ID   TEKT1_BOVIN             Reviewed;         418 AA.
AC   Q32KZ9;
DT   28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT   06-DEC-2005, sequence version 1.
DT   03-AUG-2022, entry version 81.
DE   RecName: Full=Tektin-1;
GN   Name=TEKT1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Liver;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0007744|PDB:7RRO}
RP   STRUCTURE BY ELECTRON MICROSCOPY (3.40 ANGSTROMS), FUNCTION, SUBCELLULAR
RP   LOCATION, AND TISSUE SPECIFICITY.
RX   PubMed=34715025; DOI=10.1016/j.cell.2021.10.007;
RA   Gui M., Farley H., Anujan P., Anderson J.R., Maxwell D.W., Whitchurch J.B.,
RA   Botsch J.J., Qiu T., Meleppattu S., Singh S.K., Zhang Q., Thompson J.,
RA   Lucas J.S., Bingle C.D., Norris D.P., Roy S., Brown A.;
RT   "De novo identification of mammalian ciliary motility proteins using cryo-
RT   EM.";
RL   Cell 184:5791-5806.e19(2021).
CC   -!- FUNCTION: Microtubule inner protein (MIP) part of the dynein-decorated
CC       doublet microtubules (DMTs) in cilia and flagellar axoneme
CC       (PubMed:34715025). Forms filamentous polymers in the walls of ciliary
CC       and flagellar microtubules (PubMed:34715025).
CC       {ECO:0000269|PubMed:34715025}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme
CC       {ECO:0000269|PubMed:34715025}. Cytoplasm, cytoskeleton, flagellum
CC       axoneme {ECO:0000305|PubMed:34715025}.
CC   -!- TISSUE SPECIFICITY: Expressed in trachea multiciliated cells.
CC       {ECO:0000269|PubMed:34715025}.
CC   -!- SIMILARITY: Belongs to the tektin family. {ECO:0000305}.
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DR   EMBL; BC109833; AAI09834.1; -; mRNA.
DR   RefSeq; NP_001069251.1; NM_001075783.2.
DR   PDB; 7RRO; EM; 3.40 A; A0/A1/A2/A3/A4=1-418.
DR   PDBsum; 7RRO; -.
DR   AlphaFoldDB; Q32KZ9; -.
DR   SMR; Q32KZ9; -.
DR   STRING; 9913.ENSBTAP00000009779; -.
DR   PaxDb; Q32KZ9; -.
DR   PRIDE; Q32KZ9; -.
DR   Ensembl; ENSBTAT00000009779; ENSBTAP00000009779; ENSBTAG00000007437.
DR   GeneID; 519068; -.
DR   KEGG; bta:519068; -.
DR   CTD; 83659; -.
DR   VEuPathDB; HostDB:ENSBTAG00000007437; -.
DR   VGNC; VGNC:35736; TEKT1.
DR   eggNOG; KOG2685; Eukaryota.
DR   GeneTree; ENSGT00950000182894; -.
DR   HOGENOM; CLU_033588_2_2_1; -.
DR   InParanoid; Q32KZ9; -.
DR   OMA; EPLHITQ; -.
DR   OrthoDB; 581072at2759; -.
DR   TreeFam; TF320754; -.
DR   Proteomes; UP000009136; Chromosome 19.
DR   Bgee; ENSBTAG00000007437; Expressed in oviduct epithelium and 59 other tissues.
DR   GO; GO:0005879; C:axonemal microtubule; IDA:UniProtKB.
DR   GO; GO:0015630; C:microtubule cytoskeleton; IBA:GO_Central.
DR   GO; GO:0031514; C:motile cilium; IEA:UniProtKB-KW.
DR   GO; GO:0060271; P:cilium assembly; IBA:GO_Central.
DR   GO; GO:0060294; P:cilium movement involved in cell motility; IBA:GO_Central.
DR   InterPro; IPR000435; Tektin.
DR   PANTHER; PTHR19960; PTHR19960; 1.
DR   PRINTS; PR00511; TEKTIN.
PE   1: Evidence at protein level;
KW   3D-structure; Cell projection; Cilium; Coiled coil; Cytoplasm;
KW   Cytoskeleton; Flagellum; Microtubule; Reference proteome.
FT   CHAIN           1..418
FT                   /note="Tektin-1"
FT                   /id="PRO_0000261166"
FT   REGION          399..418
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          21..84
FT                   /evidence="ECO:0000255"
FT   COILED          268..308
FT                   /evidence="ECO:0000255"
FT   COILED          336..383
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   418 AA;  48719 MW;  7A309E4545FC7218 CRC64;
     MAKLLQQPPK FLRAEWQIAN KNQYHRAEAQ RSRSERLVAE SQRLVDEIEK TTRKSQSDVN
     KKLEQRLEEV RFWKKELDDK LEQLVYATED LLLYQTRLQK ALESFKEPLH ITEKCLEYRE
     KRVGIDLVHD EVEQELIKEH EIIRGVMTLL TRTLEETCEQ IRLNRSAKYN LEKDLRDKFT
     AITIDDICFS LNNNSPNIKY SENVVRVEPN SVSLEDWLDF SNTNVEKADK QRNNSLTLKA
     LVDRILFQTA SDLRRQCDVV DTAFKNGLKE TKDARDKLAL HLDKVMEEIA SQEKNIVVLE
     KAILDQEGPA KVAHTRLETR THRPNVELCR DVAQYRLIKE VDEITHNVAR LKETLAQAHV
     ELKGLNRRQL ALQEEIQIKE NTIYIDEVLC VPMRKSIPPR DGDDHGEWAG GSHPEAVC