TEKT1_HUMAN
ID TEKT1_HUMAN Reviewed; 418 AA.
AC Q969V4; D3DTM7;
DT 08-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 151.
DE RecName: Full=Tektin-1;
GN Name=TEKT1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC TISSUE=Fetal brain;
RX PubMed=11606253; DOI=10.1016/s1357-2725(01)00089-9;
RA Xu M., Zhou Z., Cheng C., Zhao W., Tang R., Huang Y., Wang W., Xu J.,
RA Zeng L., Xie Y., Mao Y.;
RT "Cloning and characterization of a novel human TEKTIN1 gene.";
RL Int. J. Biochem. Cell Biol. 33:1172-1182(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Microtubule inner protein (MIP) part of the dynein-decorated
CC doublet microtubules (DMTs) in cilia and flagellar axoneme. Forms
CC filamentous polymers in the walls of ciliary and flagellar
CC microtubules. {ECO:0000250|UniProtKB:Q32KZ9}.
CC -!- INTERACTION:
CC Q969V4; Q13895: BYSL; NbExp=6; IntAct=EBI-10180409, EBI-358049;
CC Q969V4; Q96LT6: C1orf74; NbExp=3; IntAct=EBI-10180409, EBI-12049899;
CC Q969V4; Q8TD31-3: CCHCR1; NbExp=6; IntAct=EBI-10180409, EBI-10175300;
CC Q969V4; Q8IYR0: CFAP206; NbExp=3; IntAct=EBI-10180409, EBI-749051;
CC Q969V4; O14647: CHD2; NbExp=3; IntAct=EBI-10180409, EBI-1210503;
CC Q969V4; Q5JVL4: EFHC1; NbExp=3; IntAct=EBI-10180409, EBI-743105;
CC Q969V4; O14964: HGS; NbExp=6; IntAct=EBI-10180409, EBI-740220;
CC Q969V4; P55795: HNRNPH2; NbExp=8; IntAct=EBI-10180409, EBI-352823;
CC Q969V4; Q2WGJ6: KLHL38; NbExp=3; IntAct=EBI-10180409, EBI-6426443;
CC Q969V4; O95678: KRT75; NbExp=3; IntAct=EBI-10180409, EBI-2949715;
CC Q969V4; Q969R5: L3MBTL2; NbExp=3; IntAct=EBI-10180409, EBI-739909;
CC Q969V4; Q8TCE9: LGALS14; NbExp=3; IntAct=EBI-10180409, EBI-10274069;
CC Q969V4; Q9UJV3-2: MID2; NbExp=3; IntAct=EBI-10180409, EBI-10172526;
CC Q969V4; Q96FA6: NCAPD3; NbExp=3; IntAct=EBI-10180409, EBI-10285636;
CC Q969V4; Q9Y5B8: NME7; NbExp=5; IntAct=EBI-10180409, EBI-744782;
CC Q969V4; Q96HA8: NTAQ1; NbExp=3; IntAct=EBI-10180409, EBI-741158;
CC Q969V4; Q7Z3B4: NUP54; NbExp=3; IntAct=EBI-10180409, EBI-741048;
CC Q969V4; P54619: PRKAG1; NbExp=6; IntAct=EBI-10180409, EBI-1181439;
CC Q969V4; Q06455-2: RUNX1T1; NbExp=3; IntAct=EBI-10180409, EBI-11984663;
CC Q969V4; O00560: SDCBP; NbExp=3; IntAct=EBI-10180409, EBI-727004;
CC Q969V4; Q8WW24: TEKT4; NbExp=3; IntAct=EBI-10180409, EBI-750487;
CC Q969V4; Q3SY00: TSGA10IP; NbExp=3; IntAct=EBI-10180409, EBI-10241197;
CC Q969V4; P57075-2: UBASH3A; NbExp=3; IntAct=EBI-10180409, EBI-7353612;
CC Q969V4; Q9H3U1: UNC45A; NbExp=3; IntAct=EBI-10180409, EBI-1048763;
CC Q969V4; Q8N6Y0: USHBP1; NbExp=3; IntAct=EBI-10180409, EBI-739895;
CC Q969V4; P18206: VCL; NbExp=3; IntAct=EBI-10180409, EBI-716775;
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme
CC {ECO:0000250|UniProtKB:Q32KZ9}. Cytoplasm, cytoskeleton, flagellum
CC axoneme {ECO:0000250|UniProtKB:Q32KZ9}.
CC -!- TISSUE SPECIFICITY: Predominantly expressed in testis.
CC {ECO:0000269|PubMed:11606253}.
CC -!- SIMILARITY: Belongs to the tektin family. {ECO:0000305}.
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DR EMBL; AF357879; AAL27695.1; -; mRNA.
DR EMBL; CH471108; EAW90284.1; -; Genomic_DNA.
DR EMBL; CH471108; EAW90285.1; -; Genomic_DNA.
DR EMBL; BC014599; AAH14599.1; -; mRNA.
DR CCDS; CCDS11083.1; -.
DR RefSeq; NP_444515.1; NM_053285.1.
DR AlphaFoldDB; Q969V4; -.
DR SMR; Q969V4; -.
DR BioGRID; 123716; 29.
DR IntAct; Q969V4; 27.
DR STRING; 9606.ENSP00000341346; -.
