ID   TEG7_HHV7J              Reviewed;         203 AA.
AC   P52474;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   23-FEB-2022, entry version 61.
DE   RecName: Full=Tegument protein UL51 homolog;
GN   Name=U44;
OS   Human herpesvirus 7 (strain JI) (HHV-7) (Human T lymphotropic virus).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Betaherpesvirinae; Roseolovirus.
OX   NCBI_TaxID=57278;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=8709220; DOI=10.1128/jvi.70.9.5975-5989.1996;
RA   Nicholas J.;
RT   "Determination and analysis of the complete nucleotide sequence of human
RT   herpesvirus.";
RL   J. Virol. 70:5975-5989(1996).
CC   -!- FUNCTION: Plays several roles during the time course of infection,
CC       including egress of virus particles from the perinuclear space and
CC       secondary envelopment of cytoplasmic capsids that bud into specific
CC       trans-Golgi network (TGN)-derived membranes.
CC       {ECO:0000250|UniProtKB:P10235}.
CC   -!- SUBUNIT: Oligomerizes. Interacts with U75; this interaction mediates
CC       U75 incorporation to virions. {ECO:0000250|UniProtKB:P10235,
CC       ECO:0000250|UniProtKB:P16823}.
CC   -!- SUBCELLULAR LOCATION: Virion tegument {ECO:0000250|UniProtKB:P10235}.
CC       Host cytoplasm {ECO:0000250|UniProtKB:P10235}. Host Golgi apparatus
CC       {ECO:0000250|UniProtKB:P10235}.
CC   -!- PTM: Phosphorylated. {ECO:0000250|UniProtKB:P10235}.
CC   -!- PTM: Palmitoylation is necessary for Golgi localization.
CC       {ECO:0000250|UniProtKB:P10235}.
CC   -!- SIMILARITY: Belongs to the herpesviridae UL51 family. {ECO:0000305}.
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DR   EMBL; U43400; AAC54706.1; -; Genomic_DNA.
DR   PIR; T41946; T41946.
DR   RefSeq; YP_073784.1; NC_001716.2.
DR   GeneID; 3289502; -.
DR   KEGG; vg:3289502; -.
DR   Proteomes; UP000009246; Genome.
DR   GO; GO:0044177; C:host cell Golgi apparatus; IEA:UniProtKB-SubCell.
DR   GO; GO:0019033; C:viral tegument; IEA:UniProtKB-SubCell.
DR   InterPro; IPR007619; Herpes_U44.
DR   Pfam; PF04533; Herpes_U44; 1.
PE   3: Inferred from homology;
KW   Host cytoplasm; Host Golgi apparatus; Lipoprotein; Palmitate;
KW   Phosphoprotein; Reference proteome; Virion; Virion tegument.
FT   CHAIN           1..203
FT                   /note="Tegument protein UL51 homolog"
FT                   /id="PRO_0000116211"
FT   LIPID           4
FT                   /note="S-palmitoyl cysteine; by host"
FT                   /evidence="ECO:0000250|UniProtKB:P10235"
SQ   SEQUENCE   203 AA;  23527 MW;  DF862194146BE567 CRC64;
     MGNCFVKKIS SDIFNSNYQM LYSELSEQED LLDFLETKYT DFGILKTDIL NYERDSETFK
     TLLQVLPIYK KTKLRYNLIE RCLNNCPPHV KDALIIEIMK AKKILETLDV VFMKIMIGEF
     TICSDNVNQL LNKFSIDQTT LCDMEKINTL IDLDEENSKR LLTEIDPLLH QETGLYQALP
     NAVTDPPSEQ RAATKKCYEG FTK