:6947-6956(2005).
RN   [8]
RP   SUBCELLULAR LOCATION.
RC   STRAIN=F;
RX   PubMed=18596102; DOI=10.1128/jvi.00904-08;
RA   Loret S., Guay G., Lippe R.;
RT   "Comprehensive characterization of extracellular herpes simplex virus type
RT   1 virions.";
RL   J. Virol. 82:8605-8618(2008).
RN   [9]
RP   INTERACTION WITH UL7, AND SUBCELLULAR LOCATION.
RX   PubMed=25552711; DOI=10.1128/jvi.02799-14;
RA   Roller R.J., Fetters R.;
RT   "The HSV-1 UL51 protein interacts with the UL7 protein and plays a role in
RT   its recruitment into the virion.";
RL   J. Virol. 89:3112-3122(2015).
RN   [10]
RP   INTERACTION WITH UL14.
RX   PubMed=27440890; DOI=10.1128/jvi.01258-16;
RA   Oda S., Arii J., Koyanagi N., Kato A., Kawaguchi Y.;
RT   "The interaction between Herpes Simplex Virus 1 tegument proteins UL51 and
RT   UL14 and its role in virion morphogenesis.";
RL   J. Virol. 90:8754-8767(2016).
RN   [11]
RP   FUNCTION, SUBCELLULAR LOCATION, AND MUTAGENESIS OF TYR-19.
RX   PubMed=32699089; DOI=10.1128/jvi.00900-20;
RA   White S., Kawano H., Harata N.C., Roller R.J.;
RT   "Herpes Simplex Virus Organizes Cytoplasmic Membranes To Form a Viral
RT   Assembly Center in Neuronal Cells.";
RL   J. Virol. 94:0-0(2020).
CC   -!- FUNCTION: Plays several roles during the time course of infection,
CC       including egress of virus particles from the perinuclear space and
CC       secondary envelopment of cytoplasmic capsids that bud into specific
CC       trans-Golgi network (TGN)-derived membranes (PubMed:15890934). Plays
CC       also an essential role in the maintenance of host cytoplasmic viral
CC       assembly center (cVAC) morphology in primary host neuronal cells
CC       (PubMed:32699089). {ECO:0000269|PubMed:15890934,
CC       ECO:0000269|PubMed:32699089}.
CC   -!- SUBUNIT: Oligomerizes. Interacts with UL7; this interaction mediates
CC       UL7 incorporation to virions. Interacts with UL14 (PubMed:27440890).
CC       {ECO:0000250|UniProtKB:P16823, ECO:0000269|PubMed:25552711,
CC       ECO:0000269|PubMed:27440890}.
CC   -!- SUBCELLULAR LOCATION: Virion tegument {ECO:0000269|PubMed:18596102,
CC       ECO:0000269|PubMed:32699089}. Host cytoplasm
CC       {ECO:0000269|PubMed:12584344, ECO:0000269|PubMed:32699089}. Host Golgi
CC       apparatus {ECO:0000269|PubMed:12584344}. Note=Localizes to cytoplasmic
CC       viral assembly center (cVAC) where capsid envelopment occurs.
CC       {ECO:0000269|PubMed:32699089}.
CC   -!- PTM: Phosphorylated. {ECO:0000269|PubMed:9880018}.
CC   -!- PTM: Palmitoylation is necessary for Golgi localization.
CC       {ECO:0000269|PubMed:12584344}.
CC   -!- SIMILARITY: Belongs to the herpesviridae UL51 family. {ECO:0000305}.
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DR   EMBL; X14112; CAA32302.1; -; Genomic_DNA.
DR   EMBL; M19122; AAA45825.2; -; Genomic_DNA.
DR   EMBL; DQ889502; ABI63512.1; -; Genomic_DNA.
DR   EMBL; FJ593289; ACM62275.1; -; Genomic_DNA.
DR   PIR; F30089; WMBEY1.
DR   RefSeq; YP_009137127.1; NC_001806.2.
DR   SMR; P10235; -.
DR   BioGRID; 971448; 1.
DR   iPTMnet; P10235; -.
DR   PRIDE; P10235; -.
DR   DNASU; 2703422; -.
DR   GeneID; 2703422; -.
DR   KEGG; vg:2703422; -.
DR   Proteomes; UP000009294; Genome.
DR   Proteomes; UP000180652; Genome.
DR   GO; GO:0044177; C:host cell Golgi apparatus; IEA:UniProtKB-SubCell.
DR   GO; GO:0019033; C:viral tegument; IEA:UniProtKB-SubCell.
DR   InterPro; IPR007625; Herpes_UL51.
DR   Pfam; PF04540; Herpes_UL51; 1.
PE   1: Evidence at protein level;
KW   Host cytoplasm; Host Golgi apparatus; Lipoprotein; Palmitate;
KW   Phosphoprotein; Reference proteome; Virion; Virion tegument.
FT   CHAIN           1..244
FT                   /note="Tegument protein UL51"
FT                   /id="PRO_0000116099"
FT   REGION          178..244
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   LIPID           9
FT                   /note="S-palmitoyl cysteine; by host"
FT                   /evidence="ECO:0000269|PubMed:12584344"
FT   VARIANT         92
FT                   /note="F -> L (in strain: Nonneuroinvasive mutant HF10 and
FT                   17 syn+)"
FT   MUTAGEN         19
FT                   /note="Y->A: Loss of cytoplasmic viral assembly center
FT                   maintenance."
FT                   /evidence="ECO:0000269|PubMed:32699089"
SQ   SEQUENCE   244 AA;  25470 MW;  F50054D6613F1897 CRC64;
     MASLLGAICG WGARPEEQYE MIRAAVPPSE AEPRLQEALA VVNALLPAPI TLDDALGSLD
     DTRRLVKARA LARTYHACMV NLERLARHHP GFEAPTIDGA VAAHQDKMRR LADTCMATIL
     QMYMSVGAAD KSADVLVSQA IRSMAESDVV MEDVAIAERA LGLSAFGVAG GTRSGGIGVT
     EAPSLGHPHT PPPEVTLAPA ARNGDALPDP KPESCPRVSV PRPTASPTAP RPGPSRAAPC
     VLGQ