ID   TEG7_VZVD               Reviewed;         259 AA.
AC   P09271;
DT   01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1989, sequence version 1.
DT   02-JUN-2021, entry version 52.
DE   RecName: Full=Tegument protein UL51 homolog;
DE   AltName: Full=ORF7 protein;
GN   ORFNames=ORF7;
OS   Varicella-zoster virus (strain Dumas) (HHV-3) (Human herpesvirus 3).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Alphaherpesvirinae; Varicellovirus.
OX   NCBI_TaxID=10338;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=3018124; DOI=10.1099/0022-1317-67-9-1759;
RA   Davison A.J., Scott J.E.;
RT   "The complete DNA sequence of varicella-zoster virus.";
RL   J. Gen. Virol. 67:1759-1816(1986).
CC   -!- FUNCTION: Plays several roles during the time course of infection,
CC       including egress of virus particles from the perinuclear space and
CC       secondary envelopment of cytoplasmic capsids that bud into specific
CC       trans-Golgi network (TGN)-derived membranes.
CC       {ECO:0000250|UniProtKB:P10235}.
CC   -!- SUBUNIT: Oligomerizes. Interacts with ORF53; this interaction mediates
CC       ORF53 incorporation to virions. {ECO:0000250|UniProtKB:P10235,
CC       ECO:0000250|UniProtKB:P16823}.
CC   -!- SUBCELLULAR LOCATION: Virion tegument {ECO:0000250|UniProtKB:P10235}.
CC       Host cytoplasm {ECO:0000250|UniProtKB:P10235}. Host Golgi apparatus
CC       {ECO:0000250|UniProtKB:P10235}.
CC   -!- PTM: Phosphorylated. {ECO:0000250|UniProtKB:P10235}.
CC   -!- PTM: Palmitoylation is necessary for Golgi localization.
CC       {ECO:0000250|UniProtKB:P10235}.
CC   -!- SIMILARITY: Belongs to the herpesviridae UL51 family. {ECO:0000305}.
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DR   EMBL; X04370; CAA27890.1; -; Genomic_DNA.
DR   PIR; G27212; WZBE7.
DR   SMR; P09271; -.
DR   PRIDE; P09271; -.
DR   Proteomes; UP000002602; Genome.
DR   GO; GO:0044177; C:host cell Golgi apparatus; IEA:UniProtKB-SubCell.
DR   GO; GO:0019033; C:viral tegument; IEA:UniProtKB-SubCell.
DR   InterPro; IPR007625; Herpes_UL51.
DR   Pfam; PF04540; Herpes_UL51; 1.
PE   3: Inferred from homology;
KW   Host cytoplasm; Host Golgi apparatus; Lipoprotein; Palmitate;
KW   Phosphoprotein; Reference proteome; Virion; Virion tegument.
FT   CHAIN           1..259
FT                   /note="Tegument protein UL51 homolog"
FT                   /id="PRO_0000116102"
FT   LIPID           9
FT                   /note="S-palmitoyl cysteine; by host"
FT                   /evidence="ECO:0000250|UniProtKB:P10235"
SQ   SEQUENCE   259 AA;  28246 MW;  B35A744D0217D285 CRC64;
     MQTVCASLCG YARIPTEEPS YEEVRVNTHP QGAALLRLQE ALTAVNGLLP APLTLEDVVA
     SADNTRRLVR AQALARTYAA CSRNIECLKQ HHFTEDNPGL NAVVRSHMEN SKRLADMCLA
     AITHLYLSVG AVDVTTDDIV DQTLRMTAES EVVMSDVVLL EKTLGVVAKP QASFDVSHNH
     ELSIAKGENV GLKTSPIKSE ATQLSEIKPP LIEVSDNNTS NLTKKTYPTE TLQPVLTPKQ
     TQDVQRTTPA IKKSHVMLV