ID   TEG7_HHV8P              Reviewed;         227 AA.
AC   F5H9W9;
DT   16-OCT-2013, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 1.
DT   03-AUG-2022, entry version 30.
DE   RecName: Full=Tegument protein ORF55;
GN   Name=ORF55;
OS   Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's
OS   sarcoma-associated herpesvirus).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Gammaherpesvirinae; Rhadinovirus.
OX   NCBI_TaxID=868565;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=10400794; DOI=10.1128/jvi.73.8.6953-6963.1999;
RA   Glenn M., Rainbow L., Aurade F., Davison A., Schulz T.F.;
RT   "Identification of a spliced gene from Kaposi's sarcoma-associated
RT   herpesvirus encoding a protein with similarities to latent membrane
RT   proteins 1 and 2A of Epstein-Barr virus.";
RL   J. Virol. 73:6953-6963(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16760382; DOI=10.1099/vir.0.81919-0;
RA   Rezaee S.A.R., Cunningham C., Davison A.J., Blackbourn D.J.;
RT   "Kaposi's sarcoma-associated herpesvirus immune modulation: an overview.";
RL   J. Gen. Virol. 87:1781-1804(2006).
RN   [3]
RP   FUNCTION, AND INTERACTION WITH VBCL2.
RX   PubMed=29167347; DOI=10.1128/jvi.00914-17;
RA   Liang Q., Wei D., Chung B., Brulois K.F., Guo C., Dong S., Gao S.J.,
RA   Feng P., Liang C., Jung J.U.;
RT   "Novel Role of vBcl2 in the Virion Assembly of Kaposi's Sarcoma-Associated
RT   Herpesvirus.";
RL   J. Virol. 92:0-0(2018).
CC   -!- FUNCTION: Plays several roles during the time course of infection,
CC       including egress of virus particles from the perinuclear space and
CC       secondary envelopment of cytoplasmic capsids that bud into specific
CC       trans-Golgi network (TGN)-derived membranes.
CC       {ECO:0000250|UniProtKB:P10235, ECO:0000269|PubMed:29167347}.
CC   -!- SUBUNIT: Oligomerizes. Interacts with ORF42; this interaction mediates
CC       ORF42 incorporation to virions. Interacts with vBCL2 (PubMed:29167347).
CC       {ECO:0000250|UniProtKB:P10235, ECO:0000250|UniProtKB:P16823,
CC       ECO:0000269|PubMed:29167347}.
CC   -!- SUBCELLULAR LOCATION: Virion tegument {ECO:0000250|UniProtKB:P10235}.
CC       Host cytoplasm {ECO:0000250|UniProtKB:P10235}. Host Golgi apparatus
CC       {ECO:0000250|UniProtKB:P10235}.
CC   -!- PTM: Phosphorylated. {ECO:0000250|UniProtKB:P10235}.
CC   -!- PTM: Palmitoylation is necessary for Golgi localization.
CC       {ECO:0000250|UniProtKB:P10235}.
CC   -!- SIMILARITY: Belongs to the herpesviridae UL51 family. {ECO:0000305}.
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DR   EMBL; AF148805; ABD28906.1; -; Genomic_DNA.
DR   RefSeq; YP_001129408.1; NC_009333.1.
DR   SMR; F5H9W9; -.
DR   BioGRID; 1776935; 1.
DR   DNASU; 4961432; -.
DR   GeneID; 4961432; -.
DR   KEGG; vg:4961432; -.
DR   Proteomes; UP000000942; Genome.
DR   GO; GO:0044177; C:host cell Golgi apparatus; IEA:UniProtKB-SubCell.
DR   GO; GO:0019033; C:viral tegument; IEA:UniProtKB-SubCell.
DR   InterPro; IPR007619; Herpes_U44.
DR   Pfam; PF04533; Herpes_U44; 1.
PE   1: Evidence at protein level;
KW   Host cytoplasm; Host Golgi apparatus; Lipoprotein; Palmitate;
KW   Phosphoprotein; Reference proteome; Virion; Virion tegument.
FT   CHAIN           1..227
FT                   /note="Tegument protein ORF55"
FT                   /id="PRO_0000423807"
FT   REGION          183..227
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        200..227
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   LIPID           11
FT                   /note="S-palmitoyl cysteine; by host"
FT                   /evidence="ECO:0000250|UniProtKB:P10235"
SQ   SEQUENCE   227 AA;  24609 MW;  A645A46895C691AA CRC64;
     MSSPWYTWTC CGINLFGRGN HAYKRLGDPL EGCPERWRQE IDLGLPPGVC LGDVVQSNLG
     TTALHQTYLL AVQSNKITDY LKRFDVAKIP AGCQETVKTQ VKKLQSIQNV VWNTMLALAV
     GEITVDDSAL QSLLNKRAGE CVSLMEMEKL ATAMASDDSV IWASEISHSL SEPTSVLPLT
     PAVTRQPEAT LPKPPTEDPS VSAMHSSIPP RPSSTLEETT ESAIGST