ID   TEG7_HHV2H              Reviewed;         244 AA.
AC   P89470;
DT   22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1997, sequence version 1.
DT   02-JUN-2021, entry version 53.
DE   RecName: Full=Tegument protein UL51;
GN   ORFNames=UL51;
OS   Human herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Alphaherpesvirinae; Simplexvirus.
OX   NCBI_TaxID=10315;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=9499055; DOI=10.1128/jvi.72.3.2010-2021.1998;
RA   Dolan A., Jamieson F.E., Cunningham C., Barnett B.C., McGeoch D.J.;
RT   "The genome sequence of herpes simplex virus type 2.";
RL   J. Virol. 72:2010-2021(1998).
CC   -!- FUNCTION: Plays several roles during the time course of infection,
CC       including egress of virus particles from the perinuclear space and
CC       secondary envelopment of cytoplasmic capsids that bud into specific
CC       trans-Golgi network (TGN)-derived membranes.
CC       {ECO:0000250|UniProtKB:P10235}.
CC   -!- SUBUNIT: Oligomerizes. Interacts with UL7; this interaction mediates
CC       UL7 incorporation to virions. {ECO:0000250|UniProtKB:P10235,
CC       ECO:0000250|UniProtKB:P16823}.
CC   -!- SUBCELLULAR LOCATION: Virion tegument {ECO:0000250|UniProtKB:P10235}.
CC       Host cytoplasm {ECO:0000250|UniProtKB:P10235}. Host Golgi apparatus
CC       {ECO:0000250|UniProtKB:P10235}.
CC   -!- PTM: Phosphorylated. {ECO:0000250|UniProtKB:P10235}.
CC   -!- PTM: Palmitoylation is necessary for Golgi localization.
CC       {ECO:0000250|UniProtKB:P10235}.
CC   -!- SIMILARITY: Belongs to the herpesviridae UL51 family. {ECO:0000305}.
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DR   EMBL; Z86099; CAB06738.1; -; Genomic_DNA.
DR   RefSeq; YP_009137204.1; NC_001798.2.
DR   SMR; P89470; -.
DR   PRIDE; P89470; -.
DR   DNASU; 1487340; -.
DR   GeneID; 1487340; -.
DR   KEGG; vg:1487340; -.
DR   Proteomes; UP000001874; Genome.
DR   GO; GO:0044177; C:host cell Golgi apparatus; IEA:UniProtKB-SubCell.
DR   GO; GO:0019033; C:viral tegument; IEA:UniProtKB-SubCell.
DR   InterPro; IPR007625; Herpes_UL51.
DR   Pfam; PF04540; Herpes_UL51; 1.
PE   3: Inferred from homology;
KW   Host cytoplasm; Host Golgi apparatus; Lipoprotein; Palmitate;
KW   Phosphoprotein; Reference proteome; Virion; Virion tegument.
FT   CHAIN           1..244
FT                   /note="Tegument protein UL51"
FT                   /id="PRO_0000385157"
FT   REGION          175..244
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        209..223
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   LIPID           9
FT                   /note="S-palmitoyl cysteine; by host"
FT                   /evidence="ECO:0000250|UniProtKB:P10235"
SQ   SEQUENCE   244 AA;  25654 MW;  8FAEED5D6730511A CRC64;
     MASLLGVLCG WGTRPEEQQY EMIRAAAPPS EAEPRLQEAL AVVNALLPAP ITLDDALESL
     DDTRRLVKAR ALARTYHACM VNLERLARHH PGLEGSTIDG AVAAHRDKMR RLADTCMATI
     LQMYMSVGAA DKSADVLVSQ AIRSMAESDV VMEDVAIAER ALGLSTSALA GGTRTAGLGA
     TEAPPGPTRA QAPEVASVPV THAGDRSPVR PGPVPPADPT PDPRHRTSAP KRQASSTEAP
     LLLA