DR iPTMnet; Q969V4; -.
DR PhosphoSitePlus; Q969V4; -.
DR SwissPalm; Q969V4; -.
DR BioMuta; TEKT1; -.
DR DMDM; 25009461; -.
DR EPD; Q969V4; -.
DR jPOST; Q969V4; -.
DR MassIVE; Q969V4; -.
DR PaxDb; Q969V4; -.
DR PeptideAtlas; Q969V4; -.
DR PRIDE; Q969V4; -.
DR ProteomicsDB; 75852; -.
DR Antibodypedia; 23852; 143 antibodies from 25 providers.
DR DNASU; 83659; -.
DR Ensembl; ENST00000338694.7; ENSP00000341346.2; ENSG00000167858.13.
DR GeneID; 83659; -.
DR KEGG; hsa:83659; -.
DR MANE-Select; ENST00000338694.7; ENSP00000341346.2; NM_053285.2; NP_444515.1.
DR UCSC; uc002gdt.4; human.
DR CTD; 83659; -.
DR DisGeNET; 83659; -.
DR GeneCards; TEKT1; -.
DR HGNC; HGNC:15534; TEKT1.
DR HPA; ENSG00000167858; Tissue enriched (fallopian).
DR MIM; 609002; gene.
DR neXtProt; NX_Q969V4; -.
DR OpenTargets; ENSG00000167858; -.
DR PharmGKB; PA37976; -.
DR VEuPathDB; HostDB:ENSG00000167858; -.
DR eggNOG; KOG2685; Eukaryota.
DR GeneTree; ENSGT00950000182894; -.
DR HOGENOM; CLU_033588_2_2_1; -.
DR InParanoid; Q969V4; -.
DR OMA; EPLHITQ; -.
DR OrthoDB; 581072at2759; -.
DR PhylomeDB; Q969V4; -.
DR TreeFam; TF320754; -.
DR PathwayCommons; Q969V4; -.
DR SignaLink; Q969V4; -.
DR SIGNOR; Q969V4; -.
DR BioGRID-ORCS; 83659; 4 hits in 1066 CRISPR screens.
DR ChiTaRS; TEKT1; human.
DR GeneWiki; TEKT1; -.
DR GenomeRNAi; 83659; -.
DR Pharos; Q969V4; Tbio.
DR PRO; PR:Q969V4; -.
DR Proteomes; UP000005640; Chromosome 17.
DR RNAct; Q969V4; protein.
DR Bgee; ENSG00000167858; Expressed in bronchial epithelial cell and 116 other tissues.
DR ExpressionAtlas; Q969V4; baseline and differential.
DR Genevisible; Q969V4; HS.
DR GO; GO:0005879; C:axonemal microtubule; ISS:UniProtKB.
DR GO; GO:0015630; C:microtubule cytoskeleton; IBA:GO_Central.
DR GO; GO:0031514; C:motile cilium; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; HDA:UniProtKB.
DR GO; GO:0060271; P:cilium assembly; IBA:GO_Central.
DR GO; GO:0060294; P:cilium movement involved in cell motility; IBA:GO_Central.
DR InterPro; IPR000435; Tektin.
DR PANTHER; PTHR19960; PTHR19960; 1.
DR PRINTS; PR00511; TEKTIN.
PE 1: Evidence at protein level;
KW Cell projection; Cilium; Coiled coil; Cytoplasm; Cytoskeleton; Flagellum;
KW Microtubule; Reference proteome.
FT CHAIN 1..418
FT /note="Tektin-1"
FT /id="PRO_0000184562"
FT COILED 21..107
FT /evidence="ECO:0000255"
FT COILED 134..177
FT /evidence="ECO:0000255"
FT COILED 266..308
FT /evidence="ECO:0000255"
FT COILED 333..384
FT /evidence="ECO:0000255"
FT VARIANT 146
FT /note="I -> V (in dbSNP:rs34431552)"
FT /id="VAR_034548"
FT VARIANT 254
FT /note="R -> C (in dbSNP:rs3744395)"
FT /id="VAR_022150"
FT VARIANT 332
FT /note="V -> I (in dbSNP:rs2271233)"
FT /id="VAR_022151"
SQ SEQUENCE 418 AA; 48283 MW; 724A9172C627BA52 CRC64;
MAKLLQPPPK FLPSEWHIAN KNQYHRADAQ RSRSERLVAE SQRLVDEIEK TTRKSQSDVN
KKLEQRLEEV QFWKKELDDK LEQLVNVTDD LLIYKIRLEK ALETLKEPLH ITETCLAYRE
KRIGIDLVHD TVEHELIKEA EIIQGIMALL TRTLEEASEQ IRMNRSAKYN LEKDLKDKFV
ALTIDDICFS LNNNSPNIRY SENAVRIEPN SVSLEDWLDF SSTNVEKADK QRNNSLMLKA
LVDRILSQTA NDLRKQCDVV DTAFKNGLKD TKDARDKLAD HLAKVMEEIA SQEKNITALE
KAILDQEGPA KVAHTRLETR THRPNVELCR DVAQYRLMKE VQEITHNVAR LKETLAQAQA
ELKGLHRRQL ALQEEIQVKE NTIYIDEVLC MQMRKSIPLR DGEDHGVWAG GLRPDAVC
